<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30946
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MTSHPFVVERDANMATLAEKSTKERLLSVLDDLEVLSRELIEMLALSRSQKLPQPGEDTQILELLVQRDKEFQELMEVAQQQGKVHQEMQVLEKEVEKRDSDIQQLQKQLKEAEHILATAVYQAKEKLKSIEKARKGSISSEEIIKYAHRISASNAVCAPLNWVPGDPRRPYPTDLEMRSGMLGHMANLPSNGMNGHLPGDALAAGRLPDVLTPHYPWQPSDVSVGMLPPHHGNDFGLEPPGHNKENEDDVEAMSTDSSSSSSDSD |
Length | 266 |
Position | Middle |
Organism | Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae>
Xiphophorus.
|
Aromaticity | 0.03 |
Grand average of hydropathy | -0.650 |
Instability index | 51.95 |
Isoelectric point | 5.05 |
Molecular weight | 29601.97 |
Publications | PubMed=23542700
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30946
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.34| 23| 33| 48| 80| 1
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50- 75 (34.72/39.48) Q.KLPQpgeDTQILELLV.QRDKEFQEL
82- 106 (29.63/ 8.32) QgKVHQ...EMQVLEKEVeKRDSDIQQL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 61.97| 15| 33| 185| 199| 2
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185- 199 (30.31/17.14) HMANLPSNGMNGHLP
215- 229 (31.66/18.15) HYPWQPSDVSVGMLP
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