<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30819

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGILIMNHTASDAATASRHGDSNTAAPNGASAAATALDKYSQLPPEIAHIGPEQYNALSTLLLRLSQESYNDLTSILQKMAALPVAPMANGALPNGLGAASMQGNAESNKRKKLMLLQFAQEQRSKFIKLLVLAEWGKKAASDISKLIDIFSWAGAHARNMDAADDQLERIKMLSNIARENNPDIATALQVLSTGTASWMPSLDYIPPKPISSDEALKLLTYMNTSLSIRLNVHENLPRHLRNWRIHSGRVTFAIKGQLEFDVMSFVEDASQQWFLIDLRLLFTPAPTVTVGSRFFMQLKQQADFVLKHKGLPGLFDFLNNFMLTHKISVLRSQATALVRAGWAGSLKVEPVHRLLVVQYWTNKPGKKNWIEIGVSNNRLSNAKSSWRGPPIPSLSTRWFRQGKEVKDANFAFDWTNLSMEKVIKLVIARHTSDILRSTKESIKSGVLAETDLSEAEPADCRLNATLGTKSASITLSLEPVTGNHIIRPASALSARAENAFNLGREPAQMAHVMTQVLAGTLLGLIQRNAQQLGWQAVARQSLTPQMVKAAVKLDVISSVLYWPHAWSPSWAFAAIIDSSGESWWVLEIGSTGNSIEHAEQIRMNRPDKSPLPINRSTLASLERVAVQLLSFRVTARQLDKEKKMYALEEELGQTPASAQGRRIARRWVLRVQTSDLLASSTRHDKWLEPDIKITCEGLRVGGPNVWHVASGKMVKSVAADMHKLMAASPQKAFKFSDDGNFRILLSTPFGQDLLGELRARLRDVDRLRSFATTLQKRRMRLASSSLQRVQFLYGPSPYTATVNFSSEKEVTIELSSKNPHHRILNLLTHIANDRLPSFMSLDANDANGLDRFCTTLVLTRPLFKVFREIEQRSPGNYRNPAIHVHSILKYRITYENPVCTFDVRLQPKEDQVFWFVEDNLRPKDPNVLPTPERGQGHRRLDSLQEKLKELFSSKGPGWFGTRNGMVVELDAIPDALRKLDECVLSCRMEGGYVAPPPLERPVQQAQNPGQGMPKTNGMQQGNQQQQQARMQQQQQQQQQHQARQQQQGQQQMRMQQSNQRVQQPNGRQPQHMQNARQHMQHQQGRGGRPGQTQNNVIEID
Length1102
PositionTail
OrganismCochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern corn leaf blight fungus) (Bipolaris maydis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.07
Grand average of hydropathy-0.432
Instability index48.00
Isoelectric point9.79
Molecular weight123442.65
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30819
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     122.82|      19|      19|    1039|    1057|       1
---------------------------------------------------------------------------
 1018- 1033 (31.26/11.84)	NGMQQGNQQ...QQQARMQ
 1039- 1057 (37.89/15.66)	QQQHQARQQQQGQQQMRMQ
 1063- 1080 (31.85/12.18)	VQQPNGRQPQH.MQNARQH
 1081- 1095 (21.81/ 6.39)	MQHQQGRGGRPGQTQ....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.53|      14|      19|     293|     311|       4
---------------------------------------------------------------------------
  293-  311 (17.08/24.41)	GsrFFMQLKqqaDFVLKHK
  315-  328 (27.45/16.99)	G..LFDFLN...NFMLTHK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.87|      46|      66|     726|     772|       5
---------------------------------------------------------------------------
  726-  772 (74.44/61.72)	LMAASP.QKAFKFSDDGNFRILLSTPFGQDLLGELRARLRDvDRLRSF
  794-  840 (75.43/57.41)	LYGPSPyTATVNFSSEKEVTIELSSKNPHHRILNLLTHIAN.DRLPSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.83|      11|      64|      24|      34|       6
---------------------------------------------------------------------------
   24-   34 (20.56/11.08)	NTAAPNGASAA
   91-  101 (21.27/11.71)	NGALPNGLGAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.53|      12|      21|     551|     568|       8
---------------------------------------------------------------------------
  551-  568 (10.44/23.11)	AAVkLDviSSVLYWphaW
  575-  586 (25.09/13.77)	AAI.ID..SSGESW...W
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30819 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGYVAPPPLERPVQQAQNPGQGMPKTNGMQQGNQQQQQARMQQQQQQQQQHQARQQQQGQQQMRMQQSNQRVQQPNGRQPQHMQNARQHMQHQQGRGGRPGQTQNNVIEID
992
1102










Molecular Recognition Features






MoRF SequenceStartStop




NANANA