<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31158

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDSVDILLVPFPREYSYGYNYDYFLENIVSRIVARYGAFRKLKISSFLDMKDDLDDNDDLKQKQDFNFSDIFDLKCDVQQIKEKLINMISNAQNECSLVLDFVSLLVSSVKPVLGNSSMSTFLKERIPVGSFGCERVRGDIFSEDFVVSKGWKLQALSKVTSDLLDASVKIDKEITLEAKFWDQVNILRQNGWNLMHSRIGRDKNFVINYGIMDVSRIFGRGFAILKRSIDGDIKFDGVDMFETFKITRLRFLENNVIKGEAVWDNSSFSEFFDKNTQILSQRRDSFFEEELLEEIIREINFFDDLNAVILDNGISVEIMESKRLLLLDIVDASTKANEFNKEYDVLCEIVLLALHLFFSYYECQKLKWTDNFPFLSKIQNKKQTRILFPIVSQLSHYFILDEVSKELKSCINVILAEGWTVDYKIKKYVDMDFGISEDSIIQSIVNGPRSVIEMYLPGSSQIVIDIRTVDYKTSFEVDFHNIRINGLMTSKTVCGSILEVLECIIWSINKDFVNVLQEAVTPNWEIKNGELVNINNTMKIKIEVFIQRNEDGIWKIFLYKNGTFVNIQDKISDVLNKIL
Length580
PositionHead
OrganismPneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent) (Pneumocystis carinii f. sp. muris)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Pneumocystidomycetes> Pneumocystidaceae> Pneumocystis.
Aromaticity0.11
Grand average of hydropathy-0.075
Instability index36.73
Isoelectric point4.96
Molecular weight67226.49
Publications
PubMed=26899007

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31158
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.57|      18|      46|     421|     448|       1
---------------------------------------------------------------------------
  421-  448 (22.10/30.87)	TVDYKIKkyVDMDFgisedsiiQSI.VNG
  469-  487 (30.47/15.24)	TVDYKTS..FEVDF........HNIrING
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.69|      25|      28|     150|     177|       2
---------------------------------------------------------------------------
  150-  174 (39.66/30.24)	KGW.KLQALSKVTSDLLDASVKIDKE
  180-  205 (42.03/23.80)	KFWdQVNILRQNGWNLMHSRIGRDKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.34|      67|     225|      24|     111|       3
---------------------------------------------------------------------------
   24-  111 (90.10/98.42)	FLEN..IVSRIVARYGAFrklkiSSFLDMKDDLddnddLKQKQD..............FNFSDifDLKCDVqqikekLINMISNAQNECS..LVLDFVSllvSSVK
  252-  336 (98.24/59.53)	FLENnvIKGEAVWDNSSF.....SEFFDKNTQI.....LSQRRDsffeeelleeiireINFFD..DLNAVI......LDNGISVEIMESKrlLLLDIVD...ASTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.15|      15|      49|     506|     521|       4
---------------------------------------------------------------------------
  506-  521 (23.69/17.77)	IWSI....NKDFVNVlQEAV
  554-  572 (24.46/13.46)	IWKIflykNGTFVNI.QDKI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31158 with Med17 domain of Kingdom Fungi
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