<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30875
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDAQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLLISLCHSSNDKKSQKCATEKQSPEDHLYVLEHNLHLLIREFHKQTLSSITMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWNHLRGPFREVQWNKMEGRNFVYKMELLMSALSPCLL |
Length | 605 |
Position | Head |
Organism | Felis catus (Cat) (Felis silvestris catus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.428 |
Instability index | 57.41 |
Isoelectric point | 8.01 |
Molecular weight | 67731.56 |
Publications | PubMed=17975172
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
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GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP30875
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 249.02| 85| 110| 280| 376| 1
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280- 376 (124.37/111.56) PLPKSKP.GspHWQTKLEAAQnVLLCKEIFAQLSREAV..QIKSQIPHIVVKNQIIsqpfpSLQLLIS.....LCHssNDKKSQKCATEKQSPEDHLyvL....EHNLH
393- 489 (124.66/77.86) PHPASAPfG..HKRMRLSGPQ.AFDKNEINSLQSSEGLleKIIKQAKHIFLRSRSI.....QLQLNIGveqirVVH..RDGRVITLSHQEQELQDFL..LsqmsQHQVH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 72.26| 23| 244| 1| 27| 5
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1- 27 (32.92/30.53) MSGVRAVRISIesacEKQVQEVGLDGT
251- 273 (39.34/24.81) LEGSAYIKVSI....QKQAPDIGDLGT
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