<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31095

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMQSSAHSKSRLPEKSTFTSPQSSSSPANAKTGSTTSTKDAPSSSHLPQQLPIATPLIINNSTPLSLSKIEWPKDAFVKWRVLEWKDGLEIAEKDKEELIEKARRKLVDEWKDGVLDGLVGYTRRGAGINNPELWIFEVGDMRDGDALSQFFVPGLSAAMLVPREEFRRPLWLFFLSVREKALDRLARSREGCRLGDGVVFECSDRSSKDLDNGWLSDYSSLYLMQANIHIWMTSRCFFIQPSLRSSSLLNFPTIEQTQPPSMTAVTLLPYGYPAYFLSRSQTTASPTALDPYFQGLGTSTWRLNERETAWLECWILTPSTVANADSGVSIFWPAYLVVQDLSRDALNLQLLPDSLRAILPEQTIPSTPWNPALILATHLPRCTINGAAYQFSVDEEAGKMMSGDHPGTARPSAGKVASEIELVLADSVTAFDFTRSAVAARDAARTSRPILEQERKDRENYRFEENDTSVKYTPGQTLTMACRRWVLTGDDAVNEEELGEFSTAEASLSDDLDPYLDDTIMDEAEMSTPRIRSIDESGAGTKSSSEEPSAHINAPGIVATPQDTIGSPRSVGSISSMSPMAFPSSSNIKSRTHNITAPLTPDGIDDDSVSAGLKTQQSEGPVVAASSPWQPSASNDSAVLPVPSLFNHVPSLLSAPIVTHPRSDMSGDDGMDGLGLTEDDFAFYDAAPSRQKQLLDEGALDDDIDIFHPPPDGLPSPPDEPIQLDDVDQVQLESQSAFSFEHPASDGTQPVTIESASVEEGQMFETFAPVDGDRTPVAPLSSVIGAKMIFIDPFEPLVDHQSRDSEYTLGKFAMDKYGFPFICDVSPRQSCFFTWDTVDKPLFDPYSNPHVGLIRHRRGTKRSRSMAFGDEKTTDCPAKRIRCSWIDIEDVKRAAEQRRQEELAMDDRSDATLDDETLVVLDEEEEIIPQKEEPASWPPQLLWSLTLMMGVFNIPGLTPALSPPAVQISSPSPLAALTPVSPAAFIQIQDNLKKQEDAANVRCAQVLENPVLLEWILQSRIIRSDEVRWTTLFNLGRLKKAIDGAISAPKQLAIGDCLNKSDLPQTDRPTGSKTGTEPSLVILDRTSPLAIGLDGAVVNVTWPAIRFWEKLALCPVSGQKDVLAFAFYDTSANPANRKDSLLKKWLLSMGEIYAHLGYGQHKLGELDELGIRHGLLSGKLGDLESQLSALSSGIPTDVWHIVIYVFCGPLQLLSLEQALTGCSDALSSRMAIHLLPDSSLTYVSRTCFFRPNPLHLTALSVYNRLLRVVKRTTLRQLYGAQPAAKRVFQYPAVTVARPANPKVGFSLEWPPKNADVLDPVPYLHVAYTHSSEWLFASCIDQLGEAYTQRVWSMKQGDKAASIEVLVARIWSFAWKFARRARKEWQIVVARWGACPVAEVEERSGGHLLVPASSLGILLLLFSWSGYCRFPKRHAGILIRLLLEPDYQTGQERLMYPPHTTFVKRTTRPLPDLPYLEAVGPTSTVVMGSEERAYHRRDPPTRPPVV
Length1505
PositionKinase
OrganismDacryopinax primogenitus (strain DJM 731) (Brown rot fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Dacrymycetes> Dacrymycetales> Dacrymycetaceae> Dacryopinax.
Aromaticity0.08
Grand average of hydropathy-0.278
Instability index59.34
Isoelectric point5.11
Molecular weight166294.24
Publications
PubMed=22745431

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP31095
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     348.97|      96|     220|     289|     413|       1
---------------------------------------------------------------------------
  315-  413 (158.31/145.56)	ILTPSTVAnADSGVSIfwPAYLVVQD.LSR..DALN....L...QLL..PD.SLRAILPEQTI..PSTP..WN.PALILATHLPRCTING...AAYQFSVDEEAGKMMSGDHP..GTARPSA
  968- 1069 (117.42/61.38)	ISSPSPLA.ALTPVSP..AAFIQIQDnLKKqeDAAN....VrcaQVLenPV.LLEWILQSRII..RSDEvrWT.TLFNLG.RLKK.AIDGaisAPKQLAIGDCLNK...SDLP..QTDRP..
 1224- 1300 (73.25/33.26)	................................DALSsrmaI...HLL..PDsSLTYV..SRTCffRPNP..LHlTALSVYNRLLRVVKRT...TLRQLYGAQPAAKRVF.QYPavTVARPAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.58|      20|      24|     750|     769|       2
---------------------------------------------------------------------------
  750-  769 (34.86/18.53)	PVTIESASVEEGQMF.ETFAP
  776-  796 (31.72/16.25)	PVAPLSSVIGAKMIFiDPFEP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.73|      18|      19|       8|      26|       3
---------------------------------------------------------------------------
    8-   26 (27.94/18.10)	KSRlPEKSTFTSPQSSSSP
   30-   47 (31.79/16.54)	KTG.STTSTKDAPSSSHLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.23|      20|      21|     678|     697|       4
---------------------------------------------------------------------------
  678-  697 (34.04/18.18)	EDDFAFYDAAPSRQKQLLDE
  701-  720 (38.19/21.44)	DDDIDIFHPPPDGLPSPPDE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.23|      18|      25|      70|      87|       6
---------------------------------------------------------------------------
   70-   87 (38.32/29.69)	EWPKDAFV.KWR...VLEWKDG
   92-  113 (23.91/15.19)	EKDKEELIeKARrklVDEWKDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.75|      12|      18|     241|     252|       7
---------------------------------------------------------------------------
  241-  252 (21.88/11.61)	PSLRSSSLL..NFP
  260-  273 (17.87/ 8.13)	PSMTAVTLLpyGYP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.07|      17|     305|     200|     217|       8
---------------------------------------------------------------------------
  200-  217 (29.18/20.47)	FECSDRS.SKDLDnGWLSD
  501-  518 (26.89/13.68)	FSTAEASlSDDLD.PYLDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.95|      24|      27|     797|     822|       9
---------------------------------------------------------------------------
  799-  822 (45.51/30.06)	DHQSRDSEY....TLGKFAMDKYGFPFI
  824-  851 (40.45/20.07)	DVSPRQSCFftwdTVDKPLFDPYSNPHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.09|      23|      39|     529|     551|      10
---------------------------------------------------------------------------
  529-  551 (39.15/21.30)	PRIRSIDESGAGT.KS....SSEEPSAH
  555-  582 (29.58/14.31)	PGIVATPQDTIGSpRSvgsiSSMSPMAF
  583-  597 (19.35/ 6.82)	P.......SSSNI.KS....RTHNITA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.36|      25|     305|     629|     661|      12
---------------------------------------------------------------------------
  629-  658 (27.37/27.13)	WQPSASNdSAVLpVPSLFNhVPSLlsAPIV
  937-  961 (48.99/17.38)	WPPQLLW.SLTL.MMGVFN.IPGL..TPAL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31095 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KQLLDEGALDDDIDIFHPPPDGLPSPPDEPIQLDDVD
2) LDPYLDDTIMDEAEMSTPRIRSIDESGAGTKSSSEEPSAHINAPGIVATPQDTIGSPRSVGSISSMSPMAFPSSSNIKSRTHNITAPLTPDGIDDDSVSAGLKTQQSEGPVVAASSPWQPSASNDSAVLP
3) MQSSAHSKSRLPEKSTFTSPQSSSSPANAKTGSTTSTKDAPSSSHLPQQLPI
692
512
1
728
641
52










Molecular Recognition Features






MoRF SequenceStartStop




1) EERAYHRR
2) GLTEDDFAFYDAAP
3) RQKQLL
1489
675
690
1496
688
695