<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30909

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYASINETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSTQSTSTLPTTPAPQPPTSSTTSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKDVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPYRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDNQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVLQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPPTKTEDYGMGPGRSGPYGVTVPPDLLHHTNPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPPYPGVLPTTMTGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQQSQGILGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHAGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQAPMIGAMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQAHQQQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2168
PositionKinase
OrganismMustela putorius furo (European domestic ferret) (Mustela furo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Mustelinae> Mustela.
Aromaticity0.07
Grand average of hydropathy-0.523
Instability index58.02
Isoelectric point6.70
Molecular weight242333.84
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30909
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     225.74|      15|      15|    2026|    2040|       1
---------------------------------------------------------------------------
 2026- 2040 (35.98/12.37)	QQQQQQQQQQQ....QQQQ
 2042- 2056 (35.98/12.37)	QQQQQQQQQQQ....QQQQ
 2057- 2075 (30.38/ 9.37)	QQQQQQQQQQQyhirQQQQ
 2076- 2090 (30.12/ 9.24)	QQILRQQQQQQ....QQQQ
 2091- 2105 (35.98/12.37)	QQQQQQQQQQQ....QQQQ
 2108- 2122 (32.42/10.47)	QQQQQQQAAPP....QPQP
 2123- 2137 (24.88/ 6.43)	QSQPQFQRQGL....QQTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.44|      16|      17|    1793|    1808|       2
---------------------------------------------------------------------------
 1777- 1796 (19.31/ 6.30)	PPSTEERkkksTKGKKRSQP
 1797- 1812 (31.12/15.35)	PTKTEDY....GMGPGRSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     293.90|      53|      56|    1903|    1958|       3
---------------------------------------------------------------------------
 1823- 1881 (79.03/32.76)	HHTNPGSISHLSYRQGSIGLYTQNQPLPAG..GPRVDPYRP.VRLPMQKLPtrppypGVLPT
 1882- 1924 (66.89/28.28)	...TMTGVMGLEPS.....YKTSVYRQQ....QPAVPQGQR.LRQQLQQSQ......GILGQ
 1928- 1974 (73.39/35.14)	HQMTPSSSYGLQTSQGYTPYVSHVGLQQHA..GPADPT..RhLQQR..PS.......GYV..
 1975- 2025 (74.59/30.31)	HQQAPTYGHGLTSTQRF....SHQTLQQAPmiGAMTPLGAQ.GVQAGVRSA......SILPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.20|      25|      46|     346|     370|       4
---------------------------------------------------------------------------
  346-  370 (47.16/32.32)	PFSDLLMCPQHRPLVFGLSCILQTI
  394-  418 (46.04/31.33)	PLDHLPIAPSNLPMPEGNSAFTQQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.20|      16|      17|     639|     655|       5
---------------------------------------------------------------------------
  639-  655 (23.73/16.59)	DDPAdDSERKEAEGSSS
  659-  674 (29.48/16.06)	EDPG.LSESMDIDPSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     321.48|     112|     229|     217|     336|       6
---------------------------------------------------------------------------
  217-  287 (105.80/50.40)	....................................................................................................................................................................GSTIGPLP..HDVEV....AIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLL..RYSGE
  288-  333 (33.05/22.78)	FVQSAYLSRRLAYFCTRRLalqldGVSSHSSHVMSTQSTS.TLPTTP....................................................................................................................................................................................................
  451-  520 (75.50/33.40)	...............................................apqpptssttstpfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeataGFTIGRVL..HTLEVldshSFERSDFSNSL......DSLCNRIFGLGPSKDGHE.ISSDDDAVVSLLCEWAVscKRSGR
  524-  606 (107.13/52.94)	MVVAKLLEKRQAEIEAERC.....GESEAADEKGSIASGSlSAPSAP.............................................................................................................................ifQDV.......LLQF.LDTQAPMLTDPRSESERVEFFNLVLLFCELIR......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.81|      32|      58|    1042|    1099|       7
---------------------------------------------------------------------------
 1065- 1098 (55.19/77.61)	GHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLK
 1261- 1299 (47.61/15.31)	GRRQGGR..NISVETASLDVYAKYVlrsicQQEWVGerCLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.53|      25|      49|     675|     699|       8
---------------------------------------------------------------------------
  675-  699 (45.09/24.37)	VLFEDMEKPDFS...LFSPTMPCEGKGS
  701-  724 (24.32/ 9.49)	....SPEKPDVEkdvKPPPKEKIEGTLG
  725-  748 (42.12/22.25)	VLYDQPRHVQYA...THFP.IPQEESCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     302.10|      76|     230|    1143|    1219|       9
---------------------------------------------------------------------------
 1143- 1219 (122.65/84.94)	LLEDLIRcAAIPSLLNAACSEQDSEPGARLTCRILLHLFKT.PQLNPCQSDG...NKPTVG.IRSSCDRHLLAASQNRIVDG
 1300- 1360 (87.62/53.87)	............SLCEDSNDLQDPVLSSAQAQR.LMQLICY.PYRLLDNEDG...ENPQ....RQRIKRILQNLDQWTMRQS
 1379- 1455 (91.84/57.20)	LLENIAK.ATIEVFQQSA..ETGSSSGS..TASNMPSSSKTkPVLSSLERSGvwlVAPLIAkLPTSVQGHVLKAAGEELEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.57|      16|      17|     860|     876|      10
---------------------------------------------------------------------------
  860-  876 (26.03/20.23)	FALgMSYHLPLVQHVQF
  878-  893 (28.55/16.72)	FDL.MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.58|      14|      17|    1665|    1681|      11
---------------------------------------------------------------------------
 1665- 1681 (16.87/19.60)	KIAGFDsIFkkEGLQVS
 1685- 1698 (28.71/17.67)	KISPWD.LF..EGLKPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.72|      15|      17|    1733|    1748|      12
---------------------------------------------------------------------------
 1733- 1748 (27.59/18.56)	PrPRAYYLEP...LPLPPE
 1752- 1769 (26.13/12.37)	P.PAPTLLEPekkAPEPPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      17|    1028|    1040|      13
---------------------------------------------------------------------------
 1028- 1040 (25.11/13.45)	ENPAA.HTFTYTGL
 1046- 1059 (21.03/10.20)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1562|    1575|      14
---------------------------------------------------------------------------
 1562- 1575 (24.50/15.74)	LLEIIISGTV..DMQS
 1586- 1601 (20.20/11.64)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.24|      16|     185|     623|     638|      15
---------------------------------------------------------------------------
  623-  638 (34.09/16.26)	GDLAF..GAPGPR....PPSPF
  803-  824 (21.15/ 7.37)	GDLTFlgGEDGQKrrrnRPEAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.15|      30|      52|    1466|    1497|      17
---------------------------------------------------------------------------
 1466- 1497 (46.68/31.86)	RDRQ...KQKSMSLLSQQpfLSLVLTCLKGQ.DE.QR
 1516- 1550 (40.47/20.68)	RDNQyldDCKPKQLMHEA..LKLRLNLVGGMfDTvQR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30909 with Med12 domain of Kingdom Metazoa
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