<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30942

Description Mediator complex subunit 23
SequenceMETQLQSIFEDVVVTLIFFFFRMFMDTPENERTKLISCLGAFRQYWGTLQQDSHEQCVQWIVRFIHSQHSPKRISFLYDCLGMAVETSLLPPRMVCVALISSESLEWERTRLWALTFKLIRKIIGGVDYKGVRDLLKAVLDKIQTIPITVSSAIVQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLYPEGHLSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPTTLRFPLRGMLPYDKDLFEPQTGLLRYVLEQPYSREMVCNMLGLNKQQKQRCPVLEEQLVDLVVYAMERSETEEHFDADIGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLILFFTFPFAHFHRLCLRFLQQSLRNKSLGMSDYKIALLCNAYSTNSDCFSLPMGVLVETIYGNGSMRINLPGTSCMASGSVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIHGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMANENDIITHFSMQGSPPLFLCLLWKMLLETDRINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPSDFRNRVNDFVKENAPEHWLQSDWHNKHMNYHKKYPEKLYFEGLAEQVSPPLQLQTQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKFGMNPREDNVWIPDDTYYCKLIGRLSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIISVLSSPALTSETEWAGDPFALLDFTACHQSYSEMNCSYVLALTHAVWHHSSIGQLSLIPKFLSETLKPIVQTELQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHCQHLSYMDPICDFLYHIKYMYTGDSVKEQVEKIIMTLRPAMKLRLRFITHSSIIETSSAAATASSASASSSSAGTPQPPPSSLSSTSAAASPSSSSQHAHTPM
Length1342
PositionTail
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.10
Grand average of hydropathy0.023
Instability index46.18
Isoelectric point7.59
Molecular weight153181.03
Publications
PubMed=23542700

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30942
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.83|      17|      19|     242|     260|       2
---------------------------------------------------------------------------
  242-  260 (28.23/18.87)	DPTT..LRFPLRGmlPYDKDL
  262-  280 (27.59/12.54)	EPQTglLRYVLEQ..PYSREM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.99|      15|      19|     993|    1010|       3
---------------------------------------------------------------------------
  993- 1010 (23.98/22.98)	MSSLKDNrtpGWCLSETY
 1015- 1029 (30.01/18.32)	MNPREDN...VWIPDDTY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.77|      13|      19|     856|     868|       4
---------------------------------------------------------------------------
  856-  868 (22.72/12.25)	SDFRNRVNDFVKE
  877-  889 (27.05/15.88)	SDWHNKHMNYHKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.93|      16|      21|    1296|    1311|       8
---------------------------------------------------------------------------
 1296- 1311 (26.37/17.87)	SSAAATASSASASSSS
 1320- 1335 (27.56/19.03)	SSLSSTSAAASPSSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     254.51|      61|     548|       5|      79|       9
---------------------------------------------------------------------------
    5-   65 (111.26/63.66)	LQSIFE....DVVVTLI.FFFFRMFMDTPENERTKLISCLGAFRQYWGTLQQDSHEQCVQWI.VRFI
  551-  615 (88.42/47.54)	LPNVFKshawGILHTLLeMFSYRMHHIQPHY.RVQLLSHLHSLAAVPQTNQNQLH.LCVESTaLRLI
  675-  712 (54.83/38.25)	.....K....DILQTIM.SF.......TPHNWASHTLSCFPAPLQAF..FKQNNVPQ..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.03|      17|      87|     382|     400|      11
---------------------------------------------------------------------------
  382-  400 (26.78/19.40)	GSIQKnaLADFLPVMK....LFD
  931-  951 (23.25/10.63)	IVIHR..FLELLPVSKsletLLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.18|      13|      21|    1072|    1085|      13
---------------------------------------------------------------------------
 1072- 1085 (16.97/15.94)	VPGKDVgNALLNVV
 1092- 1104 (24.20/16.55)	VPRENI.TAWMNAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.50|      36|     675|     187|     228|      14
---------------------------------------------------------------------------
  187-  228 (48.71/44.74)	KLYPEGhLSHWLLGSLisDFVDSFRPTaRINSICGRcsLLPV
  893-  928 (66.79/36.62)	KLYFEG.LAEQVSPPL..QLQTQYLPI.YFGNVCLR..FLPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.36|      16|     654|      68|      87|      15
---------------------------------------------------------------------------
   68-   87 (26.65/22.85)	QHSPKrisfLYDCL..GMAVET
  745-  762 (26.71/13.02)	QGSPP....LFLCLlwKMLLET
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30942 with Med23 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SASASSSSAGTPQPPPSSLSSTSAAASPSSSSQHAHTPM
1304
1342










Molecular Recognition Features






MoRF SequenceStartStop




NANANA