<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30845

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMEIGSIEGPVGGMPDTSIMDPTMDDLFGEATGDLVTAMPTPPVPAALLVRLADMQSRGCCRKLAWSNTGSIAYIARDGSQVTFRAMVRHPKTGAWTASEPSKHAIQAPEGRVFVHLQFNGIGIELAVVDDAGVVHMYTLTGALSRMVPAAGGDLSRKTDEHSMNAIVGLHWLALFPAEFRGPYLDVARKNGDKWEAPIKHRDQHALKAHHPAEGRHALLHISRSTELTLLYQNEGQGWQSTSVVLHTVRSSDEYLTHAALGEDGADLLAVTADQSSQLRLYRITIHWNATQQSRGSQQHTLVSPELDVHHLTAVEMVRAQQMDGAKLSQLDIIPAVPEAAQLSPTTPTVQAIFTYSAASLDSSQNQAYSSTVLRWTVESYSPTLHESFKKLRQGSGDANNHVLHQATLLKRQADTTIPKIIMAFASQAFDTISAFATSDGCLDFRDRVSMNTLSSFNDTEIVSNIPQTGFWHPSGAQNVHVAMSSDGSALALVRANGEIATQNMIFTHGWQETEDALVGDNRAYIEAATVCIARQYAFLCFNNVSNDEVLALLPVNASVEIRSRVVKMIFRMLQRTPDISCQDQSRQQMIVLKEPFVPRCLSAQLALGTNSVTGERNFSAQYAFAMLTLRLASTACAQTLSRQDMKSISSDAVHSLRGLVKWCIDLMVYVVRTLVEVKRNLESGVTAKQAFEVLVTSSGSIALHLALCSYSRVVLRFQTMWIVKYMQAVQLVLGRARSIAEQQELTAILKHIKAMPFKLPHFEQMLAELDVAIRGAYNQPSISVEQRGQLETDMIVDGTVPSELEQPLNSLLDSMVPRLTAHVNLSDLMFWDVTLTHLRNCRRAEDGRAYDVIRKIVLPKHMQRRVCRRCGSYMEDVNADRLRGGDTVAWFAHLQRHCLCMDYWLLA
Length907
PositionTail
OrganismSphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Sphaerulina.
Aromaticity0.07
Grand average of hydropathy-0.106
Instability index42.46
Isoelectric point6.49
Molecular weight100365.54
Publications
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30845
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.28|      15|     120|     167|     186|       1
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  170-  186 (27.01/28.81)	HWLAlfPAEFRG........PYLDV
  286-  308 (23.26/ 8.36)	HWNA..TQQSRGsqqhtlvsPELDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     287.28|      94|     260|     320|     429|       4
---------------------------------------------------------------------------
  320-  429 (147.83/133.04)	QQMdgaklsqldiI....PAVPE..AAQLSPTTPTVQAIFTYSA....ASLD.SSQNQAYSSTVLRWTVESYSPTLHESFKKLRQGSGDANNHVLHQATLLKRQADTTIPkiimafASQAF
  587-  691 (139.46/95.18)	QQM..........IvlkePFVPRclSAQLALGTNSVTGERNFSAqyafAMLTlRLASTACAQTLSRQDMKSISSDAVHSLRGLVKWCIDLMVYVVRTLVEVKRNLESGVT......AKQAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.86|      44|     269|     210|     258|       7
---------------------------------------------------------------------------
  210-  258 (65.30/65.59)	HPAEGRHalLHISRSTE...LTLLYQNeGQ..........GWQSTSVVLhtVRSSDEYLTHA
  472-  528 (64.55/45.85)	HPSGAQN..VHVAMSSDgsaLALVRAN.GEiatqnmifthGWQETEDAL..VGDNRAYIEAA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30845 with Med16 domain of Kingdom Fungi
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