<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30906

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYNDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGDSGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCVEQDTPGQKLGLGGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGVRPSNPESSDKWWHSYRLPRIDDAEFRPPELQGDRCDAKMEVNSESTALQRLLAQPNKRFKIWQEKQPQMQPLHFLDPLPLAQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGAEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFKMEVEDGLGSPKPEEVKDFSYVHKAPTFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAAIFNRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFLPQMEGTRKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGCDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQSPPAAAQGQATPGNAGPLASNSGSAAPPAGSAFNPTSNSTSGNPAASSSASGSSVPPPVSSSAPAAVVNQTSTTSSSGFSASVGGQNPSTGASSADRMQGNMGCGGDTEPGQSSSQSSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2211
PositionMiddle
OrganismMustela putorius furo (European domestic ferret) (Mustela furo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Mustelinae> Mustela.
Aromaticity0.07
Grand average of hydropathy-0.384
Instability index57.65
Isoelectric point5.67
Molecular weight242733.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30906
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     149.01|      27|      28|    1531|    1557|       1
---------------------------------------------------------------------------
  331-  352 (29.28/11.36)	PEQAVIGDSGGTQSA..VSHLGSQ...
 1531- 1557 (46.86/23.18)	PPAAAQGQATPGNAGPLASNSGSAAPP
 1563- 1586 (39.11/17.97)	NPTS...NSTSGNPAASSSASGSSVPP
 1592- 1617 (33.76/14.38)	APAAVVNQTSTTSSSGFSASVGGQNP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.62|      28|      28|    1033|    1060|       2
---------------------------------------------------------------------------
 1002- 1032 (35.60/13.71)	SVGSLADPdylNTPQMNTPVTLNS.AAPASNS
 1033- 1060 (49.26/22.09)	GAGVLPSP...ATPRFSVPTPRTP.RTPRTPR
 1061- 1089 (36.77/14.43)	GGGTASGQ...GSVKYDSTDQGSPaSTPSTTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1126|    1150|       3
---------------------------------------------------------------------------
 1126- 1150 (51.64/31.61)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1153- 1181 (36.91/20.48)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.86|      27|      28|    2071|    2098|       4
---------------------------------------------------------------------------
 2071- 2098 (41.86/30.59)	HFQhSRSQGERL...LSREAPEELKQQPLAL
 2100- 2129 (46.00/28.38)	YFV.STAKAENLpqwFWSSCPQAQNQCPLFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.17|      12|      28|    1634|    1645|       5
---------------------------------------------------------------------------
 1634- 1645 (23.14/12.59)	GGDTEPGQSSSQ
 1661- 1672 (23.03/12.48)	GIPTEPDSADSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      12|      28|     542|     553|       6
---------------------------------------------------------------------------
  542-  553 (24.80/10.36)	NPMDSPHSPISP
  568-  579 (22.89/ 8.97)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.64|      15|      28|    1850|    1876|       7
---------------------------------------------------------------------------
 1850- 1864 (27.99/ 7.94)	ELLETC..IVNI.ALPNR
 1879- 1896 (24.65/25.29)	KLWEWCigIVQMtSLPWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.64|      20|      21|     955|     975|       8
---------------------------------------------------------------------------
  955-  975 (33.85/20.49)	LPSQcLLPLKIPDACLF.RPSW
  977-  997 (31.79/13.60)	IPPK.IEQLPMPPAAIFnRDGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.42|      18|      22|    1698|    1717|       9
---------------------------------------------------------------------------
 1698- 1717 (30.77/25.92)	NFWLLSLMRC.YteMLDNLPE
 1721- 1739 (29.64/17.89)	NSFILQIVPCqY..MLQTMKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.19|      18|      22|    2001|    2018|      10
---------------------------------------------------------------------------
 1977- 1993 (21.38/ 8.23)	.TALNMQSS...QLNTPQDAS
 2001- 2018 (31.10/15.38)	PTSSTIQVA...PANYPNEDG
 2021- 2041 (26.70/12.14)	PNNDDMFVDlpfPDDMDNDIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.81|      17|      22|    1375|    1391|      11
---------------------------------------------------------------------------
 1375- 1391 (33.62/16.68)	SPEPLPI.PTLLV...GCDKD
 1396- 1416 (23.20/ 9.18)	SPFSLPFwERLLLdpyGGHRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.71|      24|     111|     689|     714|      12
---------------------------------------------------------------------------
  689-  714 (37.92/30.98)	MQP.LHFLDPLpLAQQPGDSLGEVNdP
  802-  826 (38.79/21.11)	LAPsLHDLDNI.FDNSDDDELGAVS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.52|      20|      23|      65|      84|      13
---------------------------------------------------------------------------
   65-   84 (38.38/22.96)	QANLLCVWRRDVKPDCKELW
   91-  110 (35.14/20.42)	EPNLVGVIHHELQVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.55|      11|      22|    1231|    1241|      14
---------------------------------------------------------------------------
 1231- 1241 (20.74/10.59)	QHTQPFASLSF
 1250- 1260 (22.81/12.46)	RQTLPCVSWSY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.44|      34|     112|     358|     393|      15
---------------------------------------------------------------------------
  358-  393 (59.90/41.93)	TMHSPKRSGKIP..PKLHNHmvHR..VWKE.CILNRTQSKR
  468-  506 (48.54/27.44)	TTERPEKGDKLQkrPLIPFH..HRpsVADEfCVEQDTPGQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1265|     156|     189|      16
---------------------------------------------------------------------------
  156-  189 (52.23/51.59)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1424- 1455 (59.04/46.72)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      14|      17|     225|     240|      18
---------------------------------------------------------------------------
  225-  238 (24.00/19.86)	YKMSDPATRKLIEE
  243-  256 (23.41/ 9.59)	YPMVLKKKEELKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      12|     298|     127|     138|      19
---------------------------------------------------------------------------
  127-  138 (23.47/13.52)	HNLLERCLMDKN
  428-  439 (23.32/13.39)	HKLLKRCAVGPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.01|      16|      17|     888|     903|      22
---------------------------------------------------------------------------
  888-  903 (27.45/19.63)	SETVTALGM.MESPMVS
  906-  922 (22.56/14.58)	STQLTEFKMeVEDGLGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30906 with Med13 domain of Kingdom Metazoa
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