<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30771

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMDPNDLRPLDDWAHRFFIWHEWIQVYGPLTNENVFDYFATSMFYDKQSNNQVLRMQTMHTGVPLQNEAEELKRFTGVEFAVVHSEPPNFFIIHKRERLSPDEVRPLAVYFITNNRIYQAPDLYTLISNRLLTSLHALQSSLDILRSHRPVYTPRTGFVWPVAEPAVSKDSSKKRGLDEETQSAEDIPGLSGSLQKRQSASSPERQENSLLLLNAMRTTAIHANQSFTLPTAASESSAPEMPAPAPGIRSSATPAPNPARGVTPKRPSNAPTPQEAPPPAKSAPGAGKKKKKRTATLPTLTAT
Length302
PositionHead
OrganismCeriporiopsis subvermispora (strain B) (White-rot fungus) (Gelatoporia subvermispora)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Gelatoporiaceae> Gelatoporia.
Aromaticity0.08
Grand average of hydropathy-0.579
Instability index65.10
Isoelectric point9.22
Molecular weight33603.54
Publications
PubMed=22434909

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364143
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30771
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.58|      32|      33|     235|     266|       1
---------------------------------------------------------------------------
  200-  234 (42.29/17.80)	SS.PERQENSllllNAMRTTAIHANQSFTLPTAASE
  235-  266 (56.64/26.08)	SSAPEMPAPA....PGIRSSATPAPNPARGVTPKRP
  267-  297 (51.65/23.20)	SNAP.TPQEA....PPPAKSAPGAGKKKKKRTATLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.53|      24|      90|      16|      54|       2
---------------------------------------------------------------------------
   28-   51 (43.21/73.39)	PLTNE.NVFDYFATSMFYDKQSNNQ
   63-   87 (37.32/16.49)	PLQNEaEELKRFTGVEFAVVHSEPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.71|      13|      17|      89|     101|       3
---------------------------------------------------------------------------
   89-  101 (23.64/13.54)	FFIIHKRERLSPD
  109-  121 (25.07/14.70)	YFITNNRIYQAPD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30771 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHANQSFTLPTAASESSAPEMPAPAPGIRSSATPAPNPARGVTPKRPSNAPTPQEAPPPAKSAPGAGKKKKKRTATLPTLTAT
2) KDSSKKRGLDEETQSAEDIPGLSGSLQKRQSASSPERQENSLLLLNAMR
220
168
302
216










Molecular Recognition Features






MoRF SequenceStartStop




1) EAPPPAKSAPGAGKKKKKRTATLPTLTAT
274
302