<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30940

Description Mediator of RNA polymerase II transcription subunit 8
SequenceMQQREEKQLEASVDSLISLVALTKNALQSFIYKLENEYERLTWPNVLDNFGLLSGQLNTINKMLKNEKTPSFRSQVIIPLVLSQKPDDDLTVLTEQRVPVFSHEIVPDYLRTKPDPEVEEQEKQLSTDAARIGPDVAQKQIQALNKMCSNLLEKLNNPRDDRDAESAASRLNKPSFNPGDTNALVAAVAFGKGLSKCRPPGPMAPGHPGQGPMMSGGPTLQQVTIGGGGGQQAGMGGPGAPQQQGQPGKMPSSIKTNIKSASASMHPYNR
Length270
PositionHead
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.04
Grand average of hydropathy-0.589
Instability index46.52
Isoelectric point7.73
Molecular weight29250.86
Publications
PubMed=23542700

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30940
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.97|      25|      26|      64|      89|       2
---------------------------------------------------------------------------
   64-   89 (39.67/31.26)	LKNEKTPSFrSQVIIPLVLSQKPDDD
   93-  117 (46.29/31.55)	LTEQRVPVF.SHEIVPDYLRTKPDPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.57|      18|     102|     133|     151|       3
---------------------------------------------------------------------------
  133-  151 (29.43/21.63)	GPDVAQKQIQAlNKMCSNL
  237-  254 (36.14/22.28)	GPGAPQQQGQP.GKMPSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.66|      16|      17|     157|     173|       4
---------------------------------------------------------------------------
  157-  173 (23.68/26.13)	NPrDDRDAESAASRLNK
  177-  192 (27.98/23.87)	NP.GDTNALVAAVAFGK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30940 with Med8 domain of Kingdom Metazoa
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