<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30852

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTEAKASNILTHYYKLAHVGSITYTIYASSENNDQALLELELTIRNKYPEILITYYNKNLYYFAFGHNLINSDSPIDLSTEFHQLSCKSSESVTADQLANPIKNHANNNENLTYAGLSFLKAVKKMILYNLSLNGSIRLFGNYCVSPNDDQSYSILCIDPVLFQNGDLLVSCLEKPNVRLFSSMVAYPEELAIETNFVIYLIPSGIRCHLFDPTNLRNNFIENPQVENEKLPEMLRLTTGIDCDKSKLWVKLIPNLKHLNNQTSFVGKFIHSVDNKKFILWPWDLCLLQFGKYEELQQEELSSASADYSNPMNLISDFLDFQITYNNQVQQQKQTTLEQSLPLPSQQQQQPQNQNQNQNQQQAIHGPFSVGSAQSTGIGSIGHIPDLPKDIGSIGLSATTPMDAELFNLQNTEEFFKTTEHNEIPIDQDQAGERKGTKEEEETDNKSGDDMEIDDLFGGEDSDGDSSNEQKDSAQISGENTGSGNSVSQDNSEQPPKDELDDLFADDSSIALEEKKDSSDDVVELEQLPKPKQEEDISKPKDIKPSYIDILKDQMMLKKSDSSPDYKDPGAPLPIVPTPLVPPTIPQSTGATNPPTVGPGSVTDTIYDGASIYNQSAPPSQMPQQKSVFSPILFNPIIKSDIDTKYGKGGKFYVDKDTASDTDFEKKKRSLRATSVSGMEINFSSEDKKKLQQQLDAIESSTTSESEYGDEEESDEDEEPDMADLTPLKLNESSALPSYQNPATSNIATIGPDFQNADKQFLGNQSMNVEGFGSPFGNQMSKFTMKPESPFMGNEMQTSMSPMYFDISQTQQSPQLQPSAENSEVTKSTMLEAPSKISESSNYLPLLLRNINVSSIPNWYLMNNLTSTKLLPTFSINDDDTESDLDITKSNELIVKLDHLKEFLSFIAPNIVFDLGSNNFGELSYYFNNSAKIESSKELKLPNKSFLESLLKSFPYSYPVKLAEFLHDTKALEFEDQLDNQLNFLNDIPEDENFIDPKALYKKLKSIEWDSFDCNHNNSANFEKYKETVEKLNTGNAPNEEDYFKLPIIKTKVMKNNNIINMNSIGLEFWKYLNFSPIKKTKNFQILLIAETHGNTSSYASELLNQLVQNYRENNFGTITKVNLSTVETRPDLEPINDGLVLINKEQHQSFNDFYVQTNKKLISLVELIKLDLINKTNNFEFDRPLLLLFVNFNKSLNSNLQICKIFRNFKVALMTHQLPLVEIFTKIVPSSLVAKKVGNETSLKILSNYKLTKISMNLYNECPNDVVNRSTVKNIFTTIVKEPPSKIQFRFINNAYRDNSFNDDIFLHLAYERSVDKNWFVASWSDPLGQVVHTKAWYCSNSPAQQHQQQHSSSSQQQTPSHHQQQQQQQHHNQQRQGYRHDTMDIMSISDDIWNISTELFKFLNDEMNSNGGNTFGGKKFLVLTRVNSIIPDDELVHWKRLSQKHKEISLIVLSVCQTPKIVGSSELQDFSSRASNFSPLPTNPEKDSFFNFKTAFSTSNNSSPASGGALVTSPNGLSFHSPQQFLNAPANFLSPQDLMAPSSMGNTPSGTMNNELDSDTILCSLKDDVYGVVSKLPLPSFNSPTRFCMKTGYLMKEVREDFPDDIKEEQDEQATKSKSYLLYEINLLSCSNYWNLDVLMRLLMLQYKKMIVLNDVLCMNSLDGAKEDIELSENYNAIVPWHINAVGKLLNYLVHVYVDEE
Length1703
PositionKinase
OrganismCandida maltosa (strain Xu316) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.549
Instability index45.47
Isoelectric point4.83
Molecular weight192413.19
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30852
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.26|      13|      25|     432|     444|       1
---------------------------------------------------------------------------
  432-  444 (21.52/12.80)	GE.RKGTKEEEETD
  459-  472 (15.97/ 7.26)	GEdSDGDSSNEQKD
  478-  490 (19.78/11.07)	GE.NTGSGNSVSQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.31|      16|      16|    1344|    1359|       2
---------------------------------------------------------------------------
  344-  362 (27.09/12.80)	PSQQQQQpqnQNQNQNQQQ
 1344- 1359 (29.75/14.75)	PAQQHQQ...QHSSSSQQQ
 1361- 1376 (32.47/16.75)	PSHHQQQ...QQQQHHNQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.55|      16|      16|    1192|    1207|       3
---------------------------------------------------------------------------
 1192- 1207 (28.80/16.62)	NFNKSLNSN.LQICKIF
 1209- 1225 (23.75/12.45)	NFKVALMTHqLPLVEIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     188.04|      49|     272|     536|     587|       4
---------------------------------------------------------------------------
  499-  545 (57.75/32.11)	ELDDLFADDssiALEEKKDSSDDV....VELEQLPKP......KQeeDISKPKDIKP
  546-  599 (76.65/55.18)	SYIDILKDQ...MMLKKSDSSPDYkDPGAPLPIVPTPlvPPTIPQstGATNPPTVGP
  601-  636 (53.64/29.21)	SVTDTIYDG...ASI........Y.NQSAP.........PSQMPQqkSVFSPILFNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.04|      21|      46|     209|     231|       5
---------------------------------------------------------------------------
  209-  231 (32.82/22.88)	HLFDPTNLRNNFIENpqVENEKL
  258-  278 (36.22/18.66)	HLNNQTSFVGKFIHS..VDNKKF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     231.72|      47|      47|     979|    1025|       6
---------------------------------------------------------------------------
  897-  936 (54.89/26.14)	........LDHLKEFLSFIAPNIVF.DLGS...NNFGELSYY.....FNNSA.KIESS
  942-  977 (38.39/16.04)	P..NK.SFLESL...............LKS...FPY.SYPVKlaeflHDTKAlEFEDQ
  979- 1025 (83.03/43.36)	D..NQLNFLNDIPEDENFIDPKALYKKLKS...IEWDSFDCN.....HNNSA.NFEKY
 1027- 1072 (55.42/26.46)	EtvEKLNTGNAPNEEDYFKLPIIKTKVMKNnniINMNSIGLE............FWKY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.74|      32|      37|    1103|    1137|       7
---------------------------------------------------------------------------
 1103- 1137 (46.03/36.40)	LLNQlVQNYRENNFGTITKVNL.STVE.TRPDLepIN
 1142- 1175 (43.71/24.19)	LINK.EQHQSFNDFYVQTNKKLiSLVElIKLDL..IN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.63|      25|      29|     762|     790|       8
---------------------------------------------------------------------------
  763-  790 (40.99/26.08)	GNQsmnVEGFGSPFGNQMSKFTMKPE.SP
  793-  818 (40.64/22.53)	GNE...MQTSMSPMYFDISQTQQSPQlQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.71|      10|      41|       5|      14|       9
---------------------------------------------------------------------------
    5-   14 (19.05/12.46)	KASNILTHYY
   47-   56 (19.67/13.13)	KYPEILITYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.00|      22|    1047|     381|     428|      10
---------------------------------------------------------------------------
  381-  413 (28.63/52.67)	IGHIPDlpkDIGSIGlsattpmdAELFNLQNTE
 1387- 1408 (41.37/13.52)	IMSISD...DIWNIS........TELFKFLNDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.10|      23|      43|     137|     160|      11
---------------------------------------------------------------------------
  137-  160 (39.66/31.72)	IRLFGNYCVSPND...DQSYSILCIdP
  178-  203 (35.44/22.40)	VRLFSSMVAYPEElaiETNFVIYLI.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.63|      29|      29|     694|     722|      12
---------------------------------------------------------------------------
  694-  722 (47.37/27.73)	QLDAIESSTTSE.SEYGDEEESD.EDEEPDM
  724-  754 (40.26/22.33)	DLTPLKLNESSAlPSYQNPATSNiATIGPDF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30852 with Med13 domain of Kingdom Fungi
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