<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30908

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMALPHPFWSAPSPHPPRHERWEKGQGSGYSLGGHRKVSSWGPETPYPTGQCAGRHFPQFLLGFRRGGGASDGFRVWAWRCGRGGGGGRTGRGRSGATGMDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGPSGMAPHGMAVVSTAAPQTQLQLQQVALQQQQQQFQQQQVALQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length845
PositionTail
OrganismMustela putorius furo (European domestic ferret) (Mustela furo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Mustelinae> Mustela.
Aromaticity0.04
Grand average of hydropathy-0.740
Instability index83.71
Isoelectric point9.72
Molecular weight92848.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30908
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.19|      19|      19|     259|     277|       1
---------------------------------------------------------------------------
  263-  284 (33.72/ 7.17)	QQFQQ.QQVALQQQQQqqqQQQQ
  500-  519 (31.46/ 6.02)	QTPQSmPPPPQPSPQP...GQPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.05|      19|      19|     311|     329|       4
---------------------------------------------------------------------------
  304-  324 (31.22/ 6.27)	QQQQQlqQQQQQQQHLIKLHH
  325-  344 (31.83/ 6.54)	QNQQQ.iQQQQQLQRMAQLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.91|      12|      34|     250|     261|       6
---------------------------------------------------------------------------
  250-  261 (22.70/ 7.18)	QLQLQQVALQQQ
  286-  297 (23.45/ 7.78)	QFQAQQNAMQQQ
  451-  462 (21.76/ 6.44)	QPQVQQVQPQVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.72|      41|     137|      47|     101|       7
---------------------------------------------------------------------------
   47-  101 (70.22/65.56)	PTGQCAGRHFPQfllgfrRGGGASDGfrvwawrcGRGGGG.........GRTGRGRSG..ATGMDV
  190-  241 (72.50/38.09)	PAAGAAGIGMPS......RGPGQSLG........GMGGLGtmgqpmplsGQPPPGPSGmaPHGMAV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.12|      19|     138|     405|     429|       8
---------------------------------------------------------------------------
  405-  423 (35.71/ 6.54)	QPSQLPPQSQTQPLVSQAP
  560-  578 (28.41/ 8.66)	VPSPGPLNTPVNPSSVMSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.64|      33|      36|     602|     637|       9
---------------------------------------------------------------------------
  606-  639 (53.97/38.89)	MINKIDKNEDrKKDLSKMKSL.LDILTDPSKRCPL
  642-  662 (29.01/12.64)	L....QKCEI...ALEKLKND.MAVPTPP......
  763-  792 (46.66/23.02)	LICKLD.....DKDLPSVPPLeLSVPADYPAQSPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.66|      20|      47|     471|     495|      10
---------------------------------------------------------------------------
  468-  487 (34.24/10.97)	PTA.........................QASQIVGSGVQVSQNSL
  493-  537 (25.42/15.49)	PSPgqqvqtpqsmppppqpspqpgqpssQPNSNVSSGPAPSPSSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.01|      44|     125|     670|     713|      11
---------------------------------------------------------------------------
  670-  713 (79.29/55.41)	KQ.QYLCQPLLDAVLANIRSPVF....NHSLYRTFVPAMTAIHGPPITA
  796-  844 (67.72/46.11)	RQwQYDANPFLQSVHRCMTSRLLqlpdKHSVTALLNTWAQSIHQACLSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30908 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALPHPFWSAPSPHPPRHERWEKGQGSGYSLGGHRKVSSWGPETPYPT
2) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGPSGMAPHGMAVVSTAA
3) QQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLVRTPMVVQQPQVQPQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2
168
348
48
246
595










Molecular Recognition Features






MoRF SequenceStartStop




NANANA