<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30784

Description Ubiquitinyl hydrolase 1
SequenceMDDVLNEQFGRVERALTTLIDSIAAYNPATQAAIDLVAADDQLSDGLDQLAKHQANHGRIQTLRAEADALEAQLRDSVRKLAELRRELFNTPATTFSPESRAVPFDELLQYATNISRYTVPPTYRERLPTTDKDDDDMGSSGAPTNGMNTPAIVSDAVDLPNDSSEAQKGGEDADGAVPDITAEEEEWLRKLKASNLAWYPWPSTEKIRNGILYRLSYWREKGNDLDQFDIPAYLEEQRKKALGNEASLEETSAEPTEEQPHREAARPTRPLSAFTGLDDMDEMHLKPLHSGTTQINPVALVQMRKTQKRERDVDQVEKVDEAPAKRRRQSIDDQVKLSKLYVDLAAEEDDIRFEAAKQIIVRFAPENKPAAKDVEEALVRLIKGLCSQRKAARVGFSLTLTEFLRQIFGEKKSEIEGLELDVASIIKMVEDKTKPKGNVPGKERRDHTIGKLFGFKAIMQSSILIEPQISLESWNKLLDQVYKMARDIPWLREECGMVLVEAVRSLKGQSQYQKCVEELLERLNSFQLILTPEGVAVWLTVKESYPEALSEGVWHTKDPLSKKERSRLAKILKEDFNKTESEAGKKETTKTGTTNPNPSFTWDLAFAEMLRRDEAAKEDAQNKPEFPQFWIDTVDGNLFSSSASHERKAWGFKLLSSMVTRVPDWAVPALFSPNLMRTLINQSKKEDRFLHSAALAALSSVQLRVEQEDGIALPIFVALTSKNGSVEFDRITKTKTLEQILLSADDKSLMKIIRHLKSLILRPESEDQAVADSRRQSIADLLLSTVKLYKRYEKFNEKTFKKKVAHRQEGRPLDERKSNWLRETLETLVECAYFVPAQNAETKKMPLPPVSDRSRTIFQERLSSCLTKLLDVKLGNRADVALLVIDMIKAKSGKSSKLELVLKADPSILSTIKQASATLANISEAGSIAGNEMAAQGFMLLYSLTLLQVYNGEGDAVMMLDDLDASYKAFEASRKASSKKKKSSTPDGQNAFVEIVLSFSGNTRTLFRRIGEEAFSIFASEISADGLRSLTDILDTEENLEGQRELFDQGDEDVEEDESSDDDEDGDEVDSDVEMIDGEESKDASESDSSDGDSDSEGSSDGEDDEEDAELTQFNNMLAMTLQTSKPNVNGDAAEETSDESDMDDEQMMALDPHLSKIFKERSKTASKKKEREDAKQNVVQFKSRVLDLLAIYMEKQYSNPLTLDILLPVLRRTRANANKQTADKAAKMLKTFFDTRTKHKAPLPKPESTEPVWELLRGIHEEAKLGNGAKVHADACGSASLHVAKVLVGMDRENYAGVVDIYAETQKQWFADKKSPLQPVLFTQFQNWSVNARQQGKLESSNQRHIFSPHSSLTDMACKHVNASELRPPGPMQSVYREDCTQCFDSIDDPTGLDVCLYCFNGGCTSDRSHALLHVSSTNHPIVLNIKRTRKRVQRDEPPQKMTKLAVAAETESDRYDTTTQVKCYECGVDDIDKSSGKLPDIVDAVLKANTFAKQQEVKAWEQELTACEHTLCLEQDAARQIESQKLGHCSECELNENLWLCLSCGNLGCGRQQFGGVGGNSHGVGHTKSTGHPVAVKLGSLTADGTADIYCYACDEERIDPELPDHLAHWGINIKDRVKTEKSLTEMQVEQNLRWDFAMVTEDGKELQPLFGPELTGLKNLGNSCYLNSTLQALFSMPEFKERYYLPDQAPPDAALPAEDLETQLRKIADGMISGRYSKPDTDVITNEQSPEIPHQRGLAPAMLKHLIGRGHAEFSTMRQQDAFELLLHMLKLISRSQHVAPHKDPVDAFRFVMEQRLQCVGCKRVRYRTDEQENISIPVPIRRIPKESQMDVTDGNGKKEEKEEFEPVSLKECIDIFTAEELVELTCSACGSKDGFTKRSMFKTFPSVLAVNARRFELVNWVPTKQDVPVIVNDEPFSFDAYKSNGLSEGEELLPDDVDMGGVGGSAGKWIPNEAALSMLEAMGFPRVRCEKALHATGNEDAEAASNWLFAHMEDPDIDDPVDFNAGSSGNTAAASAIDPEKIENLGAMGFSAPQARQALKETGGDMERAVDWLFSHPDAPGDFEEGGSSDAPADATEKALAGSDKLPANFQLQSIVCHKGSSIHAGHYVAFVRKQLQNEQSASWVLFNDEKVAKAADVEEMKKFAYVYFFRRL
Length2158
PositionMiddle
OrganismCochliobolus sativus (strain ND90Pr / ATCC 201652) (Common root rot and spot blotch fungus) (Bipolaris sorokiniana)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Pleosporineae> Pleosporaceae> Bipolaris.
Aromaticity0.06
Grand average of hydropathy-0.555
Instability index45.98
Isoelectric point5.05
Molecular weight240826.14
Publications
PubMed=23236275
PubMed=23357949

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleolus	GO:0005730	IEA:InterPro

GO - Biological Function
DNA binding	GO:0003677	IEA:InterPro
thiol-dependent deubiquitinase	GO:0004843	IEA:UniProtKB-EC
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
protein deubiquitination	GO:0016579	IEA:InterPro
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
ubiquitin-dependent protein catabolic process	GO:0006511	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30784
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     316.12|      80|     149|    1345|    1424|       1
---------------------------------------------------------------------------
 1345- 1424 (150.46/102.55)	QRHIFSPHSSLTDMACKHVNASELRPPGPMQSVYREDCTQC.FDSIDDPTGLDVCLYCFNGGCTSDR.......SHALLHVSSTNHPI
 1440- 1479 (37.30/19.03)	......PPQKMTKLAVAAETESD.R....YDTTTQVKCYECgVDDIDKSSG.....................................
 1497- 1577 (128.36/86.24)	QQEVKAWEQELT..ACEHTLCLEQDAARQIESQKLGHCSEC...ELNE..NLWLCLSCGNLGCGRQQfggvggnSHGVGHTKSTGHPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.83|      46|     300|     292|     437|       2
---------------------------------------------------------------------------
  344-  399 (64.03/115.02)	DLAAEEDDIRFEAAKQiivrfAPENKPaakDVEEALVRLIKG.LCS.....QRKAarVGFSL
  604-  655 (74.80/11.39)	DLAFAEMLRRDEAAKE.....DAQNKP...EFPQFWIDTVDGnLFSssashERKA..WGFKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      55.26|      18|      21|    1052|    1072|       3
---------------------------------------------------------------------------
 1054- 1065 (16.09/ 7.51)	.......DVEE...DESSDDDE
 1066- 1087 (20.91/ 8.91)	DGDEVDsDVEMidgEESKDASE
 1089- 1104 (18.26/ 8.11)	DSSDGD......sdSEGSSDGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     447.73|     151|     396|    1558|    1733|       4
---------------------------------------------------------------------------
 1558- 1733 (240.77/192.95)	GGVGG.......NshgvghtkstghpvAVKLGSLTADGTADIYC....YACDEEriDPELPDH..LAHW.GINIKDRVKTEKSLTemqveQNLRWDFAMVTEDGKELQPL.F.GPEL.TGLKNLGNScyLNSTLQALFSMP....EFKERYylPDQAPPDA...ALPAED...LETQLRKI....ADGMISGRYSKPDTDVITNEQS
 1945- 2126 (206.96/138.42)	GGVGGsagkwipN..............EAALSMLEAMGFPRVRCekalHATGNE..DAEAASNwlFAHMeDPDIDDPVDFNAGSS.....GNTAAASAIDPEKIENLGAMgFsAPQArQALKETGGD..MERAVDWLFSHPdapgDFEEGG..SSDAPADAtekALAGSDklpANFQLQSIvchkGSSIHAGHYVAFVRKQLQNEQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.01|      20|      21|     137|     156|       5
---------------------------------------------------------------------------
  137-  156 (36.04/18.17)	DM..GSSGAPTNGMNTPAIVSD
  159-  180 (27.97/12.52)	DLpnDSSEAQKGGEDADGAVPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.75|      22|     401|     746|     861|       6
---------------------------------------------------------------------------
  823-  844 (35.97/134.48)	RETLETLVECAYFVPAQNAETK
 1294- 1315 (37.78/34.43)	RENYAGVVDIYAETQKQWFADK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.56|      17|     402|     845|     861|       7
---------------------------------------------------------------------------
  845-  861 (33.08/18.42)	KMPLP......PVSDRSRTIFQE
 1242- 1264 (27.47/14.02)	KAPLPkpestePVWELLRGIHEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.74|      17|      20|     296|     315|       8
---------------------------------------------------------------------------
  299-  315 (26.88/22.37)	VALVQMRKTQKRERDVD
  317-  333 (26.86/11.75)	VEKVDEAPAKRRRQSID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.07|      19|      20|     550|     568|       9
---------------------------------------------------------------------------
  550-  568 (34.66/22.09)	LSEGVWHTKDPLSKKERSR
  573-  591 (29.41/17.49)	LKEDFNKTESEAGKKETTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.87|      21|     402|     746|     767|      10
---------------------------------------------------------------------------
  746-  767 (31.32/29.42)	DDKSLMKIIRHLkSLILRPESE
 1145- 1165 (37.55/29.68)	DDEQMMALDPHL.SKIFKERSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.42|      16|      19|    1018|    1033|      13
---------------------------------------------------------------------------
 1018- 1033 (26.21/17.52)	IFASEISADGLRSLTD
 1034- 1049 (27.21/18.53)	ILDTEENLEGQRELFD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30784 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KKALGNEASLEETSAEPTEEQPHREAARPTRPLSAFTGLDDMDEMHLKPLH
2) SLTDILDTEENLEGQRELFDQGDEDVEEDESSDDDEDGDEVDSDVEMIDGEESKDASESDSSDGDSDSEGSSDGEDDEEDAELTQFNNMLAMTLQTSKPNVNGDAAEETSDESDMDDEQMMALDPHLSKIFKERSKTASKKKEREDAKQN
3) VPPTYRERLPTTDKDDDDMGSSGAPTNGMNTPAIVSDAVDLPNDSSEAQKGGEDADGAVPDITAEEE
240
1030
120
290
1179
186










Molecular Recognition Features






MoRF SequenceStartStop




1) DEQMMALD
2) GILYRLSYWR
1146
211
1153
220