<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30923
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYVPLYELITQFELSKDPDPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSISFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGEPGLTCFTLPENQGALHFSTGWRRRGRINQAWDTSLLSRCPHSPVSKDCKDMKSTSTCLLLLVSNVFLV |
Length | 616 |
Position | Middle |
Organism | Mustela putorius furo (European domestic ferret) (Mustela furo) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Mustelinae>
Mustela.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.183 |
Instability index | 50.66 |
Isoelectric point | 8.33 |
Molecular weight | 68467.36 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30923
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.41| 15| 98| 386| 414| 2
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386- 401 (23.39/32.79) RSLQGTLVSkITFQHP
443- 457 (30.02/ 8.72) CPLSESRFS.ISFQHP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 213.61| 48| 48| 152| 199| 3
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152- 199 (81.37/55.62) KHLKGLVNLYNL..........P..GDNKLKTKMYLALQSLEQ.DLSKMAVMYWKATNAGP
202- 248 (68.35/45.51) KILHGSVG.YLT..........PrsGGHLMNLKYYASPSDLLD.DKTTSPIILHE..NNVP
257- 312 (63.89/42.05) VTIEGTSAMYKLpiaplimgshP..VDNKW.TPSFSSITSANSvDLP..ACFFLKFPQPIP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 92.58| 25| 25| 327| 351| 4
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327- 351 (44.23/28.79) IPLFETQPTYVPLYELITQFELSKD
355- 379 (48.34/32.11) IPLNHNMRFYAALPGQQHCYFLNKD
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