<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30789

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEFLKTCTTNAQAIGDFEAIAYQAISVTRTTTNTTTTTSTTSPQSSRQPPPSWSPSEDTRAVEAELRHALHLVAHDAARPWLWLFKPTTVDKLGQASPQLPELDGYRLQREHTGAIKAIDLVRPPMRPGAPHPPATSNHTTSTNAPQRGLQSGNNPRPAQGSTHPQPSADPPPPPDCFTLYELFTSSVVALISFHVVKDCQVVALNYRTFVSKASKCIADGQTEVDPQPEVHRLTSINVHWASSGTLLLSTFTDRKNTIRCLSSVSTQTEERQLVGTCIRVAPNGVLATIISFEDPLDSINEEISIRHRKRTKSTSLEQNIEKWKSGVKRWLGWKGYDLPDLDQRTSWVRIHTTLTPSPILSSPVSVGPERDILWPRALCFFHVINETDLTVTGTNTIGAAGNSNILRWFETPESMGFKDPLDVAQEWFLGKPDRDKILEARKKAKKAEEDAVRRKEEHPGLHPSSPLNARGGTYGDLQPVSGVYPTPPDGIAPGTGVSYSDTPTVSGAASNVVLVPGGSNPAINISAPPDSAKTEDQQMVTTSPAVPSATDNFNTSSGNDDLFEDMEEDGYTGDRINDTDFDFFDGPDNDDVDMLDAPALPNDNAPPTHATQDPHPKAATEPQAQDDMSDPFAALENALATASEPAMSQDHTKGKEPAHMPAPKIEISDNSGDTKSSPVRRNVSFSRAPTPPLSPSKILKALEPSPPRKSASRTRSERGSESHPDAHFTPVVFNRKMSLSDAKYQGGRFSAHRPTTPTGQVQLSPSPARNTGATQPKSLREFPLLSKLRLAAGIASANRIPEMASLARAVSDDSDSSSEVSDASGNDSGDEEVEVTPAAIMNSLTMPAKRKLQSEGNATPLSVTSFAESLGGDWLDLYGLHLDEANLSSFEPSLWDWSLVNVPSPAERPVAGARYSLPALLPGPAQMPDTPTSQPDPAYEVPDEKPLSAKDSISITQIVTDQLVSTTLDMLSEDPPIRSEFNNDAVAETPWYNVIKNLFPTATDCDLPTLAGVNEVFQDYTALAKAQQRPPARKSDSPAVTGSHMYQIQAPFLRVRRAETHWDLLPPAVAFWETLGLSPISHPKNIVTFCVYPHSDAIRPCLENFLLNLQLAYDGCKLGNHSRVETAVEYEGGLVPVRATSTITPRETFKLLKDTCIQLGKLLALQYGQIREQQDFKVDAFVIYMIDPFGGSSAVWELCSAFWALFQAYTQGHPGRPDQPQKPDVVLQIIPMKYVASFDAPVILDPSTYMGLAREVYDRCPPSAPSGDKTSLSIYKAPAFHLEETLPRNIPFKLISEPAQDLLRENTYMHLGYAISLDGAWVTAAWTDSCGKSQAVVSYYLGTRMFREIAKEIWQTTIEILQSRRVNWRVCIAKAGVLEREELETWVFLISCPTQINVFVTLLTAVDTDPPYQFTPTVPNSTPATGAGATTPGSTPQAGVSPSDPGPGLTPAATPATDPTATDPAADPEARLIDVTDDTWGIILAHRLHNSHTTTQFSPALISGLLVKRGETLQTSNSIAHLIPDAEQGPIVIAVNFLWIGAVGSSRNATTNLPFPSSTSSSANASASSSISSSDLPSPGGSNLPNPYANNPGTPQSPGPGQEGQRSTTSLMWTPTPQTRTTAEGLLKEVLGQFRALGLLAKLRGMRGTKNGTIPWHVAAAKRGVEGLSKISGGAGAAV
Length1680
PositionKinase
OrganismCochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and spot blotch fungus) (Bipolaris sorokiniana)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.07
Grand average of hydropathy-0.394
Instability index48.06
Isoelectric point5.36
Molecular weight181530.24
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30789
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     217.62|      28|      30|    1423|    1450|       1
---------------------------------------------------------------------------
  124-  150 (39.92/15.85)	.PPMRPGA.P...HPPAT..SNHT.TSTNA...PQR..GL
  460-  481 (25.99/ 7.15)	.....PGL.....HPSSP..LNAR.GGTYG...DLQ..PV
  606-  636 (35.51/13.09)	APPTHATQdP...HPKAAtePQAQ.DDMSD...PFA..AL
  645-  680 (25.80/ 7.03)	EPAMSQDH.TkgkEPAHM..PAPK.IEISDnsgDTKssPV
 1423- 1450 (48.20/21.03)	TPATGAGA.T...TPGST..PQAG.VSPSD...PGP..GL
 1455- 1483 (42.19/17.27)	TPATDPTA.T...DPAAD..PEARlIDVTD...DTW..GI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.25|      22|     129|     291|     313|       2
---------------------------------------------------------------------------
  291-  313 (34.15/28.78)	ISFEDPLDsINEEISIRHRKRTK
  416-  437 (42.10/30.56)	MGFKDPLD.VAQEWFLGKPDRDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     286.01|      91|     129|    1072|    1200|       3
---------------------------------------------------------------------------
 1072- 1167 (152.89/143.56)	FWETLGLSPISHP.......KNIVTFCVYPHS.....DAirPCLENFLLNLQLA...YDGCKLGNHSRVETAVE.YEgglVPVRATSTITPRE.TFKLL.........KDTCIQLGKLLALQ
 1203- 1319 (133.11/65.64)	FWALFQAYTQGHPgrpdqpqKPDVVLQIIPMKyvasfDA..PVILDPSTYMGLArevYDRCPPSAPSGDKTSLSiYK...APAFHLEETLPRNiPFKLIsepaqdllrENTYMHLGYAISLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.49|      19|     128|      33|      51|       4
---------------------------------------------------------------------------
   33-   51 (35.79/15.02)	NTTTTTSTTSPQSSRQPPP
  155-  173 (38.70/16.89)	NPRPAQGSTHPQPSADPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.75|      15|      15|     754|     768|       5
---------------------------------------------------------------------------
  754-  768 (27.88/13.71)	RPTTPTGQVQLSPSP
  770-  784 (26.86/12.91)	RNTGATQPKSLREFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.53|      17|     128|     905|     923|       6
---------------------------------------------------------------------------
  898-  914 (29.70/ 8.56)	WSL.VNVPSPAERPVAGA
  916-  933 (28.82/16.67)	YSLpALLPGPAQMPDTPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      14|      15|    1546|    1559|       7
---------------------------------------------------------------------------
 1546- 1559 (25.53/15.74)	SSRNATTNLPFPSS
 1562- 1575 (22.16/12.46)	SSANASASSSISSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.53|      17|     124|     261|     284|      10
---------------------------------------------------------------------------
  266-  283 (26.89/28.12)	STQTEERQLVGTCIRVaP
  532-  548 (30.63/ 8.75)	SAKTEDQQMVTTSPAV.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.14|      31|     132|    1497|    1530|      11
---------------------------------------------------------------------------
 1497- 1530 (44.54/34.89)	QFSpALisGLLVK.RGETLQTSNSIAHLIPDAEQG
 1634- 1665 (52.60/29.94)	QFR.AL..GLLAKlRGMRGTKNGTIPWHVAAAKRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.09|      15|      27|     551|     567|      12
---------------------------------------------------------------------------
  551-  567 (24.48/22.66)	TD.NFNTSSGNDDLfeDM
  580-  595 (26.60/16.36)	TDfDFFDGPDNDDV..DM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      12|      15|     723|     734|      15
---------------------------------------------------------------------------
  723-  734 (24.29/13.40)	SHPDAHFTPVVF
  739-  750 (21.63/11.14)	SLSDAKYQGGRF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30789 with Med13 domain of Kingdom Fungi
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