<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30783
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MSGVVSNGASSFDPSHGQPFTNGFHEPSIEELLHELPVVQDGQVPLGELVSRVAQALYAELSELAETMPNMSDAARKRVLADWVVHSKKQVVKLYAVVKWARDAEVVQKAMNVTAFLMDQNRQFEDAVHGLKYAKDSLDPARLRNHDLLTALDVLTTGSYRRLPSCIKKAIIPQTPLTDEEVAKTLADIEDAMRYRLRMTEIIPVEMSRYCIDKGRVHFTAPRLFETSLCLKGAQSNDGWFVVDVEFLFNVGGDQSGLQDFPRRPSGMLKRHILDEGDARLAFYLPLPADQQPPPGVELPPRPQLPDGFADAPLVRLYNFLQMMSLSYQLEIMWFQGERLRSLGWADYLTIGMTNNRQTLTVSYWIRRSPSETAGRPQPPNRAKLPLLGGTLTISIVPVQPKPGSKSSRSPKDRILAELQQRAKLDIARPSDEVESFKLDVKWQPEIGALGVGIPPEDACLSEAELQINSEDLDLEALLRKVITKHTEAILKVFKFQLQHGPSRNVFSDPGEVELISEDGSYTLRTHLCADEIVVVTIDARTGRLNLRDTGDLAAAGRGSRFALLTQTLNENPTMLVQLLVTLKFSTITEAVEQKAKYLGLQSYRIRNFPREELQKLGPARGTLYIQLSRFPNHYLVLVITDEDFRYALISVKVLSETVHANMIMEDIGWLDVRRIHGDELAIHLQNVTLDGDDTVVGQRRKRGPDDVGGRTDSVQRFSSRFNLDTKTLRELYAYCW |
Length | 737 |
Position | Tail |
Organism | Ceriporiopsis subvermispora (strain B) (White-rot fungus) (Gelatoporia subvermispora) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes>
Polyporales> Gelatoporiaceae> Gelatoporia.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.288 |
Instability index | 49.97 |
Isoelectric point | 6.00 |
Molecular weight | 82860.78 |
Publications | PubMed=22434909
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Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
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GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
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GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP30783
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 137.88| 43| 99| 122| 174| 1
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13- 57 (70.33/35.45) DPSHGQPFTNGFHEPSI...EELLHELPVVQDGQvpLGELVSRVAQAL
126- 171 (67.55/45.43) DAVHGLKYAKDSLDPARlrnHDLLTALDVLTTGS..YRRLPSCIKKAI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 105.38| 34| 159| 536| 571| 3
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536- 571 (54.86/34.59) VTIDART...GRLNLRDTGDLaaAGR.......GSRFALLTQTLNE
688- 731 (50.52/26.61) VTLDGDDtvvGQRRKRGPDDV..GGRtdsvqrfSSRFNLDTKTLRE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 93.18| 28| 340| 257| 287| 4
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257- 287 (46.46/35.26) GLQDFPRRPsgmLKRHILDE.GDARLAFYLPL
600- 628 (46.72/27.17) GLQSYRIRN...FPREELQKlGPARGTLYIQL
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