<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31098
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MTTTTQEGTIPNRWHDLRLPLEPYLLTTSSRLATSIKELTPAGEAVYEPEEDAAQRLTKDLRRLWERGDYAELTEDALRREMEQEGGKDDQIQEDQEQEDDGEESEEEAIRPEELWKLKQEVLTKLHEAMQQTVTSQTLLALLQQSSGPQPKPSRLGMPAPPPPPIPLDGFPSMTATLTTPNAPVAATQLRRLQLSAGLRNSSLRHACRIFDTGAEDIERSLSREGQYFQRALALREHWRLAPRVERGQRRRAAKDSARDFEVYYGMEGAPLAERARAVAHLNPTSGEGELLFPSRTHRRLRVSLHVLSPSSLAHLAGSSTPDTPHSEPKADLNTQLKEAQREVLDREIFNRIVRESMDLVQLSPVIRERMVSLRPLPELELTFELIDPSEPPDPSDPAEPSHSPAMQLLCSLLPLLHLPRTRPSLLQPILTLLQYNQFTSLLTLTLSHIQQSLASSGLPIQIRKSLVSPTPSVWQSILGTDPHALGGEIRLSLPECGPIFLSVSYPSALVLQSQKQAISITSLAELRQFLAAEILARLGKLLERIARRVLRAHAASLGGGMDVEWTLGPGGKGWCEWTSGAVSFHLTISLSLSASSTSPSSSGEHEPDWGTFDLKGKAVFSKRLGREGMTPATPTPTPTPTPTPILGVGMGTGMGRVERLTKSWPERGVGVEEWFESGMRWVVLDE |
Length | 687 |
Position | Head |
Organism | Dacryopinax primogenitus (strain DJM 731) (Brown rot fungus) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Dacrymycetes>
Dacrymycetales> Dacrymycetaceae> Dacryopinax.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.427 |
Instability index | 58.44 |
Isoelectric point | 5.67 |
Molecular weight | 76073.48 |
Publications | PubMed=22745431
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP31098
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 515.71| 135| 144| 53| 194| 1
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53- 189 (203.00/102.44) .........AAQR..LTKDL..R...RLWERGDYAELTEDALRREMEQEGGKDDQIQEDQ......EQEDDGEESEEEAIRPEELWKLKQEVLTKLHEAMqQTVTSqtLLALLQQSSG......PQPKPSRLGmpAPPPPPIPLDGF.PS.MTATL...TTPNAPVAATQ
192- 329 (148.86/66.62) RLQ....lsAGLR...NSSL..RhacRIFDTG..AEDIERSLSRE.GQYFQRALALREHWrlaprvERGQRRRAAKDSARDFEVYYGMEGAPLAERARA..........VAHLNPTSGegellfPSRTHRRLR........VSLHVLsPS.SLAHLagsSTPDTPHSEP.
330- 458 (163.85/69.81) KADlntqlkEAQRevLDREIfnR...IVRESMDLVQLSPVIRERMVSLRPLPEL...................ELTFELIDPSEPPDPSDPAEPSHSPAM.QLLCS..LLPLLHL.........PRTRPSLL...QPILTLLQYNQF.TSlLTLTL...SHIQQSLASSG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 84.37| 25| 144| 474| 504| 2
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14- 41 (36.22/15.37) WHDLrLPLEPYLLTTSSRLatSIKELTP
475- 499 (48.15/33.15) WQSI.LGTDPHALGGEIRL..SLPECGP
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