<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30799

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDGASYNMDVDDLFGDSEHVNIQTINTTPPVKGRDARIDELGSTGCCQKISWSKNGCVAYITPDGYSVNLKIFSRNPETGKWALGKTVPLELPHGSEVFPLIHLSWSHLGNDLAVMDQAGRVMIFSCAMALDRMHFARAEIAHPESEVDAVVGMHWLAILPYAQKNLIAWSAAREGNKWKWNIRQHLFNNAHHPVDGKASLIYLKRYGELKLRFQQNDNNWQETSTQLGPMISTKESFTHAAFASNNDNTLLLAAYDVKRRLHLYRVETIWNVPADKRSQNAGPFEKPAIQVSLLALEDTCNPVDMATDELSNGGTSESAAAAAAQLTHLDFLPVTPQQDDGSVPTIQAIFCKPPNPISYDMNPQETRYSIIVKWQVHQEQQNQLHPSLEQVTSKKKSVSSLPAQTTFLLKRQPDAALHSVVLDFYPMWYNMLLAFCYSDGLIEFRKRSTMEVIMPDDNTDNVTSLLQAGFVFQHAEPSLHVAFSPNHCVAVGMQLDGTTKLRLMEYTHGTLSAEDDDPHHSAALAALILQSSSAANQYFSSDDIFAIIDSMSDKRKQDFITLLFEGLQVNIDCGIDDSSTNHFILLGRSPFFVKTLSAMHLLGLQGTINRTLVSKTAWQILNIKYVTQILTTIVRMHGDVSKINLRPEAVPQMIGTIRWTMHFMAYILDDLFALGRALSDIPPADLTRDVLESKIKETNKPAILLLLSAFPRAMMKLWAQPIQWVKRSAESHATNPSAPGGPVPVQSPESKRLYTPLLSAVSELPFEWRWFEVLVTETTAHTRAIYKQRNLNDAQRNSIEREILLGKIPDILFPVAKRLVTDALWNSNQQNSCLADKLDMGKLMFFDTTWLGFTDSKRARVWHDEHVVDVCQKMIIRGVGTWVHPVNTSGHHLMGGRGRSDSLQSAAGGAGGASAGGAGTVNGESGSERKGRNMLRQCVRCGACMEDVVPGLQGYTIHHYQWLVGVSKHCVCGNSWMLVETKPSLK
Length987
PositionTail
OrganismCochliobolus heterostrophus (strain C5 / ATCC 48332 / race O) (Southern corn leaf blight fungus) (Bipolaris maydis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.08
Grand average of hydropathy-0.226
Instability index43.55
Isoelectric point6.48
Molecular weight109920.18
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30799
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.70|      22|     110|     677|     698|       1
---------------------------------------------------------------------------
  677-  698 (35.85/23.82)	RALSDIPPADLTRDVLESKIKE
  790-  811 (36.85/24.68)	RNLNDAQRNSIEREILLGKIPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.61|      47|     272|     198|     249|       2
---------------------------------------------------------------------------
  198-  249 (75.99/63.91)	KASLIYLKRYGELKLRFQQNDN...NWQ.ETSTQLGPMistkeSFTHAAFASNNDN
  468-  518 (74.63/51.54)	QAGFVFQHAEPSLHVAFSPNHCvavGMQlDGTTKLRLM.....EYTHGTLSAEDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.75|      44|     272|      35|      78|       5
---------------------------------------------------------------------------
   35-   78 (80.72/49.78)	DARIDELGSTGCCQKISWSKNGCVAY....ITP...DGYSVNLK.IFSRNPE
  305-  356 (61.03/35.90)	DMATDELSNGGTSESAAAAAAQLTHLdflpVTPqqdDGSVPTIQaIFCKPPN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.03|      48|     719|     106|     154|       7
---------------------------------------------------------------------------
  106-  154 (81.24/61.47)	WSHLGNDLAVMDQ..AGRVMIFSCAMaLDRMHFARAEIAHPESEVDAVVGM
  826-  875 (85.79/60.40)	WNSNQQNSCLADKldMGKLMFFDTTW.LGFTDSKRARVWHDEHVVDVCQKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.21|      24|     656|      79|     102|       8
---------------------------------------------------------------------------
   79-  102 (44.08/30.03)	TGKWALGKTVPLELPHGSEVF.PLI
  735-  759 (40.13/26.60)	TNPSAPGGPVPVQSPESKRLYtPLL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30799 with Med16 domain of Kingdom Fungi
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