<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30865

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVSGQETDWRSAAFRQKLVSQIEDAMKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQTQLQLQQVALQQQQQQFQQQQVALQQQQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQHLIKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQQQQALQAQPPLQQPPMQQPQPPPSQTLPQQLQPMHHPQHHQPPQPQQPPVAQNQPSQLQAQSQTQPLVSQAPALPGQMLYAQPQLKLVRAPMVVQQPQVQQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length747
PositionTail
OrganismFelis catus (Cat) (Felis silvestris catus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Feliformia> Felidae> Felinae> Felis.
Aromaticity0.03
Grand average of hydropathy-0.719
Instability index88.39
Isoelectric point9.32
Molecular weight82395.46
Publications
PubMed=17975172

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30865
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     364.05|      64|      65|     153|     217|       1
---------------------------------------------------------------------------
  135-  189 (83.84/16.25)	.........MAPHGMAVVSTAAP.........QTQ..lQLQQVALQQQ.QQQFQQQQ.VALQQQQQ.QQQQQQQQQQQ
  190-  256 (91.81/20.85)	QQFQAqQNAMQQQFQAVVQQQQQQL.......QQQ..qQQHLIKLHHQnQQQIQQQQ..QLQRMAQlQLQQQQQQQQQ
  257-  320 (109.97/24.73)	QALQA.QPPLQ...QPPMQQPQPPP.......SQTlpqQLQPMHHPQH.HQPPQPQQ.PPVAQNQP.SQLQAQSQTQP
  321-  387 (78.42/14.64)	LVSQA..PALPGQM..LYAQPQLKLvrapmvvQQP...QVQQV..QQV.QPQVQQQTaVPTAQASQ.IVGSGVQVSQN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      97.74|      19|      19|     397|     415|       2
---------------------------------------------------------------------------
  397-  415 (41.42/14.73)	PGQQVQTPQS.MPPPPQPSP
  417-  436 (29.08/ 7.90)	PGQPSSQPNSnVSSGPAPSP
  556-  570 (27.24/ 6.88)	NDMAVPTP....PPPPVP.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      93.87|      17|      19|      85|     101|       3
---------------------------------------------------------------------------
   85-  100 (22.13/ 7.38)	......QSLTGGPAAGAAGIGM
  101-  120 (21.36/ 6.78)	PsrgpgQSL.GG.MGGLGTMGQ
  121-  134 (23.78/ 8.66)	P.....MPLSGQPPPGTSG...
  441-  456 (26.61/10.86)	P.....SP.SPQPSQSPVTART
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.30|      16|      36|     492|     508|       4
---------------------------------------------------------------------------
  492-  508 (23.61/17.68)	LDKLKQLSKYIePLRRM
  529-  544 (28.69/16.90)	LDILTDPSKRC.PLKTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.14|      17|      45|     614|     634|       5
---------------------------------------------------------------------------
  614-  634 (25.55/30.92)	TAPVVCtrkrRFEDDERQSIP
  662-  678 (30.59/23.13)	TVHLIC....KLDDKDLPSVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30865 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAA
2) QQALQAQPPLQQPPMQQPQPPPSQTLPQQLQPMHHPQHHQPPQPQQPPVAQNQPSQLQAQSQTQPLVSQAPALPGQMLYAQPQLKLVRAPMVVQQPQVQQVQQVQPQVQQQTAVPTAQASQIVGSGVQVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
71
256
147
497










Molecular Recognition Features






MoRF SequenceStartStop




NANANA