<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30879

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSSFVPNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISSCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSSVGSSHCSASCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLSEEEIPDKIASWDFVEATQRTNCSCLRHKNLKPRNPGQQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGIDADSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPAQFQEAVEPTIYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDELVQQYQIKNQYLSAIASDAEQESKIDPYAFVEGDEEFLFPDKKDRQNSEREAVKKHKVEDGPSSVTVLSHEEDAMSLFSPSIKQDAPRPTSHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSANGTDDKSSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMSNKEYGSMDITPGGTVLEGNSSTVGTQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKSLPSQCLPPIKLPEECIYRQSWTVGKLELLSSGPAVPFIKEGDGSTIDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPMQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTECGKEAEKRFEALRATSAEHVNGGLKESEKFPDELILLLQDQCTNLFSPFGAADQDPFPRIGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPISRLLTDGIMRVGSTASKKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAMSSSVATANSTLTTTSTSSSSSSNLSSGVPSNKLPSFPPFGSMNSSATGSMSTQASTVQNGQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSSLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2173
PositionMiddle
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.08
Grand average of hydropathy-0.398
Instability index53.03
Isoelectric point5.40
Molecular weight239490.49
Publications
PubMed=17975172

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
triglyceride homeostasis	GO:0070328	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30879
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.62|      58|      67|     872|     934|       1
---------------------------------------------------------------------------
  872-  934 (94.01/75.25)	NSSTVGtqfKIE.VDEGFCSP..KPSEIKDFSYVYKPENC.QVLVGCSMfAPLKSLPSQCLPPIkLP
  941- 1002 (93.61/57.81)	QSWTVG...KLElLSSGPAVPfiKEGDGSTIDQEYGPAYTpQTHTSFGM.PPSSAPPSNSGAGI.LP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     596.66|     128|     712|     731|     871|       2
---------------------------------------------------------------------------
  289-  405 (136.70/81.16)	............DIPT.PSS.........VGSSHCSASCLG..VHQVPASTRDpamssvTLTpPTSPE.EVQ...TVDPQSA.QKWVKFSSVsDG...FNSDSTS..HHG...........GKIPRKLANHVVDrvWQEC.NMNraqNKR..KYSASSGGLSEEE
  431-  539 (85.80/43.47)	........NLK...PRnPGQQGQAPSLSQ.QQQVLPKHKTNekQEKSEKPQKR......PLT.PFHHRvSISddvGIDADSA.SQRLVISAP.DSqvrFSNIRTNDVAK.tpqmhgtemanSPQPPPLSPH..................................
  743-  871 (213.16/128.41)	DAMSLFSPSIKqDAPR.PTSHARPPSTSLIYDSDLAVSYTD..LDNLFNSDED......ELT.PGSKK.SAN...GTDDKSS.CKESKTGNL.DP...LSCISTADLHKM...........YPTPPSLEQHIMG..FSPM.NMS...NKEYGSMDITPGGTVLEG
 1469- 1581 (161.01/90.15)	DSSLLSQPNLV..APT.SQSLITPPQMTNTGNANTP.SAT...LASAASSTM.......TMT.........S...GVAMSSSvATANSTLTT.TS...TSSSSSSNLSSG...........VPS.....NKLPS..FPPFgSMN...SSATGSMS.TQASTVQNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.61|      26|      29|    1014|    1041|       4
---------------------------------------------------------------------------
 1014- 1041 (38.84/25.33)	TPRTPRTPRAGGPASAQgSVKyENSDLY
 1046- 1071 (48.76/23.04)	TPSTCRPLNSVEPATVP.SIP.EAHSLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.62|      30|     712|     625|     661|       5
---------------------------------------------------------------------------
  563-  602 (36.76/13.06)	MPtpdPLVPSKPMEDriDSLSqsfPaqF.QEAVEPT..IYVGT
  629-  661 (47.86/30.08)	LP...PQLPSDKFKD..DPVG...P..FgQESVTSVteLMVQC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.71|      20|      26|    1327|    1348|       6
---------------------------------------------------------------------------
 1327- 1348 (35.42/24.69)	P..EPLPIPTFllGYDYD..FLVLSP
 1352- 1375 (28.29/13.70)	PywERLMLEPY..GSQRDiaYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.91|      13|      35|    1251|    1263|       7
---------------------------------------------------------------------------
 1251- 1263 (24.87/15.43)	DEALVKSSCLHPW
 1289- 1301 (24.03/14.63)	QDAIQKKRTVRPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.99|      15|      26|    1595|    1611|      11
---------------------------------------------------------------------------
 1595- 1611 (19.21/17.90)	GI..SGESSSLpTQPhPDV
 1622- 1638 (24.78/11.29)	GIptDGDSHAI.TYP.PAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.52|      20|    1196|     217|     236|      14
---------------------------------------------------------------------------
  217-  236 (36.03/29.49)	LTGQAFKMSDSATK....KLIGEW
 1410- 1433 (29.50/22.44)	LTDGIMRVGSTASKklseKLVAEW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30879 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CSCLRHKNLKPRNPGQQGQAPSLSQQQQVLPKHKTNEKQEKSEKPQKRPLTPFHHRVSISDDVGIDADSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
2) FPDKKDRQNSEREAVKKHKVEDGPSSVTVLSHEE
3) GSPVHSPGSHYPHGGDAGKGQGTDRLLSTESH
4) NLFNSDEDELTPGSKKSANGTDDKSSCKESKT
5) TIDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRAGGPASAQGS
6) TSGVAMSSSVATANSTLTTTSTSSSSSSNLSSGVPSNKLPSFPPFGSMNSSATGSMSTQASTVQNGQLGGQQSSALQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
7) VAPTSQSLITPPQMTNTGNANTPSATLASAASS
424
709
2020
785
967
1516
1479
587
742
2051
816
1032
1628
1511










Molecular Recognition Features






MoRF SequenceStartStop




NANANA