<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30924

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAISSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTNHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLSEEEIPDKVASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFSAQFQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQESKIDPYAFVEGDEEFLFPDKKERQNSEREAVKKHKGEDGPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKPANGTDDKSSSKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMSNKEYGSMDITPGGTVLEGNSSSIGTQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEECIYRQSWTVGKLELLPSGPAVPFIKEGDGSTIDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPMQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKFPDELILLLQDQCTNLFSPFGAADQDPFPRIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMKVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQSLITPPQMTSTGNANTPSATLASAASSTMTMTSGVTMSSSVATANSTLTTTSTSSSSSSNLNSGVSSNKLPSFPPFGSINSSATGSMSTQASTVQSGQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKNTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSSLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLSTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2042
PositionMiddle
OrganismMustela putorius furo (European domestic ferret) (Mustela furo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Mustelinae> Mustela.
Aromaticity0.07
Grand average of hydropathy-0.413
Instability index52.54
Isoelectric point5.45
Molecular weight224237.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30924
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|    1015.98|     318|     443|     369|     811|       1
---------------------------------------------------------------------------
   51-  443 (458.63/348.57)	QHQPVYLLSEEHIT....LAQQSNSPFQV...ILSPFGL.NGTLTGQAfkmSDSATKKLI.......GEWKQFYPiSSCLKEMSE......EKQED.......MDWEDDslaAVEVLVAGVRMIYPAcfvlvPQSDI..PTPSSVGSSHCSASCLGVHQVPASTRDpaissvTLT....pPTSPEEVQTVDPQSAQKWVKFSSVsDGFNSDSTN..HHGGKIPRKLANHVVDrvWQECNMNraqNKR..KYSASSGGLSEEE.................IPDKVASWDFVEATQRTnCS..CLRHKNL....KPRN....PGQQGQAPSLSQQQQVLPKHKTNE....KQEksekpqkrpltpfhhrvsvsddvgmdtdsasqrlviSAPdsQVRFsnIRTND.........VAKTPQMHGT.EMANSPQPPPLSphpcdvvDEGVTKTPSTPqsqhfyQMPTP.DPLVPSKP
  508-  890 (477.91/368.71)	KDDPVGPFGQESVTsvteLMVQCKKPLKVsdeLVQQYQIkNQYLSAIA...SDAEQESKIdpyafveGDEEFLFP.DKKERQNSEreavkkHKGEDgpssvtvLSHEED...AMSLFSPSIKQDAPR.....PTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDED......ELT.....PGSKKPANGTDDKSSSKESKTGNL.DPLSCISTAdlHKMYPTPPSLEQHIMG..FSPMNMS...NKEYGSMDITPGGTVLEG.................NSSSIGTQFKIEVDEGF.CSpkPSEIKDFsyvyKPENcqvlVGCSMFAPLKSLPSQCLPPIKLPEeciyRQS..........................wtvgklellpSGP..AVPF..IKEGDgstidqeygPAYTPQTHTSfGMPPSSAPPSNS.......GAGILPSPSTP......RFPTPrTPRTPRTP
 1349- 1484 (79.44/ 8.42)	............................................................................................................................APT.....SQSLITPPQMTSTGNANTPSATLA...SAASSTM......TMTsgvtmSSSVATANSTLTTTSTSSSSSSNL.N..SGVSSN...KLPSFPPFGS............IN...SSATGSMS.TQASTVQSGqlggqqssalqtagisgESSSLPTQPHPDVSEST.................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.10|      27|      43|    1855|    1883|       3
---------------------------------------------------------------------------
 1855- 1883 (40.47/32.45)	PN.NDGADGMGIFDLLDTgDDLDpDIINIL
 1900- 1927 (44.63/25.42)	PHgGDAGKGQGTDRLLST.ESHD.EVTNIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.98|      10|     328|     895|     904|       9
---------------------------------------------------------------------------
  895-  904 (17.79/ 8.85)	PASAQGSVKY
  912-  921 (20.19/11.28)	PASTPSTCRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.94|      23|      36|    1624|    1647|      11
---------------------------------------------------------------------------
 1624- 1647 (38.36/26.20)	CIRlYTPPFILAPVKDKQTELGET
 1663- 1685 (43.59/25.68)	CLS.HDQRWILASCTDLYGELLET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.64|      27|      29|    1701|    1727|      12
---------------------------------------------------------------------------
 1693- 1724 (45.64/31.44)	PNRarrkkGSARRFGLQKLWEWC..LGLVQMSSL
 1725- 1756 (41.00/27.39)	PWR..vviGRLGRIGHGELKDWSslLSRRNLQSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30924 with Med13 domain of Kingdom Metazoa
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