<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30787

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNHTASDAATASRHGDSNTAAPNGASAASTALDKYSQLPPEIAHIGPEQYNALSTLLLRVSQESYNDLTSILQKMAALPVAPMANGALPNGIGAANMQGNAESNKRKKLMLLQFAQEQRSKFIKLLVLTEWGKKAASDISKLIDIFSWAGAHARNMDAADDQLERIKMLSNIARENNPDIATALQVLSTGKASWMPSLDYIPPKPISSDEALKLLRYMNTSLSIRLNVHENLPRHLRNWRIHSGRVTFIIKGQLEFDVMSFVEDASEQWFLIDLRLLFTPAPTVTVGSRFFMQLKQQADFVLKDKGLPGLFDFLNNFILTHKISVLRSQAAALVRAGWAGSLKVEPVHRLLVVQYWTNKPGKKNWIEIGVSNNRLNNAKSSWRGPPTPSLTTRWFRQGKEVKNANFAFDWTNLSMEKVIKLVIARHTSDILRSTKESMKSGVVAETDLSEAEPADCRLNATLGTKSASITLSLEPVTGNHIVRPASALSARAENAFNLGREPAQMAHVMTQVLAGTLLGLIQRNAQQLGWQTVARQSLTPQMVRSAVKLDVISSVLYWPRGWSPNWAFAPIIDSSGESWWILEIGSTGNRIEHAEQIRMNRPDKSPLPINRSTLASLERVAIQLLSFRVTARQLEKEKRMYALEEELGQTPASAQGLRIARRWVLRVQTPDLLTSSTRDDKWLEADIKITCEGLRVGGQNVWHVASGKMVKSVAADMHKLMAASPQKAFKFSDDGNFRILLSTPFGQDILGELRARLRDVNRLRSFATTLQKRRMRLASSSLQRVQFLYGPSPYTATVNFSSEKEVTIELSSKNPHHRILNLLTHIANDRLPSFMSLDPNDANGLDRFCTTLVLTRPLFKVIREIEQRSPGNCRNPAIHVHSILKYRITYENPVCTFDVRLQPKDDQVFWFVEDNLRPKDPNVLPTPERGQGHRRLDNLQEKLKELFSSKGPGWFGTRNGMIAELDAIPDALRKLNECVLSCKMEGGYVAPPPLERPAQHAQNPGQGMSKTNGVQQGNQQQQQQQQQQQHQHQQQQARMQQQQQQQHQARQQQQGQQQMRMQQSNQRVQQPNGRQPQHMQNARQHMQHQQGRGGRPGQTQNNVIEID
Length1107
PositionTail
OrganismCochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and spot blotch fungus) (Bipolaris sorokiniana)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.503
Instability index48.86
Isoelectric point9.85
Molecular weight124468.49
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30787
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.63|      19|      19|    1021|    1039|       1
---------------------------------------------------------------------------
 1021- 1039 (41.10/21.66)	QQQQQQQQQH......QHQQQQARM
 1050- 1068 (34.45/16.94)	RQQQQGQQQM......RMQQSNQRV
 1069- 1092 (25.08/10.30)	QQPNGRQPQHmqnarqHMQHQQGR.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.98|      11|      66|      18|      28|       2
---------------------------------------------------------------------------
   18-   28 (20.56/12.40)	NTAAPNGASAA
   85-   95 (21.41/13.23)	NGALPNGIGAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.46|      21|      66|     583|     603|       3
---------------------------------------------------------------------------
  583-  603 (38.93/24.99)	EIGST.....GNRIEHAEQIRMNRPD
  646-  671 (32.53/19.64)	ELGQTpasaqGLRIARRWVLRVQTPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.17|      55|     141|     314|     396|       6
---------------------------------------------------------------------------
  126-  205 (79.38/30.79)	LVLTEW.GKKAASDISKLIDIFSWAGAHarnmdaaddqlerikmlsniARENNPDIATALQVLSTGKASWMPsldyiPPKP
  333-  388 (96.80/55.69)	LVRAGWaGSLKVEPVHRLLVVQYWTNKP....................GKKNWIEIGVSNNRLNNAKSSWRG.....PPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.81|       7|      19|     553|     562|      11
---------------------------------------------------------------------------
  553-  562 (11.30/13.70)	SSVLYWprgW
  574-  580 (16.51/ 7.51)	SSGESW...W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.59|      28|      62|     813|     841|      13
---------------------------------------------------------------------------
  813-  841 (48.21/38.48)	KNP..H.HRILNLLTHIANDrLPSF.MSLDPND
  874-  905 (40.38/26.52)	RNPaiHvHSILKYRITYENP.VCTFdVRLQPKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.75|      25|      63|     459|     488|      17
---------------------------------------------------------------------------
  459-  488 (32.38/28.40)	NA.TLGTKSASiTLSLEPvtgnHIVRPASAL
  524-  549 (38.36/20.18)	NAqQLGWQTVA.RQSLTP....QMVRSAVKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30787 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGYVAPPPLERPAQHAQNPGQGMSKTNGVQQGNQQQQQQQQQQQHQHQQQQARMQQQQQQQHQARQQQQGQQQMRMQQSNQRVQQPNGRQPQHMQNARQHMQHQQGRGGRPGQTQNNVIEID
2) MNHTASDAATASRHGDSNTAAPNGASAASTAL
986
1
1107
32










Molecular Recognition Features






MoRF SequenceStartStop




NANANA