<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30956

Description Mediator complex subunit 14
SequenceMAPVQIGSDGPLVPLGGPVVSGPQPPPPGTPATQGVKLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAILFVDTADRLALLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEEKYVPAKYLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPALPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVVPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTVNDDMKRILSWLQQLKFWLGEQRCRQSVKHLPTVCSDIVHLSNSATHPVGSLSKHKLFIKLTRLPQYYIVVEMLEVPSSPTALQYKYSFLSVSQVEGEDGPMCAQLLQLFKPNLEHLVQDPTTGREARPGTKRKIAGDQGDSEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMAIPNEGVQVEGDGSSHAIRLLKIPPCRDVGEETRRALERSLLDSTIRLQGRNNRTWVAELVLANCPLSSTNSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWKAISQLYQCVLNFSCTLPEMPPYLSQFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSNTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVLQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSSQDARRRSVNEDDNPPSPVGVDVMDSLMNQFQGQQQPQTMRGGAGGVYPPLTSPPPNYLANVTPSPSMMPTQSPGNIHASGSPSGALRAPSPFGPTPSPSSLGIAMGQTSFASPHGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPNSPRAGSSSQVMPTSMPPPRKLPQRPWAASIPTILSHNALHVLLLPSPTPCMVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEATLSIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENAGPWSQEELQVLERFFETRVAGPPFKFNTLSAFTKLLGAPTNVLRDCVRIMKLELFPDQAGQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKAKMLFFLQLTQRIPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALLVSNILKRFNELHPSRQGECTIFASVQELMASLSLPPSTRQ
Length1435
PositionTail
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.06
Grand average of hydropathy-0.177
Instability index50.92
Isoelectric point8.66
Molecular weight158701.67
Publications
PubMed=23542700

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     254.65|      38|      38|     973|    1010|       1
---------------------------------------------------------------------------
  973- 1010 (68.75/32.79)	SPVGVDVMDSLMNQFQGQQQPQTMR..GGAGGVYPPLTSP
 1022- 1046 (29.42/ 9.61)	........PSMM....PTQSPGNIHasGSPSG...ALRAP
 1047- 1077 (55.51/24.99)	SPFGPTPSPSSLGIAMGQTSFASPH..G.......PLDPS
 1078- 1111 (65.78/31.04)	SPYTM.VSPSHRGQWPG..SPQ.VS..GPSPGARIPGMSP
 1120- 1140 (35.21/13.03)	IP.................DPNSPR..AGSSSQVMPTSMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.95|      52|      95|     751|     810|       2
---------------------------------------------------------------------------
  751-  810 (84.04/63.67)	EMFlNDWKAISQ....LY..QCVLNFSCTLPEMPPY.LSQFSEVrlyNYRklvlCYGTTKGSSVTIQ
  844-  902 (80.91/43.61)	EMF.NKNPNVLQllqvLYdtQAPLNAINKLPTVPMLgLTQRTNT...AYQ....CFSILPQSPTHIR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     355.94|     105|     440|     149|     256|       3
---------------------------------------------------------------------------
  149-  256 (167.03/125.83)	TTGSYPRlPTCIRdKII....PPDPiTKTEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGD..GRALVHSL
  542-  588 (32.77/14.20)	.........................................................LEVPSSPTALQYKYSFLSVSQVEGEDGPMCAQLLQLEHLVQD...............
  590-  692 (156.13/104.59)	TTGREAR.PGTKR.KIAgdqgDSEP.KKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMAIPNEG.....VQVEGDGSSHAIRLLKIP...PCRDVGEetRRALERSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.80|      58|     149|     282|     343|       4
---------------------------------------------------------------------------
  282-  343 (94.83/73.25)	CLHSFCLSLQLEvLHSQTL..MLI...RERWGDLvqeEKYVPAKYLTLSVWNQQV...LGRKTGTASVHK
  433-  498 (91.97/59.48)	CGRSECLHIFVD.LHSGMFqpMLYgldQSMLDDI...EKTVNDDMKRILSWLQQLkfwLGEQRCRQSVKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.06|      10|      20|    1145|    1155|      10
---------------------------------------------------------------------------
 1145- 1155 (16.32/11.17)	LPQrPWAASIP
 1168- 1177 (21.74/10.44)	LPS.PTPCMVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.15|      22|      24|    1314|    1337|      12
---------------------------------------------------------------------------
   23-   47 (35.02/14.31)	PQPPPPGTPATQgvkLSLLIEFLLQ
 1326- 1350 (35.13/20.15)	PSAPPIAPPGTIavvLKAKMLFFLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.29|      13|      22|    1351|    1363|      13
---------------------------------------------------------------------------
 1351- 1363 (23.87/13.15)	LTQRIPVPQDPVS
 1376- 1388 (23.42/12.75)	LTQQADIPRQHSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30956 with Med14 domain of Kingdom Metazoa
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