<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30892

Description Mediator complex subunit 12
SequenceMGNPVPARARRGGRLPPQGVAPRGTLSGSRTFRRYLGNEIDLEPRGPKCSAAAELRPTPGWAPPPLQSVLSDGSRRPSVPLGSFRQRSRVSNVPPVVSRLPSSQPPPPFSVPSPPPPSAGPGWRLWRYGLGKMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPTPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLSTRPPYPGVMPTAMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHAGPADPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQAAAAQQQQQQPQQQQQQQQQQYHIRQQQQQQILRVRPWDGSWALRASGGEEAASASRSSSSRSFLLAEWLWQAAGA
Length2253
PositionKinase
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.07
Grand average of hydropathy-0.449
Instability index56.42
Isoelectric point7.81
Molecular weight249922.18
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30892
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     169.67|      20|      20|    2168|    2187|       1
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 2039- 2060 (22.26/ 8.72)	PQGQRLRQQLQAKIQSQGmlGQ
 2106- 2125 (24.85/10.77)	PSGYVHQQAPTYGHGLTS..TQ
 2126- 2145 (24.38/10.41)	RFSHQTLQQTPMIGTMTP..LG
 2146- 2165 (24.77/10.71)	AQGVQAGVRSASILPEQQ..QQ
 2168- 2187 (35.81/19.46)	QQQQQQQQQQAAAAQQQQ..QQ
 2189- 2208 (37.60/20.88)	QQQQQQQQQQYHIRQQQQ..QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     151.86|      30|      56|    1950|    1980|       2
---------------------------------------------------------------------------
  837-  862 (38.15/15.55)	PDVEKEVKPP.....PKEKI...E...........GTLGvL.........Y..DQP
 1951- 1980 (56.12/33.31)	PDLLHHANPG.....SISHLSYRQ...........GSIG.L.........YTQNQP
 1982- 2036 (33.24/12.00)	PAGGPRVDPYrpvrlPMQKLSTRPpypgvmptamtGVMG.LepssyktsvYRQQQP
 2063- 2080 (24.34/ 8.48)	...VHQMTPS.....S....................SYG.L.........QTSQGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.27|      29|      37|     270|     299|       3
---------------------------------------------------------------------------
  270-  299 (48.22/38.55)	KKEEVFGYLAKYTVPVMRAAW..LIKMTcAYY
  308-  338 (51.04/34.60)	KKRHVIDPFMEWTQIITKYLWeqLQKMA.EYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.41|      32|      58|    1174|    1231|       4
---------------------------------------------------------------------------
 1197- 1230 (56.15/73.48)	GHHDPDRvnDIAILCAELTGYCKSL.....SAEWLG..VLK
 1393- 1431 (45.27/12.40)	GRRQGGR..NISVETASLDVYAKYVlrsicQQEWVGerCLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.44|      14|      15|     994|    1008|       5
---------------------------------------------------------------------------
  994- 1008 (22.19/19.24)	LgMSYHLPLVQHVQF
 1012- 1025 (24.25/14.88)	L.MEYSLSISGLIDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.23|      34|      37|     541|     577|       6
---------------------------------------------------------------------------
  541-  577 (54.04/44.85)	EGNSAFT.QQVRAKLREIEQQIKERGqavEVRWSFDK.C
  579-  614 (49.20/32.52)	EATAGFTiGRVLHTLEVLDSHSFERS...DFSNSLDSlC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.91|      16|      16|     777|     792|       7
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  777-  792 (25.61/13.53)	SERKEAEGSSSSKLED
  796-  811 (26.92/14.69)	SESMDIDPSSSVLFED
  821-  835 (23.37/11.54)	SPTMPCEGKGSPSPE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.71|      14|      15|    1867|    1880|       8
---------------------------------------------------------------------------
 1867- 1880 (27.50/12.66)	PRAYYLEPLPLPPE
 1885- 1898 (24.79/10.56)	PAPTLLEPEKKAPE
 1899- 1910 (19.42/ 6.41)	P.PKTDKPGAAPP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.37|      40|      43|      59|     101|       9
---------------------------------------------------------------------------
   22-   62 (37.79/20.52)	P...RGTLS.GSRTFRRYLG............................NEID.LEPRGPkcsaaaelrptpgwA
   63-  104 (68.26/32.90)	PPPLQSVLSDGSRRPSVPLG.................SFRQR..SRVSNVPP.VVSRLP............ssQ
  105-  161 (53.32/23.14)	PPPPFSVPSPPP..PSAGPGwrlwryglgkmaafgilSYEHRplKRPRLGPPdVYPQDP...............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.14|      24|      58|    1510|    1533|      10
---------------------------------------------------------------------------
 1510- 1533 (40.25/26.98)	SLLEN.........IAK...........ATIEVFQQSAETGSSS
 1551- 1594 (24.90/13.50)	SSLERsgvwlvaplIAKlptsvqghvlkAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1160|    1172|      11
---------------------------------------------------------------------------
 1160- 1172 (25.11/12.66)	ENPAA.HTFTYTGL
 1178- 1191 (21.03/ 9.56)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.53|      31|      44|    1058|    1099|      19
---------------------------------------------------------------------------
 1058- 1089 (52.92/52.03)	CIVAVLRH.YHACLILnQDQMAQVFEGLCGVVK
 1103- 1134 (53.61/26.64)	CILAYLYDlYTSCSHL.KSKFGELFSDFCSKVK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30892 with Med12 domain of Kingdom Metazoa
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