<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP31084

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVGRAAEESFLSLTELVEKAKSPELSDTEKKLSLLKYVVKTQQRMLRLNALAKWCKQVPLINRLQDVGSTLSAHDICFTQAADSLFFMHEGLQQARAPVYDVPSAIEVLLTGSYQRLPKCVDDVGMQCSLDEHQQKPALRKLEVLVRSKLLEITLPKEITEVKVSKGTVTLSVEGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGGPIKLEVTRRHILGDDLERRMSVAENPFTILYAVLHELCVAIVMDTVIRQVRTLLHGRWKDAIRFDLISDTGTAPANQEGEADSVSLKTPGVKLMYWLDSDKNNAGSFVKIEPGSDLQIKCSHSTFVIDPLTGKEAEFSLDQSCIDVEKLLLKAICCNRYTRLLEIQKELLRSDRICRAPSDVILQAFLDEPGSEGSSMVDSKEQKEPEVLRVRAYGSSFFTLGINIRTGKFLLQSSKSVLTPSILVEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLGLEVYEHGFGVNKAPKSLSDGSSILALGFPDCESSHLLLMELEKDFTPLFKLAETQTDGSGKPQFLNDLSNVLRVKKIDIGQIRILEDDLNLITSDVASFVSSFSDAERSLSQASGHRGPGLVEESLAEMSGGQLSFSSIVDEVFGHQKVTSSADGKAPLLTSYQSDSFYSMQGPLESSSFNLLSSPPPGKGSAMKKNSNKELSMVLSPSLTVVSESADLAVTSDGPLLRKDQKSRKRSASDLLRLIPSLQGVEGVTHPNKRSKASASQALSTAVVTSTKAIGCSYGDLIAEANKGNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYVEEMGLRDSFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKSTPWGSGVHIANSSDVDSHIRYDPEGVVLTYQSVEADSIKKLVADIQRLSNARRFSLGMWKLLGIKADEKTEEPGGANPAVKGPAGGKGGGEAVDRWRAFKIEAVGLTSLWFSFGSGIMARFVVEWESGKDECTMHVSPDQHWPHTKFLEDFINGGEVESLLDCIRLTAGPLTALAAATRPARASSATGVTVVPATATSRQSNQTQQTQPSTLAAPNAVGQSASGSALASPSPAPSPLGGSFHGAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTGSQGGATNPNSGSRVNFSPSSVMSRAVMSRVGSVASGSLVAGSGLSVRRPLGSGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKENEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQQQQQNGSSGTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPIPVLREFLKLIAWKKGLSQSQQAGEVAPAQRPRIELCLENHSGADVETSCAAKSNIHFDRPQSTVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYTFGDNPSVTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSAAGDLTQGKLKLVADSVQRTLHLCLQGLSSNNTLQKEFTI
Length1634
PositionTail
OrganismBrassica rapa subsp. pekinensis (Chinese cabbage) (Brassica pekinensis)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Brassiceae> Brassica.
Aromaticity0.07
Grand average of hydropathy-0.121
Instability index45.42
Isoelectric point6.71
Molecular weight177556.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP31084
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     349.18|      86|     265|    1210|    1312|       1
---------------------------------------------------------------------------
 1093- 1160 (89.98/42.87)	............................A...TSRQSNQTQQTQ.PSTL...AAPNAVGQSASGSALA.SPSPAPSPLG.GSF.HGAAGRSGPGIVPsslLPIDVS
 1210- 1307 (126.41/91.19)	PQFRPFImehvaqELNgLEpNltgsQGGA...TNPNSGSRVNFS.PSSVMSRAVMSRVGSVASGSLVAGSGLSVRRPLGSGVP.AHVRGELNTAIIG...LGDDGG
 1477- 1565 (132.79/69.63)	PAQRPRI......ELC.LE.N....HSGAdveTSCAAKSNIHFDrPQSTVDFA.LTVVLDPAHIPHINAAGGAAWLPYCVSVRlRYTFGD.NPSVTF...LGMEGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     327.38|     113|     264|     120|     249|       2
---------------------------------------------------------------------------
  120-  249 (157.42/143.92)	EVLLTGSYQRLPkcvDDVGMQCSLDEhqqkPAlRKLEVLVRSKllEITLPkEITEVKV.SKGTVTLSVE...GEF......KVL...VTLGYRGHLSMWRILHLDLLVGERSGGPIKLEVTRRHILGddLErrmsVAENPFTI
  388-  513 (169.97/107.24)	ELLRSDRICRAP...SDVILQAFLDE....PG.SEGSSMVDSK..EQKEP.EVLRVRAyGSSFFTLGINirtGKFllqsskSVLtpsILVEFEDALNQGSISAVDAFINLRSKSILHFFAAIGKFLG..LE....VYEHGFGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.84|      15|     337|    1036|    1054|       3
---------------------------------------------------------------------------
 1036- 1054 (23.13/27.25)	DQHWPHTKFledFInGGEV
 1361- 1375 (29.71/18.35)	DQEQPALRF...FV.GGYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.40|      14|     270|     317|     335|      11
---------------------------------------------------------------------------
  321-  335 (21.15/21.67)	KNNAGSFVkIEP..GSD
  339-  354 (22.24/ 6.54)	KCSHSTFV.IDPltGKE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP31084 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATGVTVVPATATSRQSNQTQQTQPSTLAAPNAVGQSASGSALASPSPAPSPLGGSFHGAA
1083
1142










Molecular Recognition Features






MoRF SequenceStartStop




NANANA