<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30905

Description Mediator complex subunit 12 like
SequenceMAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLEWTQISTRYLREQLAKISDFYHMASSAGDGSVPVPPDVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHMMIGPNSSSIGAPSPGPPGPVMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAIAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDDHYPKDHDMKMEEQTIMAHMGLDSGTTNIFDEVDKNDFKTDFGSEFPIFSPMPGESCENANSSLGRRMSVNGEKLLKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGVGDEGPKARKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNVSSLKNDDFTMRGLRRDGNTDDIWTASQNPKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNSNSSNSGMGLFNPNGIGNTDTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMLHHPQSTLWGYNLMGQPQQPSFFLQNQSLTPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLIQMKLLQQQQQQRLLRQAQARPFQQDFCNSAVSLLEDFDNIMGPPGDQAALFAAQARPSPQLSQYPGLQQAQTMPQGYTMYGTQMPLPQTPQQQAGGVLLSPNYNSRTYPAAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLPGSQRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPPQPQQPPQPQSQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2190
PositionKinase
OrganismMustela putorius furo (European domestic ferret) (Mustela furo)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Mustelidae> Mustelinae> Mustela.
Aromaticity0.07
Grand average of hydropathy-0.424
Instability index56.78
Isoelectric point6.99
Molecular weight245000.35
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:Ensembl

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30905
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|      95.21|      13|      19|    1814|    1826|       1
---------------------------------------------------------------------------
 1844- 1856 (21.88/11.03)	QSTLWGYNLMGQP
 1913- 1925 (16.93/ 6.17)	QQQLIQMKLLQQQ
 2112- 2124 (20.39/ 9.57)	QQRLLQMQQPPQP
 2131- 2142 (18.66/ 7.87)	QSQTLGLQAM.QP
 2143- 2155 (17.35/ 6.58)	QQPLFPRQGLQQT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     204.01|      42|      44|     917|     958|       2
---------------------------------------------------------------------------
  899-  927 (29.62/14.95)	.LLLKSSSLAGSYtTGLC.............................vC.IVAVL.RRYHS
  928-  973 (63.99/42.28)	CLILNPDQTAQVF.EGLCGVVKHV..VNPS....ECSS.......perC.ILAYLyDLYVS
  974-  996 (23.73/10.27)	CSHLRS.KFGDLF.SSACSKVKQT..I..................................
 1077- 1118 (58.16/37.65)	CTVLSSEWLG.VL.KALCCSSNHVwgFNDV....LC.T..........V.DVSDL.SFHDS
 1131- 1176 (28.51/14.06)	C...........F..SLEDVVQHV..ALPSllaaACGDadaepgarmtCrLLLHLfRAPQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     340.33|     111|     201|    1767|    1904|       3
---------------------------------------------------------------------------
 1767- 1904 (174.15/118.57)	PPEEE......EEEPTSPVSQEPERKSAELSDQGKTTTDEEkktkgrkrktKSssrVDEYPQSNIYRV..PPNYSPISSQMLHHPqstlwgynlmgqpQQPSFFLQNQS......LtPGGSRLD....PTGSFVP.......TNTKQALSNM.LQRRSGAMMQP
 1960- 2107 (166.18/89.34)	PPGDQaalfaaQARPSPQLSQYPGLQQAQTMPQGYTMYGTQ..........MP...LPQTPQQQAGGVllSPNYNSRTYPAAHSN..palmerlrqmqQQPSGYVQQQAspylqpL.PGSQRLNhqslQQSPLVGggidavlTSTHPSLPSVpLPQDPMRPRQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.08|      19|     201|      21|      45|       4
---------------------------------------------------------------------------
   21-   45 (27.66/32.15)	PPDVyPQDPKQKEdeltaVNVKQGF
  220-  238 (38.43/23.48)	PPDV.EQAMKQWE.....YNEKLAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.58|      13|      35|    1407|    1419|       5
---------------------------------------------------------------------------
 1407- 1419 (23.70/15.62)	SNSSNSGMGLFNP
 1440- 1452 (21.88/13.74)	SSSERRGVWLVAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     373.68|     125|     156|     542|     676|       7
---------------------------------------------------------------------------
  542-  657 (163.46/130.99)	.........................................ERCGES....E.VLDEKESISS.ASLAGSSLP...VF.QNV.LLRFLDTQAPSLSDPNSECEKVEFVN.LVLLFCEFIRHDVFSHdAymCTLISRGDLSVTAStrpRSPAGENVDDHYPKDHDMKMEE
  658-  814 (163.99/121.96)	QTIMAHMGLDSgttnIFDEvdkndfktdfgsefpifspmpgESCENA....NsSLGRRMSVNG.EKLLKREKPrelIFpSNYdLLRHLQ.YATHFPIPLDESSSHECNQrTILLYGVGKERDEARH.Q..LKKITKDILKILNK...KSTTETGVGDEGPKARKNKQEA
  819-  876 (46.22/23.34)	ETVFTKLQLLS....YFDQ......................HQV.TSqisnN.VL...EQITSfASGTSYHLP...LA.HHI.QLIF.DLMEPAL..........................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.11|      13|      30|    1295|    1307|       8
---------------------------------------------------------------------------
 1295- 1307 (23.66/14.30)	CLKEPERLCTDKE
 1327- 1339 (25.45/16.01)	CYPHGIKECTEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     102.17|      24|     183|    1513|    1536|       9
---------------------------------------------------------------------------
 1354- 1373 (31.39/16.84)	EQWT..LRQSWL.ELQLMIK.............QCL...
 1513- 1536 (41.45/24.82)	GQDE..QREGLLTSLQNQVN.............QILSNW
 1541- 1579 (29.32/15.20)	YQDDikARQMMHEALQLRLNlvggmfdtvqrstQWTTDW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.48|      21|     182|    1056|    1076|      13
---------------------------------------------------------------------------
 1056- 1076 (37.09/22.00)	GHQDAGRINDIANFSSELTAC
 1243- 1263 (39.38/23.81)	GLRRDGNTDDIWTASQNPKSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.65|      39|     182|    1471|    1509|      14
---------------------------------------------------------------------------
 1471- 1509 (62.37/39.11)	EELEKGQHLGSSSKKERD....RQKQKSMSLLSQQPFLSLVLT
 1652- 1682 (52.46/31.52)	ESIDKVRQLLPLPKQTCD............VITCEPMGSLIDT
 1691- 1727 (44.81/25.66)	DSIDKKQGLQVSTKQKVSpwdlFEGQKNPAPLSWAWF......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.60|      19|     293|     386|     411|      15
---------------------------------------------------------------------------
  386-  411 (27.41/25.24)	NDNKSaNPGSPLDLLQvapsslPMPG
  680-  698 (39.19/18.18)	NDFKT.DFGSEFPIFS......PMPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30905 with Med12 domain of Kingdom Metazoa
Unable to open file!