<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30811

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCTTNAQAIGDFEAIAYQAISVTRTANTTTTSTTSPQSSKQPPPSSSPSEDTRAVEAELRHALHLVAHDAARPWLWLFKPTTVDKLGQASPQLPELGGYRLQREHTGAIKAIDLVRPPMRPGAPHPAATSNHPPSTNAPQRGLQSGNNPRPAQGSTQPQPSADPPPPPDCFTLYELFTSSVVALISFHVVKDCQVVALNYRTFVSKASKCIADAQTEVDPQPEVHRLTSINVHWASSGTLLLSTFTDRKNTIRCLTSVSTQTEERQLVGTCIRVAPNGVLATIMSFEDPLDSINEEISIRHRKRTKLTSLEQNIEKWKSSVKRWLGWKGYDLPDLDQRTSWVRIRTTLMSSPILSSPASVGPERDTLWPRALCFFHVVDEPDLTITGTNTIGAAGNSNILRWFETPESMGFKDPLDVAQEWFLGKPDRDKILEARKKAKKAEEDAVRRKEEHPGLHPSSPLNARGGTYGDLQAVSGVYPTPPDGIAPGTGVSYSDTPTVSGTASNVVLVAGGSNPAINLSAPPDSAKTEDQQMITTSPAVPSATDNFNTSSGNDDLFEDMEEDGYTGDRINDTDFDFFDGPDNDDVDMLDAPALPNDNAPPTHATQDLHPKAATEPQAQDDMSDPFAALENALGTASEPAMSQDLAKGKEPAHMPAPKIEISDNAGDNQSSPVRRKVSFSRAPTPPLSPSKILKALEPSPPRKSASRTRSERGSESHPDAHFTPVVFNRKMSLSDAKYQGGRFSAHRPTTPTGQVQLSPSPARNTAATQPKSLREFPLLSKLRLAAGIASANRIPEIASLARAASDDSDSSSEASDASGNDSGDEEVEVTPAAIMNSLSMPAKRKLQSEGNATPLSVTSFAESLGGDWLDLYGLHLDEVNLSSFEPSLWDWSLVNVPSPAERPVAGARYSLPTLLPGPAQMPDTPTSQPDPAYEVPDEKPLSAKDSISITQIVTDQLVSTTLDMLSEDPPIRSEFNNDAVAETPWYKVIKNLFPTATDCDLPTLAGVNEVFQDYAALAKAQQRPPARKSDSPAVTGSHMYQIQAPFLRVRRAETHWDLLPPAVAFWETLGLSPISHPKNIVTFCVYPHSDAIRPCLESFLLNLQLAYDGCKLGNHSRVETAVEYEGGLVPVRATSTIAPRETFKLLKDTCVQLGKLLALQYGQIREQQDSKVDAFVIYIIDPFGGSSAVWELCSAFWALFQAYTQGHPGRPDQPQKPDVVLQIIPMKYVASFDAPVILDPSTYMGLAREVYDRCPPSAPSGDKTSLSIYKAPAFHLEETLPRNIPFKLISEPAQDLLRENTYMHLGYAISLDGAWVTAAWTDSCGKSQAVVSYYLGTRMFREIAKEIWQTTIEILQSRRVNWRVCIAKAGVLEREELETWVFLISCPTQINVFVTLLTAVDTDPPYQFTPTVPNPTPATGAGATTPGSTPQAGVSPSDPGPGLTPAATPAADPTATDPAADPEARLIDVTDDTWGIILAHRLHNSHTTTQFSPALISGLLVKRGETLQTSNSIAHPIPDPEQGPIVIAVNFLWIGAVGSSRNATTNLPFPSSTSSSANAPASSISSSDLPSPGGSNLPNPYANNPGTPQSPGPGQEGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGTRNGTIPWHVAAAKRGVEGLSKISGGAGTAV
Length1677
PositionKinase
OrganismCochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern corn leaf blight fungus) (Bipolaris maydis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.384
Instability index49.20
Isoelectric point5.35
Molecular weight180908.77
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30811
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.82|      74|     123|     259|     334|       1
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  259-  334 (120.05/84.60)	CLTSVsTQTEERQLVGT.CIRVAPN.GVL.....ATIMSFEDPLDsINEEISIRHRKRTKLTSLEQNIEKWKS.SVKRWLGWKG
  378-  459 (109.77/68.96)	CFFHV.VDEPDLTITGTnTIGAAGNsNILrwfetPESMGFKDPLD.VAQEWFLGKPDRDKILEARKKAKKAEEdAVRRKEEHPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     546.24|     127|     132|    1379|    1509|       2
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  123-  174 (39.63/ 8.55)	......................................PMRPG...aPHPA..ATSNHPPSTnaPQRGLqSGNN........P...RPA.QGSTQP...QP.SA.DPPPPPD..............................................
  597-  649 (34.37/ 6.24)	......................................PALPNdnapPTHATQDLHPKAATE..PQAQD.DMSD........P...FAALENALG.......TASEPAMSQD..............................................
  656-  729 (50.60/13.39)	..........................................................PAHM..PAPKI.EISDnagdnqssPvrrKVSFSRAPTP.PLSP.SKILKALEPSPPRKSASRTR.....SERGSES....HPDAHFTP............
  749-  798 (38.73/ 8.16)	.......................................................SAHRPTT..PTGQV.QLS.........P...S........P.ARNT.AATQPKSLREFPLLSKLRLAAGIASANR............................
 1379- 1509 (213.04/92.71)	REelETWVFLISCPTQ..INVFVTLLTAVDTDPPYQFTPTVPN....PTPATGAGATTPGST..PQAGV.SPSD........P...GPGLTPAATP.AADP.TATDPAADPEARLIDVTDDTWGIILAHRLHNS....HTTTQFSPALisGLLVK.RG
 1514- 1643 (169.86/66.63)	TS..NSIAHPIPDPEQgpIVIAVNFLWIGAVGSSRNATTNLPF....PS.STSSSANAPAS......SI.SSSD.......lP...SPGGSNLPNPyANNPgTPQSPGPGQEGQR.STTSLMWTPTPQTRTTAEgllkEVLGQFR.AL..GLLAKlRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     264.50|      67|     123|     799|     865|       3
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  799-  865 (107.33/54.48)	IPEIASLARAASDDSDSSSEASDA...SGNDSGDEEVEVTPAAIMNSLSM.....PAKRKLQSEGNATPLSVTSF
  920-  990 (93.15/46.26)	LPGPAQMPDTPTSQPDPAYEVPDEkplSAKDSISITQIVTDQLVSTTLDMlsedpP....IRSEFNNDAVAETPW
  991- 1036 (64.02/29.37)	YKVIKNLFPTAT.DCDLPTLA...........GVNEVFQDYAALAKAQQR.....PPARKSDS............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.93|      19|     128|    1061|    1082|       7
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 1061- 1082 (32.19/25.65)	WDLlppAVAFWETLGLSPISHP
 1195- 1213 (39.74/22.29)	WEL...CSAFWALFQAYTQGHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.23|      21|      24|     461|     481|       8
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  461-  481 (40.05/19.82)	HPSSPLNARGGT...YGDLQAVSG
  483-  506 (37.18/17.83)	YPTPPDGIAPGTgvsYSDTPTVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.09|      15|      27|     549|     565|       9
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  549-  565 (24.48/23.85)	TD.NFNTSSGNDDLfeDM
  578-  593 (26.60/17.28)	TDfDFFDGPDNDDV..DM
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30811 with Med13 domain of Kingdom Fungi
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