<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30932

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRCNTFADTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGFLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLLEQLQKIAEFYRQCPSQGCSSPLPAMPADVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSLGPGAGGHAAHGILTQQGNALPTTPTSQPAGGNQAQTPFTDFYVCPQHRPLVFGLSCLLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSSLPMPGGNTAFTQQVRAKLREIEEQVKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPCDEPSDDSERKEQDAGSSVKMEDTGLSESMETDHNSSANFDEVSDMFSPPMHCESKGSPSPEKPPQEQDGKSSCKDKGMDPAFPQLYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGNGERWVCLRLTNFTGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHSCLILNPEQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKNKFGEIFSEFCSKVKNSIYCNIDPSDSNMLWDPGFMMETISNPSANNNHSMVGKILNDSPANRYSFVCNVLMEVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDDKSSVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHPAGLDDISDGRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSDDGDNPQRQRIKRILQNMDQWTMRQSSLELQLMIKQSTNNELCSLLENIAKATIEVFQKSAEMNSTDMFVISNSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYNQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGGMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKIAKFEEQQRFLLYHTHLKPKPRSYYLEPLPLPPEEEEPLTPISQEPEKKMMEVVKADKSVAAVASESTKKKPKKKKNPTKGEVSLEPPYRPTRNTQMTKITRPNYPPMDKIYPISYKPQPSMPQNLRQQLFPFVGIICTCRVTICSIFVCCQGYTTYASHMGMQQHPSQGGGIAPSSYVAQNFPGAHPGANPGVVEPLRQMQQRPSGYVHQQAPGYPHNMQNTPRLVSHLKTVLLTHASYSGLFCFKQQAQAQQQQQQQQQQQQQQQQQQQQQQPQQQQQVQPQQVPPQQQVPQQQQQQVSAVPPPGQTQNQGLGMQPLPPQQPMVRSERG
Length2014
PositionKinase
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.07
Grand average of hydropathy-0.425
Instability index53.41
Isoelectric point6.51
Molecular weight225699.57
Publications
PubMed=23542700

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30932
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.16|      15|      15|    1936|    1950|       1
---------------------------------------------------------------------------
 1936- 1950 (32.39/13.16)	QQQQQQQQQQQQQQQ
 1952- 1966 (30.12/11.77)	QQQQQQPQQQQQVQP
 1967- 1981 (29.64/11.48)	QQVPPQQQVPQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.69|      25|      35|    1846|    1878|       2
---------------------------------------------------------------------------
 1846- 1878 (41.27/43.34)	MQQHPSqgGgiapssYVAQNFPG.AHPGAN.PGVV
 1884- 1910 (44.42/24.74)	MQQRPS..G......YVHQQAPGyPHNMQNtPRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.00|      12|      15|     873|     884|       3
---------------------------------------------------------------------------
  873-  884 (23.06/18.00)	IQFIFDLM.EYSL
  890-  902 (14.94/ 8.39)	IDFAIQLLnELSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.88|      34|      34|     682|     715|       4
---------------------------------------------------------------------------
  633-  660 (41.25/19.03)	...SHLPRPRSPCD....EPSDDSE.RKEQDAGSSV
  663-  679 (25.15/ 8.43)	EDTG..LSESM.................ETDHNSSA
  682-  715 (63.78/33.87)	DEVSDMFSPPMHCESKG.SPSPEKP.PQEQDGKSSC
  717-  752 (48.69/23.94)	DKGMDPAFPQLYEQPRHiQYATHFPiPQEESASHEC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.22|      19|      42|    1470|    1488|       5
---------------------------------------------------------------------------
 1470- 1488 (34.11/20.49)	REGLLTSLYNQVQ...QIVTNW
 1510- 1531 (30.10/17.22)	RLNLVGGMFDTVQrstQQTTEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.04|      38|      43|     925|     964|       6
---------------------------------------------------------------------------
  925-  963 (62.47/39.76)	CIVAVLRR.YHSCLILNpEQTAQVFDGLRIVVKSGV....NPAD
  970- 1012 (60.57/29.26)	CILAYLYDlYTSCSHLK.NKFGEIFSEFCSKVKNSIycniDPSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.75|      21|     348|    1442|    1462|       7
---------------------------------------------------------------------------
  244-  260 (27.81/12.10)	..QDGM...LDRH..EFLTWVLEC
 1442- 1462 (38.15/19.34)	QKQKSMSL.LSQQ..PFLSLVLTC
 1800- 1823 (32.80/15.60)	KPQPSMPQnLRQQlfPFVGIICTC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.43|      17|      32|    1156|    1172|      11
---------------------------------------------------------------------------
 1156- 1172 (29.81/17.23)	NAACSEQDSEPGARLTC
 1185- 1201 (25.62/13.69)	NPVPQDDKSSVGIRSSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.89|      17|      32|    1332|    1348|      12
---------------------------------------------------------------------------
 1332- 1348 (30.81/21.24)	ILQNMDQWTMR..QSSLEL
 1363- 1381 (22.08/12.97)	LLENIAKATIEvfQKSAEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.28|      29|      32|    1267|    1295|      14
---------------------------------------------------------------------------
 1267- 1295 (50.36/32.42)	VLKTICQQEWVGERCLKSLSEDSSALQDP
 1296- 1324 (50.92/32.88)	VLVNIQAQRLLQLICYPHRQLDSDDGDNP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30932 with Med12 domain of Kingdom Metazoa
Unable to open file!