<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30793

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDGASYNMDVDDLFGDSEHVNIQTINTTPPVKGRDARIDELGSTGCCQKISWSKNGCVAYITPDGYSVNLKIFSRNPETGKWALGKTVPLELPQGSEVFPLIHLSWSHLGNDLAIMDQAGRVMIFSCAMALDRMHFTRAEIAHPESEVDAVVGMHWLAILPYAQKNLIAWSAAREGNKWKWNIRQHLFNNAHHPVDGKASLIYLKRYGELKLRFQQNDNNWQEASTQLGPMISTKESFTHAAFASNNDNTLLLAAYDVKRRLHLYRVEMIWNVPADKRSQNAGPFEKPTIQVSLLALEDTCNPVDMANDELSNGGTSESAATAAAQLTHLDFLPVTPQQDDGSVPTIQAIFSKPPNPISYDMNPQETRYSIIVKWQVHQEQQNQLHPSLEQVTSKKKSVSSLPAQTTFLLKRLPDFALHSVVLDFYPMWYNMLLAFCYSDGSIEFRKRSTMEVIMPDDNTDNVTSLLQAGFVFQHAEPSLHVAFSPNHCVAVGMQLDGTTKLRLMEYTHGTLSTDDDDPHHSAALAALILQSSSAANQYFSSDDIFAIIDSMSDKRKQDFITLLFEGLQVNIDCGIDDSSTNHFILLGRSPFFVKTLSAMHLLGLQGTINRTLVSKTAWQILNIKYVTQILTTIVRMHGDVSKINLRPEAVPQMIGTIRWTMHFMAYILDDLFALGRALSDIPPADLTRDVLESKIKETNKPAILLLLSAFPRAMMKLWAQPIQWVKRSAESQAATTTNPSASVPVQSPESKRLYTPLLSAVSELPFEWRWFEVLVTETTAHIRAIYKQRNLNDAQRNSIEREILLGKIPDILFPVAKRLVTDTLWNSNQQNACLADKLDMGKLMFFDTTWLGFTDSKRARVWHEEHVVDVCQKMIIRGIGTWVHPVNTAGHHLMGRGRSDSLQSAGGGASGTANGDSGSERKGRNMLRQCVRCGACMEDVVPGLQGYTIHHYQWLVGVSKHCVCGNSWMLVETKPSLK
Length979
PositionTail
OrganismCochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and spot blotch fungus) (Bipolaris sorokiniana)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.08
Grand average of hydropathy-0.232
Instability index43.96
Isoelectric point6.45
Molecular weight109589.87
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30793
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     287.71|      95|     395|     336|     440|       1
---------------------------------------------------------------------------
  336-  440 (147.65/127.12)	TPQQDDGSVPtIQAIFSKP.PNPISYDMN..PQETR.YSIIVkwqvhQEQQNQLHPSLEQVTSKKKSVSSLpaQTTFLLKRLPD..FAL.HSVVLDfyPMWYNMLLAFCYSD
  736-  837 (140.06/91.91)	TTTNPSASVP.VQSPESKRlYTPLLSAVSelPFEWRwFEVLV.....TETTAHIRAIYKQRNLNDAQRNSI..EREILLGKIPDilFPVaKRLVTD..TLWNSNQQNACLAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.22|      26|     167|     459|     492|       5
---------------------------------------------------------------------------
  461-  490 (37.86/41.78)	DNVTSLLQaGFVFQHAEPSLHVAfspNHCV
  939-  964 (50.36/24.81)	EDVVPGLQ.GYTIHHYQWLVGVS...KHCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.09|      18|     126|     543|     560|       8
---------------------------------------------------------------------------
  543-  560 (32.36/23.81)	DDIFAIIDSMSDKRKQDF
  670-  687 (31.73/23.18)	DDLFALGRALSDIPPADL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30793 with Med16 domain of Kingdom Fungi
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