<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31098

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTTTTQEGTIPNRWHDLRLPLEPYLLTTSSRLATSIKELTPAGEAVYEPEEDAAQRLTKDLRRLWERGDYAELTEDALRREMEQEGGKDDQIQEDQEQEDDGEESEEEAIRPEELWKLKQEVLTKLHEAMQQTVTSQTLLALLQQSSGPQPKPSRLGMPAPPPPPIPLDGFPSMTATLTTPNAPVAATQLRRLQLSAGLRNSSLRHACRIFDTGAEDIERSLSREGQYFQRALALREHWRLAPRVERGQRRRAAKDSARDFEVYYGMEGAPLAERARAVAHLNPTSGEGELLFPSRTHRRLRVSLHVLSPSSLAHLAGSSTPDTPHSEPKADLNTQLKEAQREVLDREIFNRIVRESMDLVQLSPVIRERMVSLRPLPELELTFELIDPSEPPDPSDPAEPSHSPAMQLLCSLLPLLHLPRTRPSLLQPILTLLQYNQFTSLLTLTLSHIQQSLASSGLPIQIRKSLVSPTPSVWQSILGTDPHALGGEIRLSLPECGPIFLSVSYPSALVLQSQKQAISITSLAELRQFLAAEILARLGKLLERIARRVLRAHAASLGGGMDVEWTLGPGGKGWCEWTSGAVSFHLTISLSLSASSTSPSSSGEHEPDWGTFDLKGKAVFSKRLGREGMTPATPTPTPTPTPTPILGVGMGTGMGRVERLTKSWPERGVGVEEWFESGMRWVVLDE
Length687
PositionHead
OrganismDacryopinax primogenitus (strain DJM 731) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Dacrymycetes> Dacrymycetales> Dacrymycetaceae> Dacryopinax.
Aromaticity0.05
Grand average of hydropathy-0.427
Instability index58.44
Isoelectric point5.67
Molecular weight76073.48
Publications
PubMed=22745431

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31098
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     515.71|     135|     144|      53|     194|       1
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   53-  189 (203.00/102.44)	.........AAQR..LTKDL..R...RLWERGDYAELTEDALRREMEQEGGKDDQIQEDQ......EQEDDGEESEEEAIRPEELWKLKQEVLTKLHEAMqQTVTSqtLLALLQQSSG......PQPKPSRLGmpAPPPPPIPLDGF.PS.MTATL...TTPNAPVAATQ
  192-  329 (148.86/66.62)	RLQ....lsAGLR...NSSL..RhacRIFDTG..AEDIERSLSRE.GQYFQRALALREHWrlaprvERGQRRRAAKDSARDFEVYYGMEGAPLAERARA..........VAHLNPTSGegellfPSRTHRRLR........VSLHVLsPS.SLAHLagsSTPDTPHSEP.
  330-  458 (163.85/69.81)	KADlntqlkEAQRevLDREIfnR...IVRESMDLVQLSPVIRERMVSLRPLPEL...................ELTFELIDPSEPPDPSDPAEPSHSPAM.QLLCS..LLPLLHL.........PRTRPSLL...QPILTLLQYNQF.TSlLTLTL...SHIQQSLASSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.37|      25|     144|     474|     504|       2
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   14-   41 (36.22/15.37)	WHDLrLPLEPYLLTTSSRLatSIKELTP
  475-  499 (48.15/33.15)	WQSI.LGTDPHALGGEIRL..SLPECGP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31098 with Med17 domain of Kingdom Fungi
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