<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30834

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMQNYDTHVLQWSQPQVAGRLTQITSIPPYTELDSKGRPKFTDEQILAQVSELSVVNSRAGFFVWLSAALSARPLTDDMTILSYLQGRYPNDMQLLVVDLLVASFDVLTNSLLTKAKPQYHRVIRSFIVNKVPILITRVQANMQAAVTTEACIQMAMMPGGLITVNPLPPMTADSNAVGDYLKGTRLDFLQACALHGLVTEGAISAILQESVALSRIQKLNKDSLVGQCTSNISKIGELFEDLSGMQGNAGAIASCIVETIGNLCLSKDTISLKSVCDRLVKRIPLMDYIMLFAQPGVLLLPVCNLLNNWVHDQDQTEFTPAYEEFASVLLFALSVIHRYNLKFTDIGVQGDSFIAKLLDDMTVSKPTTELSAEQGSQLGKWLEGLFTVDEHGEPSGISDEVMRQCPPQSFYQLVPTLLEQSILACKASALKMKTFKGGLELLLEPFLLPSLIMGLGWLAGHSWEDHNDADVLLQVLEKLLRHSSSSQETQAMHRAVLAIVADSLHSSLEEFSKKQPSKKQVTELLKLLGPYVNEQRTFRCTQAEIDLIINQGGMKNLIRQTVRDVINWGATQSNPPNPPPRYAHRFFVAACQTLDDQEILKTLVEEVLQSGPANMSIALDLCTGLICAPTAGPLSMQSPSAAASSAAKLRDCVRLTNSNVQGLLERPVSEAEVLVRLGRRVEAQLAFAAQMPPMALPLQIPEQAADQMLQDLLDGNTASATNDGALNQNTDMSGLEQQIDMTSINNATADDLLKMASGPGAMDVDSNQMFIELGMNTDDKQQNQQGDLQNQEEDIFAGLDMGMGDMGDDLDFNFG
Length815
PositionTail
OrganismPseudocercospora fijiensis (strain CIRAD86) (Black leaf streak disease fungus) (Mycosphaerella fijiensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Pseudocercospora.
Aromaticity0.06
Grand average of hydropathy-0.047
Instability index44.28
Isoelectric point4.72
Molecular weight89132.12
Publications
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30834
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     326.91|      94|     294|     342|     440|       1
---------------------------------------------------------------------------
  214-  252 (35.83/12.86)	..........SRIQKLNKDSLVGQCTSNI.....SKIGELFEDLSGM..QGNAGAI............................................
  342-  440 (151.36/89.50)	KFTDIGVQGDSFIAKLLDDMTVSKPTTELsAEQGSQLGKWLEGLFTVDEHGEPSGISdevmRQCPPQSFYQLVPTLLE.QSILACKASALKMKTFKGGLE
  648-  736 (139.73/72.24)	KLRDCVRLTNSNVQGLLE.....RPVSE..AEVLVRLGRRVEAQLAFAAQMPPMALP....LQIPEQAADQMLQDLLDgNTASATNDGALNQNTDMSGLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.52|      26|     145|     592|     617|       2
---------------------------------------------------------------------------
  592-  617 (42.82/27.54)	QTLDDQEILKTLVEEVLQ..SGPANMSI
  737-  764 (39.70/25.01)	QQIDMTSINNATADDLLKmaSGPGAMDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.12|      16|     140|      18|      34|       3
---------------------------------------------------------------------------
   18-   34 (25.64/16.30)	GRLTQITSIPPYTElDS
  159-  174 (30.47/15.53)	GGLITVNPLPPMTA.DS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.88|      13|      25|     767|     779|       5
---------------------------------------------------------------------------
  767-  779 (23.97/14.74)	NQMFIELGMNTDD
  793-  805 (23.91/14.68)	EDIFAGLDMGMGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30834 with Med5 domain of Kingdom Fungi
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