<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30878

Description Mediator complex subunit 12
SequenceMGNPVPARARRGGRLPPQGVAPRGTLSGSRTFRRYLGNEIDLEPRGPKCSAAAELRPTPGWAPPPLQSVLSDGSRRPSVPLGSFRQRSRVSNVPPVVSRLPSSQPPPPFSVPSPPPPSAGPGWRLWRYGLGKMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVIDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVMSAQSTSTLPTTPTPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLSTRPPYPGVMPTAMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHAGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQAAAAQQQQQQPQQQQQQQQQQYHIRQQQQQQILRVRPWDGSWALRASGGEEAASASRSSSSRSFLLAEWLWQAAGA
Length2261
PositionKinase
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.07
Grand average of hydropathy-0.459
Instability index56.68
Isoelectric point7.97
Molecular weight250775.99
Publications
PubMed=17975172

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30878
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     109.17|      27|      27|    2158|    2184|       1
---------------------------------------------------------------------------
 2012- 2034 (28.70/11.78)	....SVYRQQQPAVPQGQRLR..........QQLQAK
 2124- 2160 (31.51/13.79)	TYGHGLTSTQRFSHQTLQQTPmigtmtplgaQGVQAG
 2161- 2187 (48.97/26.28)	VRSASILPEQQQQQQQQQQQQ..........QQQQAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.27|      29|      37|     270|     299|       2
---------------------------------------------------------------------------
  270-  299 (48.22/38.11)	KKEEVFGYLAKYTVPVMRAAW..LIKMTcAYY
  308-  338 (51.04/34.20)	KKRHVIDPFMEWTQIITKYLWeqLQKMA.EYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.16|      16|      20|    1162|    1178|       3
---------------------------------------------------------------------------
 1162- 1177 (29.43/14.32)	NP..ANRYSFVCNALMHV
 1183- 1200 (20.73/ 8.61)	DPdrVNDIAILCAELTGY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.58|      40|      44|      22|      65|       4
---------------------------------------------------------------------------
   23-   65 (69.14/42.58)	RGTLS.GSRTFRRYLGNeidLEPRGPKCSAAAELRPTPGWAPPP
   67-  107 (66.43/30.08)	QSVLSdGSRRPSVPLGS...FRQRSRVSNVPPVVSRLPSSQPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.53|      31|      44|    1041|    1082|       5
---------------------------------------------------------------------------
 1041- 1072 (52.92/50.23)	CIVAVLRH.YHACLILnQDQMAQVFEGLCGVVK
 1086- 1117 (53.61/25.78)	CILAYLYDlYTSCSHL.KSKFGELFSDFCSKVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.26|      18|      19|    1850|    1867|       6
---------------------------------------------------------------------------
  141-  158 (29.98/12.42)	YEHRPLKRPRLGPPDVYP
 1855- 1872 (31.28/13.33)	LEPLPLPPEDEEPPAPTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.85|      19|      19|     777|     795|       7
---------------------------------------------------------------------------
  777-  795 (30.83/14.64)	SERKEAEGSSSSKLED...PGL
  796-  817 (27.08/11.84)	SESMDIDPSSSVLFEDmekPDF
  821-  839 (32.94/16.21)	SPTMPCEGKGSPSPEK...PDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     152.01|      22|      44|    1921|    1942|       8
---------------------------------------------------------------------------
 1921- 1942 (42.58/20.17)	GPGRSGPY.GVTVPPDLLHHANP
 1948- 1963 (25.93/ 9.27)	LSYRQGSI.G......LYTQNQP
 1968- 1989 (33.76/14.40)	GP.RVDPYrPVRLPMQKLSTRPP
 2077- 2091 (22.67/ 7.14)	.....GPA.GTMVPPS.YS.SQP
 2096- 2114 (27.09/10.03)	HP.STNPT.LVD.PTRHLQQRP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.63|      57|      62|    1475|    1536|       9
---------------------------------------------------------------------------
 1475- 1536 (80.16/63.41)	SSLELQLMIKQTPnnemNSLLENIAKATIEVFQQSAETGSSSGNTASNMPSSSKT....KPVLsSL
 1540- 1600 (87.46/54.90)	GVWLVAPLIAKLP....TSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSllsqQPFL.SL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      15|      19|    1776|    1794|      10
---------------------------------------------------------------------------
 1776- 1794 (14.83/22.91)	TKgNKIAGFDsIFkkEGLQ
 1797- 1811 (30.03/18.21)	TK.QKISPWD.LF..EGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.45|      19|      62|    1212|    1230|      11
---------------------------------------------------------------------------
 1212- 1230 (36.23/18.48)	LKALCC..S...SNNG...TCGFNDLL
 1251- 1271 (25.56/11.06)	LIARQCllL...EDLI...RCAAIPSL
 1272- 1293 (19.66/ 6.97)	LNA.AC..SeqdSEPGarlTCRI..LL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.41|      36|      62|     448|     502|      14
---------------------------------------------------------------------------
  448-  502 (56.21/62.74)	HSShvmsaqststlpttptpqpPTSSTPST..PFSDLLMCPQHRPLVFGLSCILQTI
  513-  550 (61.20/33.00)	HYS...................LTDSRIKTgsPLDHLPIAPSNLPMPEGNSAFTQQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.12|      24|      61|    1298|    1323|      15
---------------------------------------------------------------------------
  874-  902 (36.58/12.49)	PQEESCSHECNQRLVvlfGVGKQRDdaRH
 1299- 1322 (47.54/20.37)	PQLNPCQSDGNKPTV...GIRSSCD..RH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     969|     983|      18
---------------------------------------------------------------------------
  969-  983 (26.85/18.31)	LEQITSFALG.MSYHL
  985- 1000 (23.14/14.67)	LVQHVQFIFDlMEYSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.63|      21|      23|    1668|    1690|      20
---------------------------------------------------------------------------
 1668- 1690 (30.30/30.26)	QQTTewAVL.LLEIIISGTV..DMQS
 1693- 1716 (26.33/16.81)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30878 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLSTRPPYPGVMPTAMTGVM
2) EPRGPKCSAAAELRPTPGWAPPPLQSVLSDGSRRPSVPLGSFRQRSRVSNVPPVVSRLPSSQPPPPFSVPSPPPPS
3) FSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
4) GAPGPRPPSPFDDPADDSERKEAEGSSSSKLEDPGLSESMDIDPSSSV
5) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNF
6) LEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQ
7) MGNPVPARARRGGRLPPQGVAPRGTLSGSRTFRRYLGNEID
8) YVSHVGLQQHAGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTMTPLGAQGVQAGVRSASILPEQQQQQQQQQQQQQQQQAAAAQQQQQQPQQQQQQQQQQ
1852
43
820
760
147
2004
1
2066
2002
118
859
807
196
2061
41
2206










Molecular Recognition Features






MoRF SequenceStartStop




1) SRTFRRYLGNEIDLEP
2) WRLWRYGL
29
123
44
130