<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30871
Description |
Mediator complex subunit 14 |
Sequence | MAPVQLENHQLVPPGGGGGGSGGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTLTSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAAEREDAPVMALLLQQFKENVQELVFRTKSGKPPKTGTKRKLSDDLCPVEPKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQMEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGSSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRMPGMSPANPSLHSPVPDASHSPRAGTSSQTLPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP |
Length | 1454 |
Position | Tail |
Organism | Felis catus (Cat) (Felis silvestris catus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.183 |
Instability index | 51.68 |
Isoelectric point | 8.97 |
Molecular weight | 160612.79 |
Publications | PubMed=17975172
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:Ensembl
transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 IEA:Ensembl
regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
stem cell population maintenance GO:0019827 IEA:Ensembl
|
Interaction
Repeat regions
Repeats |
>MDP30871
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
6| 220.68| 32| 32| 1036| 1067| 1
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10- 32 (35.16/12.88) QL...VP..................PGGGGGGSGGPA...SAPAPPP......
1006- 1026 (24.58/ 6.55) ...............................QQPFPKQPGSSGAYPLTSP.PT
1027- 1063 (48.50/20.86) SYhstVN................qsPSMMHTQSPGNLHAASSPSGALRAPSPA
1064- 1097 (46.62/19.73) SF...VP................tpPPSSHGISIGPGASFASPHGTLDPSSPY
1098- 1123 (36.47/13.66) TM...VS..................PSGRAGNWPGS.PQVSGPSPATR.....
1152- 1199 (29.34/ 9.40) QT...LPtnmppprklpqrswaasiPTIL.THSALNILLLPSPTPGL.VPGLA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 94.64| 30| 32| 246| 275| 3
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246- 275 (48.89/38.33) RLLKLEILVEDKETGDGRALVH....SMQINFIH
276- 309 (45.75/35.32) QLVQSRLFADEKPLQDMYNCLHsfclSLQLEVLH
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.06| 24| 24| 1363| 1386| 4
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1362- 1385 (39.65/21.42) KMLFFL..QLTQKTSVPPQEPVSIIV
1386- 1411 (34.41/17.50) PIIYDMasGTTQQADIPRQQNSSVAA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 104.27| 32| 32| 66| 97| 5
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66- 97 (51.36/35.22) LMVLTDLLPRKSDVERKIEIVQFASRTRQLFV
99- 130 (52.92/36.52) LLALVKWANNAGKVEKCAMISSFLDQQAILFV
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 155.09| 51| 504| 329| 379| 6
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329- 379 (92.74/64.37) YHAGKCLSLSV.WN...QQ......VLGRKTGTASVHKVTI.KIDE..N...DVSKPLQIFHDPPLP
812- 878 (62.35/40.61) YGTTKGSSISIqWNsihQKfhislgTVGPNSGCSNCHNTILhQLQEmfNktpNVVQLLQVLFDTQAP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.49| 14| 27| 168| 181| 7
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168- 181 (26.30/13.51) RLPTCIRDKII....PPD
194- 211 (19.19/ 7.76) QLNQILRHRLVttdlPPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.60| 14| 37| 1247| 1261| 9
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1247- 1261 (21.47/16.52) LKCRVALSP.KTNqTL
1285- 1299 (22.14/11.63) FETRVAGPPfKAN.TL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 86.45| 28| 32| 509| 540| 16
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509- 540 (41.38/31.41) IKHLPT..LTSETLQLSNYSTHpignLSKNKLFI
542- 571 (45.07/24.20) LTRLPQyyIVVEMLEVPNKPTQ....LSYKYYFM
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