<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30918

Description Mediator complex subunit 14
SequenceMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAAEREDTPVMALLLQQFKENIQELVFRTKPGKQPRTGPKRKLSDDPCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQRALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPASYHSTVSQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQVSASVSGLRRVETGDFETPHQQEWRRPLGKLPAGPLARRRLGGGQGFHAPRTGRQNRPRGM
Length1425
PositionTail
OrganismMustela putorius furo (European domestic ferret) (Mustela furo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Mustelinae> Mustela.
Aromaticity0.07
Grand average of hydropathy-0.249
Instability index51.89
Isoelectric point9.24
Molecular weight158611.41
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30918
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     209.42|      34|      34|     929|     962|       1
---------------------------------------------------------------------------
  929-  958 (50.72/22.40)	...............SLISQL..QP.P..PQQQPFPKQPGSSGAYPLTSP
  959-  994 (41.89/17.15)	PASY..........hSTVSQ...SP.SmmHTQSPGNLHAASSPSGALRAP
  996- 1021 (36.51/13.94)	PASF.................vpTP.P..PSSHGISIGPGASFA....SP
 1022- 1047 (39.43/15.68)	HGT.................L..DPsS..PYTMVSPS..GRAGNWP.GSP
 1048- 1093 (40.86/16.53)	QVSGpspatrmpgmsPANPSL..HS.P.vPDASHSPRAGTSSQTLPTNMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.47|      28|      31|    1361|    1391|       2
---------------------------------------------------------------------------
 1364- 1391 (50.55/31.29)	QVSASVSGLRRVETGD.FETPHQQEWRRP
 1394- 1422 (46.92/20.64)	KLPAGPLARRRLGGGQgFHAPRTGRQNRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.64|      30|      31|     180|     209|       3
---------------------------------------------------------------------------
  180-  209 (48.89/29.47)	RLLKLEILVEDKETGDGRALVH....SMQINFIH
  210-  243 (45.75/27.13)	QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     379.63|     146|     394|     744|     926|       4
---------------------------------------------------------------------------
  264-  313 (44.92/14.28)	HAGKCLSLSV.WN...QQ......VLGRKTGTASVHKVTI.KIDE..N...DVSKPLQIFHDPPLP....................................................................................................................................
  747-  926 (203.00/193.44)	GTTKGSSISIqWNsihQKfhislgTVGPNSGCSNCHNTILhQLQEmfNktpNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYqCFSILPQSSTHIrlaFRNmyCIDIYcrsrGVVAIRDGAYSLFDNSKLVEGFYPA......PG.....LKTFLNMFVdsnQDARRRSVneddnPPS.......PIGGDM
 1212- 1325 (131.71/65.70)	..................................................................LQVLEKFFETRVAGPPFKANTLI.AFTKLLGAPTHI...LRD..CVHIM....KLELFPDQATQLKWNVQFCLTIPPSappiapPGtpavvLKSKMLFFL...QLTQKTSV.....PPQepvsiivPIIYDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.27|      18|      30|    1160|    1179|       5
---------------------------------------------------------------------------
 1160- 1179 (27.61/22.89)	QETLQL.INSNEPGviMFKTD
 1192- 1210 (29.65/17.79)	NQTLQLkVTPENAG..QWKPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.55|      28|      32|     443|     474|       6
---------------------------------------------------------------------------
  443-  474 (41.94/30.39)	IKHLPT..ISSETLQLSNYSTHpignLSKNKLFI
  476-  505 (45.60/23.49)	LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.60|      19|      32|      13|      31|       7
---------------------------------------------------------------------------
   13-   31 (31.17/23.84)	VERKIEIVQFASRTRQLFV
   46-   64 (32.43/25.14)	VEKCAMISSFLDQQAILFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.10|      11|      31|      69|      79|      11
---------------------------------------------------------------------------
   69-   79 (16.90/ 9.25)	RLASLARDALV
  102-  112 (20.20/12.57)	RLPTCIRDKII
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30918 with Med14 domain of Kingdom Metazoa
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