<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30807

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQNRGSGLPPRSQVQRRPTKPISTLVQPDCIDPALEDDRPPTHNAAPDAARPPPRGRPPLFYTAMPNYALDMPIHAFPYQPTANLPLPPRPGSIHLRDASQQRRIWPGGSGVKDTPKPGASEAVAPPVHFPGGKAADVFPWTGNSAEDNLSEALVKVGVSNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQAPNTFKPPPRLTLRDSTREQWLHDLANPTTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIGGIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVNGLDTCASERLFIWLLVVSISHYWADVTCCRRRGKRLAESLLNQLDRIYRLEEQGPYMAVLQYLENTVVRLLATRPACLLLPTSWAQYSPLLQKLAERRNHAHVTQAIRRLEQRNCRLLKSPQKPSFASQTPAGRVYRILDSVDYNRPVRIEDLSYDCMEVIGDAPRLIGVLLRWTCTYYREGAHRVYLATRLLRRWNHLGADVYDGIVSYLREMTWVATGDPSLLFKVVAELVRSKTFALGRYLQWLIATGSVGHGADLSVPGSWPLRLVTEIPLTGLPDQIRTLRSTLLRGTVHSAESEQRALTYAKHMISQTLPSLFGLYSSTTDVNEVELDKLSATVKFELGIWLRRQVAQYAEVNEHVPTKDAPGEETAAVSLLTALDFHIVRSYLERFGDLAILADVVGIATSSLDSSVLASTADTINYHAKAFRAIGAFDPLFARVTARYAALRTIRFPDRELLLSLASLARTAQTDGQLPQLLSYDLSQLSQRNTIACSPASDNMGEVMQTGSSSDDEIERILSSGTSMDQQMMGRVLRKIVSNIEEHSGKGSVHLNSHHGWFHRLRCFDEPTFDIVVNEWLASSLMAQRTDSLRVALPTLAGSGCVALTSFLETLRACVARFKTSPSEGCFQSALKGMHIILPSDALAQSCSPQDAYRYRLEQRKLCLETEGRFMQCLGELIGLGSIISSHKTQTQLASLLRSRPVLSILNTHIATDPGCLSKLSKDVSGDCLNQSLDTLLDPNDHLGLSQKPPEQQVAAVFSLASELSLPICQAAIERIFSSRANASEGPSEALSATLLNAIRAAVEEDRPSGLELLASLDASLTGQIRQNAEREIINASAFLTAMSTTKPEETEIVSPKTVQKFLAVIDLTPSKGAENMEQSGLLQALVERLKGMTQALDDNKLSVLDFYAWLTALLRLAVSHASTMISNATHPYQTAIMSAMAALLTHPTLELYPTITEHVFDVTVFLSDYISDDVRFHVTRLDGARLANDSRCVFILGVTAPVDGWLVLARPVNAPPNQSSSQPPTPTPLQGQPTPYQNPQAQATGSSTPQQRYSSQQQQRQQQMQAAQQAQQTRNMQQYSQHPQNKMLPAQLQRTPSGQATPSPLSQMQQMQQMQQRAMQPSPVYSQRPAPTASQGQGVMQAPGKLQLKQEKEIRHYPFVQPRWEILAESSGNPTGNETAINLSLFGARRV
Length1556
PositionKinase
OrganismCochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern corn leaf blight fungus) (Bipolaris maydis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.289
Instability index51.89
Isoelectric point8.82
Molecular weight171944.05
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30807
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.35|      17|      18|    1456|    1472|       1
---------------------------------------------------------------------------
 1434- 1451 (20.86/ 7.04)	QAQQTRNmQQYSQHPQ.NK
 1456- 1472 (31.45/14.53)	QLQRTPS.GQATPSPL.SQ
 1475- 1492 (24.03/ 9.28)	QMQQMQQ.RAMQPSPVySQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     213.90|      48|      52|      51|      98|       2
---------------------------------------------------------------------------
    4-   38 (28.02/ 9.35)	..........................RPgPGIHESLQ..NR.....GSGLPprsqVQRRPTKPIST.LV
   51-   98 (94.85/52.39)	RPPT.H.NAAPD..AARPP...P.RGRP.PLFYTAMP..NY.....ALDMP....IHAFPYQPTAN.LP
  102-  152 (61.89/31.16)	RPGSiHlRDASQ..QRRIW...P..GGS.GVKDTPKPgaSE.....AVAPP....VH.FPGGKAADvFP
 1375- 1414 (29.14/10.07)	RPV....NAPPNqsSSQPPtptPlQGQP.....TPYQ..NPqaqatGSSTP..................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.55|      52|      90|    1148|    1200|       3
---------------------------------------------------------------------------
 1148- 1200 (77.09/56.00)	SEGPSEALSATLLNAI.......RAAVEEDRPSGLELLASLDASLTGQIrQNAEREIINA
 1235- 1293 (76.46/50.86)	SKGAENMEQSGLLQALverlkgmTQALDDNKLSVLDFYAWLTALLRLAV.SHASTMISNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     195.45|      56|      89|     968|    1024|       4
---------------------------------------------------------------------------
  927-  957 (27.47/12.02)	........................CFDEPT..FDIVV.NEWLASS....LMAQrtDSLRVAL...
  968- 1024 (94.44/67.17)	LTSFLETlRACVARFKT..SPSEGCFQSALKGMHIILPSDALAQS....CSPQ..DAYRYRLEQR
 1057- 1112 (73.54/46.99)	LASLLRS.RPVLSILNThiATDPGCLSKLSKD....VSGDCLNQSldtlLDPN..D..HLGLSQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.82|      22|      55|     560|     584|      12
---------------------------------------------------------------------------
  560-  584 (36.04/36.83)	HlGADV.YDGivSY.LREMTWVA.TGDP
  617-  641 (30.78/19.45)	H.GADLsVPG..SWpLRLVTEIPlTGLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.12|      16|      90|     750|     770|      13
---------------------------------------------------------------------------
  750-  770 (19.59/22.84)	SYlerfgDLAILADVVGIATS
  843-  858 (27.52/15.96)	SY.....DLSQLSQRNTIACS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.01|      14|      17|     809|     823|      22
---------------------------------------------------------------------------
  809-  823 (20.06/17.57)	AAL.RTIRfPDREL..LL
  826-  842 (14.94/ 6.03)	ASLaRTAQ.TDGQLpqLL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30807 with Med12 domain of Kingdom Fungi
Unable to open file!