<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30840

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGRLIMDQQGPVGSQDLKKDRGQAHEGVTSQKRDFAQMQGTAHANGSANGHPNGQSLANGVNGQHQLSTATSGHSNGTPTAVSSLPTPPPLDQSWRSSDANKPMGVMLQRLAQQCFADLNDTCNKMSQMPPPPPAAANGVVPHINDPSRESVERKRVWMDFANGQRDRFIKALVLSDWARSEHDMAKLVDLKVWQEKQSRAQDAAKRFIGEIKHGVVAAKMRNPNIEDAMELLATGKSSKWPDLMWIPPKKLPAKRLVATLNDMNVMLATRLNLHEELPLHFRDYSIANGRATFRVPGEFEVDLSIAEEDPSSQFYLIDLRFTFTPTPSISDPLRNALEAQTNGALSSKGLQGCYEFLHNFVLTHKINVFRSQAVKLFREKWFGCLVTETQRRVFAIHYWRDQAGKKSWIEFGINTGKVQGKRMRKAPTARHSVRWFRHGQEVQDDSIEIDWNNLDLDAILTQVIAKHASWTLSTVEKRLRTYAGTASTLHSELCTSASNPGACKLGLSLPGLRTAITLRLEPVTGLMTIFPESRDAATAERNFNRNPIVDNSASFTQLLCRAVQDRVRRAVISSGWQLADLRGFGAQPNFKALFGQGIVRSDILHCARGWKDWALCTTYSLSGQNWWAVRLNKQAVEQGKTVTTIAEARAINVSATGLCRADLSRIRRLAEAEISFAVLAHDLEANQIPHHIDSLSSPQLHSDTTSLQQDSAVAVYLRLTPKDLKSSVLTKYKSLSITNWVRIAYQGIVDEDEETAHVRHDIRLTVDSEKLKHLHDYFTNSKVRDADIAMNGSGGLALSLRTPLGQPYVTKIIALLDRCRELNEVLLTAPRLQFTCTTVGLQKITFTYGAMHQYIGSLVTNGSGTLLKLDPPFTNPHQRIRVLLERLYNKARDHKFWALALAMNAVQPLLESLVNLETSHAAQHTLLIHSHDVSMHTVEYRSPFIPCRFKASVQWYRAEGGRRQHRYTITPHQREGVEMPAAFSNALDELSRNCGSTAEGWFGNNKGGYTATHPKGLPTVFRRLDDFMRTSGQASDATVNKVEKQETPVPNAKPTLNRNPSKHNVSHQQKPNGQTQPKPQPRPQQQNQSKQSYKPHDSTANQTLKPNQKSGKTKQEQEVIELD
Length1125
PositionTail
OrganismSphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Sphaerulina.
Aromaticity0.07
Grand average of hydropathy-0.519
Instability index39.94
Isoelectric point9.45
Molecular weight125722.05
Publications
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30840
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.07|      15|      16|      11|      26|       1
---------------------------------------------------------------------------
   11-   26 (23.89/18.15)	GpVGSQ..DLKKDRGQAH
   28-   44 (24.17/12.65)	G.VTSQkrDFAQMQGTAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     154.04|      38|      39|     960|     997|       2
---------------------------------------------------------------------------
  925-  959 (27.65/13.77)	........QHTLLIHSHdvSMHTVEyrspfIPCRFKASV.QWYR...
  960-  997 (71.12/48.07)	AEG..GRRQHRYTITPH..QREGVE.....MPAAFSNALDELSRNCG
 1000- 1034 (55.27/35.56)	AEGwfGNNKGGYTAT.H..PK.G.......LPTVFRR.LDDFMRTSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.06|      23|     111|     619|     651|       3
---------------------------------------------------------------------------
  619-  643 (38.23/40.30)	TTY.SLSGQNWwaVRLNKQAV..EQGKT
  732-  757 (33.83/13.41)	TKYkSLSITNW..VRIAYQGIvdEDEET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.97|      32|      42|      59|      91|       5
---------------------------------------------------------------------------
   59-   91 (55.67/36.16)	AN...GVNGQhQLSTATSGHSNGTPTAVSSLPTPPP
  101-  135 (57.30/32.51)	ANkpmGVMLQ.RLAQQCFADLNDTCNKMSQMPPPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.83|      32|      36|    1047|    1078|       6
---------------------------------------------------------------------------
 1047- 1078 (57.30/32.65)	QETPVPNAKPTLNRNPSKHNVSHQQKPN...GQTQ
 1082- 1116 (51.53/28.62)	QPRPQQQNQSKQSYKPHDSTANQTLKPNqksGKTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.85|      40|     112|     763|     802|       7
---------------------------------------------------------------------------
  763-  802 (65.46/45.96)	DIRLTVDSEKLKHLHDYFTNSKVRD..AD.....IAMNGSGGLALSL
  833-  871 (53.79/36.30)	RLQFTCTTVGLQKI..TFTYGAMHQyiGS.....LVTNGSGTL.LKL
  872-  915 (57.59/39.45)	DPPFTNPHQRIRVLLERLYN.KARD..HKfwalaLAMNAVQPLLESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.15|      17|      36|     153|     170|       8
---------------------------------------------------------------------------
  153-  170 (28.33/24.99)	VERKrVWMDFANGQRD...RF
  190-  209 (25.83/16.54)	VDLK.VWQEKQSRAQDaakRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.35|      10|      21|     280|     289|       9
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  280-  289 (20.53/11.67)	PLHFR.DYSIA
  298-  308 (14.82/ 6.57)	PGEFEvDLSIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.34|      34|      38|     543|     580|      13
---------------------------------------------------------------------------
  543-  580 (51.75/45.01)	RNFNRNPivDNSASFTQLLCRAvqDRVRRAVISSGWQL
  584-  617 (64.60/42.52)	RGFGAQP..NFKALFGQGIVRS..DILHCARGWKDWAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30840 with Med14 domain of Kingdom Fungi
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