<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30858

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDVSTNSNGLSNGKLEKKPPKDQDLPEIPHITANIIPLSNILKFYCQESYKQLTTAVENLSMNVNDESDTKRKKYLLDIIISLRQDFIKIYTLIKWSSISKDVSKFIDLLNWFRLQEFNFEQLIYQLNSLTSYSGAKLPNSDIITSLEVLYHGRPKLPSYNFIQNEKISNEKVLEVLQDLNLVLMTRFALIDIPKKFQKYEVRDGRIYINVPNEFQISLTVGNDLIIDDDSDGSEYYKSPFYLIDFKFLFGINQETLNISFNDEKCSTKLPFNSFKKLEKLSNQILLKEGLQGLYDLLHRYSNSFKLYLIAKNFKDLLINSRWRNNFQINYTTGKSLIIVNYWSLHYLSKNFKSFIELGINHYNSNLSYRWFKNGRYDSDEELDKIFRIQSNSIDQLPSPTSRLNEEENDMVQPDGDEKHEEIPNDDVNVDLILNIVVNKHAELIMGMIFNKLLVKFSNDEVSMITPHQMLLKISPKKSTIFAINPLTGFFYFIDPTPVQNIATKIINSPPSVSNTKPFITELDMVNHIVDEIIKLRLQVFNKEINNKLTTTEWINNGIIKLNDYESTKLSNFFIDITNEDDEQKLDSNDEITKVQFYRRKNWPSSWFLINMVSGLINRSFWWVARIKSINGDWKIQWLEILKFSDDVSVLGVEAEQLDYDFFNRLSTLSSNLIIDHMILEELHSRNVKFIKINPSSTQAKEVFAHKFKIEFPEDPIQDKVEENGSVNTGLHADPLNYESMLLIYNNNELLPIYNSSTVFFLKIHLINNSKMFIKLFGKLRNLNIKNFVSTTDLNLKIDEEKNSFEIFNEIDLISFINTKESKKSLLLFDLIFNTLNKLNELIKILHQLTKNNIAILDNSMDNITIKLNADHPMDLVIKLPEQSNHSIQISTTTPTSTTTKSSWEISLILQFINKYLQEQDEGTTKSNIIGILKYLQDIITPVLQTKQTLIDVISTNTATNNNNNFRLANGLNKLYFDLVFINLNHFQFIYFINSNVSNSKKTQRDKITINVFLKSSSKIPLPTTTSSDGCGDLLMNISLKDNLNPKNVKFKKLFELIFKNINELLPNNNNNNNNGSSSTESSATPAVPVSKSIEDDLINFDIDDDEEEEQKEKEKQEKMKLEMEKKKKREVMIKLNYDYLISLNKLDPVMKSITNGFIQYLQHHID
Length1167
PositionTail
OrganismCandida maltosa (strain Xu316) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.10
Grand average of hydropathy-0.367
Instability index36.15
Isoelectric point5.78
Molecular weight135459.10
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30858
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1378.84|     324|     355|      22|     375|       1
---------------------------------------------------------------------------
   22-  346 (481.98/306.19)	.....................DQDLPEIPHITANiiplsnILKFycQESYKQLTTAVENLSMNVND..ESDTKRK.....K...........YLLD..IIISLRQDFI..KIYT..LIKWSSISKDVSKF..IDLLN..WFRLQEFNFE..QLIYQLNSLTS..YSGAKLP....NSDIITSLEVLYHGRP.KLPSYNFIQNEKISNEKVLEVLQDLNLVLMTRFALIDIPK..KFQK.YE.VRDGRIY.IN......VPNE..................FQISLTVGND...LI...IDDDSDGsEYYKSPFYlidfkflFGINQETLNISFNDEKCSTK..LPFN.SFKKLE...KLSNQI.LLKEGLQGLYDLLHRYSNSFKLYLIAKNFKDLLINSRWRNN..FQINYTTGKSLIIVNYWSLH
  359-  625 (291.85/180.48)	GINHYNSNLSYRWFKngrydsDEELDKIFRIQSN..............SIDQLPSPTSRLNEEENDmvQPDGDEK.....HeeipnddvnvdLILN..IVVNKHAELImgMIFNklLVKFSNDEVSMITP..HQML......LKISPKK..STIFAINPLTGffYFIDPTPvqniATKIINSPPSVSNTKP.......FITELDMVNHIVDEIIK.LRLQVFNK....EINN..KLTT.TEwINNGIIK.LNdyestkLSNF..................F.IDITNEDDeqkL......DSND..EITKVQFY....................................RR...............................................KNWPSS.wFLINMVSG..LINRSFWWVA
  626-  906 (373.43/207.75)	RIKSINGDWKIQWLE.........................ILKF..SDDVSVLGVEAEQLDYDFFN..RLSTLSS.....N...........LIIDhmILEELHSRNV..KFIK..INPSSTQAKEV..F..A...H..KFKI.EFPED..PIQDKVEE................NGSVNTGL....HADPlNYESMLLIYN....NNELLPIYNS.STVFFLKIHLINNSK..MFIK.LF....GKLRnLN......IKN...................F.VSTTDLN....LK...IDEEKNS................FEIFNEIDLISFINTKESKKslLLFDlIFNTLN...KLNELIkILHQLTKNNIAILDNSMDNITIKLNADHPMDLVIKLPEQSNhsIQISTTTPTSTTTKSSWEI.
  907- 1162 (231.57/123.39)	...................................................SLILQFINKYLQEQD..EGTTKSNiigilK...........YLQD..IITPVLQTKQ..TLID..VISTNTATNNNNNFrlANGLNklYFDLVFINLNhfQFIYFINS..N..VSNSKKT....QRDKIT.INVFLKSSS.KIP.....LPTTTSSDGCGDLL..MNISLKDNLN....PKnvKFKKlFE.LIFKNIN.EL......LPNNnnnnnngssstessatpaVPVSKSIEDD...LInfdIDDDEE..EEQKEK...........EKQEKM...........K..LEME.KKKKREvmiKLNYDY.LI..SLNKLDPVMKSITNGFIQYL.......................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30858 with Med14 domain of Kingdom Fungi
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