<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30802

Description Uncharacterized protein
SequenceMTSRPGPGIHESLQNRGSGLPPRSQVQRRPTKPISTLVQPDCIDPALEDDRPPTHNAANDAARPPPRGRPPLFYTAMPNYALDMPIHAFPYQPTANLPLPPRPGSIHLRDASQQRRIWPGGSGVKDTPKPGASEAVAPPVHFPGGKAADVFPWTGNSAEDNLSEALVKTGISNKPQIMNESNTARPSLINNLKNKSGLSTLSTLFVAVLEKRQQTGRLQTPNTFKPPPRLTLRDSTREQWLHDLANPTTGLRRLSRTIPHGLTGKVLLEQCLNKNIPLPRALWLAKCVGINELRAHKRKGQAGTVTWGRGWTSSVEQFIDGVIGGIGQGDWKPRITYALQLATHLYKEHLLDDDHFLDWIVNGLDTCASERLFIWLLVVSISHYWADVTCCRRRGKRLAESLLNQLDRIYRLEEQGPYMAVLQYLENTVVRLLATRPACLLLPTSWTQYSPLLQKLAERRNHAHVTQAIRRLEQRNCRLLKSPQKPSFASQTPAGRVYRILDSIDYNRPVRIEDLSYDCMEIIADAPRLIGVLLSWTCTYYREGAHRVYLATRLLRRWNHLGADVYDGIISYLREMTWVATGDPSLLFKVVAELVRSKTFALGRYLQWLIATGSVGHGADLSVPASWPLRLVTEIPLTGLPDQIRTLRSTLLRGTVHSAELEQRALTYAKHMMSQTLPSLFGLYSSTMDVNEVELEKLSPTVKFELGIWLRRQVAQYAEVNEHVPTKDAPGEETAAVSLLTALDFHIVRSYLERFGDLAILADVVGITTSSLDSSVLASTADTINYHAKAFRAIGAFDPLFARVTARYAALRTIRFPDRELLLSLASLARTAQTDGQLPQLLNYDLSQLSQRNSLVACSPASDNMGEVMQTGSSSDDEIERILSSGTSMDQQMMGRVLRKIVSNIEEHSGKGSVHLNSHHGWFHRLRCFDEPTFDMVVNEWLASSLMAQRTDSLRVALPTLAGSGCVALTSFLETLRACVARFKTSPSEGCFQSALKGMHIILPSDALAQSCSPQDAYRYRLEQRKLCLETEGRFMQCLGELIGLGSIISSHKTQTQLASLLRSRPVLSILNTHIATDPGCLSKLSKDVSSDCLNQSLDTLLDPNDHLGLSQKPPEQQVAAVFLLASELSLPICQAAIERIFSSRANASAGPSEALSATLLNAIRTAVEEDRPSGLELLASLDASLTGQIRQNAEREIINASAFLTAMSTTKPEESEIVSPKMVQKFLAVIDLTPSKGAENAEQSGLLQALVERLKGMTQALDDNKLSVLDFYAWLTALLRLAVSHASTMISNATHPYQTAMMSAMAALLTHPTLELYPTITEHVFDVTVFLSDYISDDVRFHVTRLDGARLANDSRCVFILGVTAPVDGWLVLARPVNAPPNQSSSQPPTPTPLQGQPTPYQNPQAQATGSPTPQQRYASQQQQRQQQMQAAQQAQQTRNMQQYSQHPQNKMLPAQLQRTPSGQAIPSPLSQMQQMQQMQQRAMQPSPVYSQRPTPAAGQGQAVTQAPGKLQLKQEKEIRHYPFVQPRWEILAESSGNPTGNETAINLSLFGARRV
Length1557
PositionKinase
OrganismCochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and spot blotch fungus) (Bipolaris sorokiniana)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.283
Instability index52.11
Isoelectric point8.82
Molecular weight172274.66
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30802
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     204.01|      46|      52|      51|      98|       1
---------------------------------------------------------------------------
   52-   98 (83.24/43.59)	PPT.H.NAANDAARPPP.RGRPPLFYTAMP..NYALDMPIHaFPYQPTAN.LP
  103-  152 (59.65/25.19)	PGSiHlRDASQQRRIWP..GGSGVKDTPKPgaSEAVAPPVH.FPGGKAADvFP
 1381- 1420 (61.13/28.49)	PP..N.QSSSQPPTPTPlQGQPTP.YQNPQ..AQATGSPT...PQQRYA....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      52.26|      10|      20|    1424|    1433|       2
---------------------------------------------------------------------------
 1424- 1433 (19.10/ 9.86)	QQRQQQMQAA
 1447- 1456 (16.78/ 7.60)	QHPQNKMLPA
 1468- 1477 (16.37/ 7.20)	PSPLSQMQQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     506.29|     132|     152|     892|    1043|       3
---------------------------------------------------------------------------
  784-  878 (128.45/64.48)	.........................INYHAKAFRAIGAFD.PLFARVTARYAALRT..IRFPDRELLLSL..ASL...................AR..TAQTDGQLPQLLNyDLSQLSQRNSLV.ACSPASDNMGEVMQ.TGSSSDDE
  899- 1032 (218.54/156.44)	RKIVSNIEEHSGKGSVH........LNSHHGWFHRLRCFDEPTFDMVVNEWLASSL..MAQRTDSLRVAL..PTLAGSGCVALTSFLeTLRACVARFKTSPSEGCFQSALK.GMHIILPSDALAqSCSPQDAYRYRLEQ.RKLCLETE
 1046- 1177 (159.29/83.48)	GSIISSHKTQTQLASLLrsrpvlsiLNTHIA..TDPGCLSKLSKD.VSSDCLNQSLdtLLDPNDHLGLSQkpPEQQVAAVFLLASEL.SLPICQAAIERIFSSRANASA...G.....PSEAL..SATLLNAIRTAVEEdRPSGLE..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.21|      21|      54|     182|     202|       4
---------------------------------------------------------------------------
  182-  202 (34.51/20.96)	NTARPSLINNLKN.KSGLSTLS
  234-  255 (32.70/19.47)	DSTREQWLHDLANpTTGLRRLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.45|      32|      89|    1252|    1283|       7
---------------------------------------------------------------------------
 1252- 1283 (53.92/36.21)	VERLKGMTQALDDNKLSVLDFYAWLTALLRLA
 1344- 1375 (55.53/37.52)	VTRLDGARLANDSRCVFILGVTAPVDGWLVLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.70|      31|      89|     425|     471|      10
---------------------------------------------------------------------------
  427-  465 (48.88/41.50)	NTVVRL..........LATRPACLLLPTSWTqyspllqkLAERRNHAHV
  507-  547 (48.82/21.82)	NRPVRIedlsydcmeiIADAPRLIGVLLSWT........CTYYREGAHR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.55|      10|      15|    1288|    1297|      12
---------------------------------------------------------------------------
 1288- 1297 (19.29/12.19)	STMISNATHP
 1304- 1313 (18.25/11.10)	SAMAALLTHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30802 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARPVNAPPNQSSSQPPTPTPLQGQPTPYQNPQAQATGSPTPQQRYASQQQQRQQQMQAAQQAQQTRNMQQYSQHPQNKMLPAQLQRTPSGQAIPSPLSQMQQMQQMQQRAMQPSPVYSQRPTPAAGQGQAVTQAPGKLQLKQEKEI
2) HAFPYQPTANLPLPPRPGSIHLRDASQQRRIWPGGSGVKDTPKPGASEAVAPPVH
3) LSEALVKTGISNKPQIMNESNTARPSLINNL
4) MTSRPGPGIHESLQNRGSGLPPRSQVQRRPTKPISTLVQPDCIDPALEDDRPPTHNAANDAARPPPRGRPPLFYTA
1375
87
162
1
1520
141
192
76










Molecular Recognition Features






MoRF SequenceStartStop




NANANA