<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31149

Description Mediator of RNA polymerase II transcription subunit 16 (Fragment)
SequenceIEDCLPPLGSSPSKRFSPSKRKQYYINQAIRNSDLIPKAKGRKSLQRLENTRYLMTLLERDECGNDDGELTHSAAPSIFTEACNNETYMEIWNDFMNRSGEEQERVLLYLEEEAKKKHKRKLPVKAEDTWKEHPAYTPKECFQRISRRLRTTLRRGRIPMVRPCHVIGLVTVQGTLECLEEELLAFFSVTPHSVYTAMMDNSFERLLLHALCQYMDLVSANLTHMIHILDTEHPWDVYSINSGHIEIITCLEWDQSGSRLLSADADGHIKCWSMTDHLANSWENTVGSMVEGDPIVALSWLHNGVKLALHVEKSGASNFGEKFSRVKFSPSLTLFGGKPMEGWIAVTISGLVTVSLLKPNGQVLTSTESLCRLRCRVALADIAFTGGGNIVVATSDGSSTSPVQFYKVCVSVVNEKCKIDTEILPSLFMRCTTDPARKDKYPAITHLKFLARDMSEQVLLCASNQNSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPMILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVANDTKFFPGLGLALAFHDGSVHIVHRLSLQTMAVFYGSSSQRPVDEQAIKRQRAAGPLVHFKAMQLSWTSLALVGIDNHGKLSMLRISPSMGHVLDMNMSLRHLLFLLEYCMVTGYDWWDILLHVQPNMVQNLVEKLHEEYMRQNAALQQVLSTRIVAMKASLCKLSSNTVARVCDYHAKLFLIAISCTLKSLLRPHFLNTPDKSPGDRLTEICSKITDIDIDKVMINLKTEEFVLEMTTLQSLQQLIQWVGDFVLYLLASLPNQGSPVRPGHSFLRDGASLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWLCCRDETHPSEPDDTLIDECCLLPSQLLIPNVDWLPINNGIISKLQNKQLIRLQFGKAPGLIGHTVSSQFDVFVRAPGQPKIDHLRRLHLGAYPTEECKSCTRCGCVTMLKSPNKTTAVKQWEQRWIKNCLCGGLWRRMPLSYS
Length1005
PositionTail
OrganismChelonia mydas (Green sea-turtle) (Chelonia agassizi)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Testudines> Cryptodira> Durocryptodira> Americhelydia> Chelonioidea> Cheloniidae> Chelonia.
Aromaticity0.07
Grand average of hydropathy-0.116
Instability index49.68
Isoelectric point8.40
Molecular weight113217.16
Publications
PubMed=23624526

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31149
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.43|      24|     190|     446|     489|       1
---------------------------------------------------------------------------
  251-  274 (46.23/17.11)	LEWDQSGSRLLSADADGH..IKCWSM
  450-  475 (39.20/39.31)	LARDMSEQVLLCASNQNSsiVECWSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.95|      32|     189|     140|     172|       2
---------------------------------------------------------------------------
  140-  172 (55.63/44.46)	ECFQRISRRLRTTLRRGRiPMVR..PCHVIGLVTV
  321-  354 (51.32/35.63)	EKFSRVKFSPSLTLFGGK.PMEGwiAVTISGLVTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.34|      24|      33|     802|     833|       6
---------------------------------------------------------------------------
  802-  829 (34.70/37.64)	PVRPGHSFLRDGASLgMLRelmVVIRIW
  838-  861 (42.63/21.09)	PVYTATSDTQDSMSL.LFR...LLTKLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.98|      10|      17|     916|     925|       9
---------------------------------------------------------------------------
  916-  925 (20.38/11.74)	FGKAPGL..IGH
  934-  945 (15.59/ 7.34)	FVRAPGQpkIDH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.55|      37|     323|      43|      83|      12
---------------------------------------------------------------------------
   43-   83 (57.23/51.44)	KSLQRLEnTRYLMTLLERDECGN.....DDGeltHSAAPSIFTEAC
  368-  409 (61.32/41.58)	ESLCRLR.CRVALADIAFTGGGNivvatSDG...SSTSPVQFYKVC
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31149 with Med16 domain of Kingdom Metazoa
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