<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30811

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCTTNAQAIGDFEAIAYQAISVTRTANTTTTSTTSPQSSKQPPPSSSPSEDTRAVEAELRHALHLVAHDAARPWLWLFKPTTVDKLGQASPQLPELGGYRLQREHTGAIKAIDLVRPPMRPGAPHPAATSNHPPSTNAPQRGLQSGNNPRPAQGSTQPQPSADPPPPPDCFTLYELFTSSVVALISFHVVKDCQVVALNYRTFVSKASKCIADAQTEVDPQPEVHRLTSINVHWASSGTLLLSTFTDRKNTIRCLTSVSTQTEERQLVGTCIRVAPNGVLATIMSFEDPLDSINEEISIRHRKRTKLTSLEQNIEKWKSSVKRWLGWKGYDLPDLDQRTSWVRIRTTLMSSPILSSPASVGPERDTLWPRALCFFHVVDEPDLTITGTNTIGAAGNSNILRWFETPESMGFKDPLDVAQEWFLGKPDRDKILEARKKAKKAEEDAVRRKEEHPGLHPSSPLNARGGTYGDLQAVSGVYPTPPDGIAPGTGVSYSDTPTVSGTASNVVLVAGGSNPAINLSAPPDSAKTEDQQMITTSPAVPSATDNFNTSSGNDDLFEDMEEDGYTGDRINDTDFDFFDGPDNDDVDMLDAPALPNDNAPPTHATQDLHPKAATEPQAQDDMSDPFAALENALGTASEPAMSQDLAKGKEPAHMPAPKIEISDNAGDNQSSPVRRKVSFSRAPTPPLSPSKILKALEPSPPRKSASRTRSERGSESHPDAHFTPVVFNRKMSLSDAKYQGGRFSAHRPTTPTGQVQLSPSPARNTAATQPKSLREFPLLSKLRLAAGIASANRIPEIASLARAASDDSDSSSEASDASGNDSGDEEVEVTPAAIMNSLSMPAKRKLQSEGNATPLSVTSFAESLGGDWLDLYGLHLDEVNLSSFEPSLWDWSLVNVPSPAERPVAGARYSLPTLLPGPAQMPDTPTSQPDPAYEVPDEKPLSAKDSISITQIVTDQLVSTTLDMLSEDPPIRSEFNNDAVAETPWYKVIKNLFPTATDCDLPTLAGVNEVFQDYAALAKAQQRPPARKSDSPAVTGSHMYQIQAPFLRVRRAETHWDLLPPAVAFWETLGLSPISHPKNIVTFCVYPHSDAIRPCLESFLLNLQLAYDGCKLGNHSRVETAVEYEGGLVPVRATSTIAPRETFKLLKDTCVQLGKLLALQYGQIREQQDSKVDAFVIYIIDPFGGSSAVWELCSAFWALFQAYTQGHPGRPDQPQKPDVVLQIIPMKYVASFDAPVILDPSTYMGLAREVYDRCPPSAPSGDKTSLSIYKAPAFHLEETLPRNIPFKLISEPAQDLLRENTYMHLGYAISLDGAWVTAAWTDSCGKSQAVVSYYLGTRMFREIAKEIWQTTIEILQSRRVNWRVCIAKAGVLEREELETWVFLISCPTQINVFVTLLTAVDTDPPYQFTPTVPNPTPATGAGATTPGSTPQAGVSPSDPGPGLTPAATPAADPTATDPAADPEARLIDVTDDTWGIILAHRLHNSHTTTQFSPALISGLLVKRGETLQTSNSIAHPIPDPEQGPIVIAVNFLWIGAVGSSRNATTNLPFPSSTSSSANAPASSISSSDLPSPGGSNLPNPYANNPGTPQSPGPGQEGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGTRNGTIPWHVAAAKRGVEGLSKISGGAGTAV
Length1677
PositionKinase
OrganismCochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern corn leaf blight fungus) (Bipolaris maydis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.384
Instability index49.20
Isoelectric point5.35
Molecular weight180908.77
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30811
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     229.82|      74|     123|     259|     334|       1
---------------------------------------------------------------------------
  259-  334 (120.05/84.60)	CLTSVsTQTEERQLVGT.CIRVAPN.GVL.....ATIMSFEDPLDsINEEISIRHRKRTKLTSLEQNIEKWKS.SVKRWLGWKG
  378-  459 (109.77/68.96)	CFFHV.VDEPDLTITGTnTIGAAGNsNILrwfetPESMGFKDPLD.VAQEWFLGKPDRDKILEARKKAKKAEEdAVRRKEEHPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     546.24|     127|     132|    1379|    1509|       2
---------------------------------------------------------------------------
  123-  174 (39.63/ 8.55)	......................................PMRPG...aPHPA..ATSNHPPSTnaPQRGLqSGNN........P...RPA.QGSTQP...QP.SA.DPPPPPD..............................................
  597-  649 (34.37/ 6.24)	......................................PALPNdnapPTHATQDLHPKAATE..PQAQD.DMSD........P...FAALENALG.......TASEPAMSQD..............................................
  656-  729 (50.60/13.39)	..........................................................PAHM..PAPKI.EISDnagdnqssPvrrKVSFSRAPTP.PLSP.SKILKALEPSPPRKSASRTR.....SERGSES....HPDAHFTP............
  749-  798 (38.73/ 8.16)	.......................................................SAHRPTT..PTGQV.QLS.........P...S........P.ARNT.AATQPKSLREFPLLSKLRLAAGIASANR............................
 1379- 1509 (213.04/92.71)	REelETWVFLISCPTQ..INVFVTLLTAVDTDPPYQFTPTVPN....PTPATGAGATTPGST..PQAGV.SPSD........P...GPGLTPAATP.AADP.TATDPAADPEARLIDVTDDTWGIILAHRLHNS....HTTTQFSPALisGLLVK.RG
 1514- 1643 (169.86/66.63)	TS..NSIAHPIPDPEQgpIVIAVNFLWIGAVGSSRNATTNLPF....PS.STSSSANAPAS......SI.SSSD.......lP...SPGGSNLPNPyANNPgTPQSPGPGQEGQR.STTSLMWTPTPQTRTTAEgllkEVLGQFR.AL..GLLAKlRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     264.50|      67|     123|     799|     865|       3
---------------------------------------------------------------------------
  799-  865 (107.33/54.48)	IPEIASLARAASDDSDSSSEASDA...SGNDSGDEEVEVTPAAIMNSLSM.....PAKRKLQSEGNATPLSVTSF
  920-  990 (93.15/46.26)	LPGPAQMPDTPTSQPDPAYEVPDEkplSAKDSISITQIVTDQLVSTTLDMlsedpP....IRSEFNNDAVAETPW
  991- 1036 (64.02/29.37)	YKVIKNLFPTAT.DCDLPTLA...........GVNEVFQDYAALAKAQQR.....PPARKSDS............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.93|      19|     128|    1061|    1082|       7
---------------------------------------------------------------------------
 1061- 1082 (32.19/25.65)	WDLlppAVAFWETLGLSPISHP
 1195- 1213 (39.74/22.29)	WEL...CSAFWALFQAYTQGHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.23|      21|      24|     461|     481|       8
---------------------------------------------------------------------------
  461-  481 (40.05/19.82)	HPSSPLNARGGT...YGDLQAVSG
  483-  506 (37.18/17.83)	YPTPPDGIAPGTgvsYSDTPTVSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.09|      15|      27|     549|     565|       9
---------------------------------------------------------------------------
  549-  565 (24.48/23.85)	TD.NFNTSSGNDDLfeDM
  578-  593 (26.60/17.28)	TDfDFFDGPDNDDV..DM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30811 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AGARYSLPTLLPGPAQMPDTPTSQPDPAYEVPDEKP
2) AKYQGGRFSAHRPTTPTGQVQLSPSPARNTAATQPKSLR
3) ATTNLPFPSSTSSSANAPASSISSSDLPSPGGSNLPNPYANNPGTPQSPGPGQEGQRSTTSLMWTPTPQTRTTAEGLL
4) GAIKAIDLVRPPMRPGAPHPAATSNHPPSTNAPQRGLQSGNNPRPAQGSTQPQPSADPPPPPD
5) IASLARAASDDSDSSSEASDASGNDSGDEEVEVTPAAIMNSLSMPAKRKLQSEGNATPLSV
6) LEARKKAKKAEEDAVRRKEEHPGLHPSSPLNARGGTYGDLQAVSGVYPTPPDGIAPGTGVSYSDTPTVSGTASNVVLVAGGSNPAINLSAPPDSAKTEDQQMITTSPAVPSATDNFNTSSGNDDLFEDMEEDGYTGDRINDTDFDFFDGPDNDDVDMLDAPALPNDNAPPTHATQDLHPKAATEPQAQDDMSDPFAALENALGTASEPAMSQDLAKGKEPAHMPAPKIEISDNAGDNQSSPVRRKVSFSRAPTPPLSPSKILKALEPSPPRKSASRTRSERGSESHPDAHFTPVVFNRKM
7) PYQFTPTVPNPTPATGAGATTPGSTPQAGVSPSDPGPGLTPAATPAADPTATDPAADPEARL
8) TRTANTTTTSTTSPQSSKQPPPSSSPSEDTRAVEAELRHAL
910
741
1548
112
802
437
1410
28
945
779
1625
174
862
736
1471
68










Molecular Recognition Features






MoRF SequenceStartStop




1) FPLLSKLRL
2) MEEDGYT
3) SKILKAL
781
565
695
789
571
701