Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MYAQFQASYQRVEASLQKLTDSIAAYNPSVSAADELVAADEAVKQNLDELVKHQQNYLRLQELRQTSNSLDETIKTTIRLLADTRKDIASIPATDSSADRRDVDIQELLTYAKYIAPTTVPPTYRKSPKDDSQSHSNVVESTAGSAGHTTQISNGLSTPPPQATTTAEDHNPAFIKSENIGLTTMEERDKAWLLPDPDVFQPWPTQDVMNSGALGDIQRMIERGEDPSTKLSKQEQAEADLKREAEEEANRQRKAEEERRAKEMFGAGTMQRRGTIVEAFNPDDL |
Length | 285 |
Position | Middle |
Organism | Sphaerulina musiva (strain SO2202) (Poplar stem canker fungus) (Septoria musiva) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Sphaerulina. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.820 |
Instability index | 46.79 |
Isoelectric point | 4.80 |
Molecular weight | 31737.65 |
Publications | PubMed=23236275 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP30833 No repeats found |
MoRF Sequence | Start | Stop |
1) RDKAWLL 2) RRAKEMFG 3) RRDVDIQELLTYAKYIAPTTVPPTY | 188 259 100 | 194 266 124 |
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