Description | Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MIDLSVIAWRMPEWITAYGRLCTDNVLDYFSQSPFYDRHSNNEVLKMQTQFNTLGDFHGHLKKMRGIEFVISAEKDPDIWVIYKQHRSSENDASVLAAYFVANESIYMAPSIHSVISSRMLNIILSLRQALASVHNLHHFSSITEYSYSAPEVPSKEMPIHNIKANQHMRKALNDAIREKLYDMTQSKDETKQELQENSSDDHFKAKLDPTSTIVKKKKKTKKSESPASPKL |
Length | 232 |
Position | Head |
Organism | Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent) (Pneumocystis carinii f. sp. muris) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Taphrinomycotina> Pneumocystidomycetes> Pneumocystidaceae> Pneumocystis. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.567 |
Instability index | 58.32 |
Isoelectric point | 8.46 |
Molecular weight | 26690.07 |
Publications | PubMed=26899007 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143 |
GO - Cellular Component | mediator complex GO:0016592 IEA:EnsemblFungi |
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:EnsemblFungi |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP31153 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 133.42| 39| 107| 5| 44| 1 --------------------------------------------------------------------------- 5- 44 (70.79/53.32) SVIAWRMPEWITAYGR.LCTDNVLDYFSQSPFYDrHSNNEV 114- 153 (62.63/42.10) SVISSRMLNIILSLRQaLASVHNLHHFSSITEYS.YSAPEV --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ELQENSSDDHFKAKLDPTSTIVKKKKKTKKSESPASPKL 2) IREKLY 3) IWVIYK | 194 177 79 | 232 182 84 |
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