<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30770

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMASKSHPAPQDNTGTSVLSQVPPQISLDSPILASAIDLHEDPLIVYSVYTADPSVDASEQLSIIDSGRRSIVQLNAKRSILGSLLPSAHVTRDQSSLYVFAFGSTAGVSEGQAALEALQLHCLTSQETSFFTPSSLYPCSAACSELPSPCSNCPDIVSADCTTASSSGPPLLRKPLRLPFFQFLQAVRDRLVGDICENSKEKANGRTAVKLKDGFLLSSSPASSEWGAGWEHHARTRPLIYCHLQLHLSHAPPSSARLIIHPVLRPSYYLPLYNMLPLPSGTPMALLPYGVPAFYLSTYSGPSTALTTQFEDSLVGLGAGDWKRPCAISEQRLKPEHARSGCQNSSPTFVIAWLAVQNKQGEEKGIPLIWPARLCITYHPASPSPHARNSLSYIPELSAQLQASPPPPAPAIPSTLSSISSGIALSSDVAGPSVTTIAPEPQTPEHKALPCALGRRIRALTSSPTSDSLRAFRTMSLSSHPYTRNIHKVAGKVSGYVDSIAKERERERERLKRERESREAAAAVRFIPASTSNVVMQTATPSDQPRETTSQSSVQLPGLPSNELPPKRAESPPVPQPVQQMENDAGIEEPSSSPPQDAAESLFSPPEETIDLPPSDDPHVFEDVPMDSARHPYDPPEESSDSQSVHFSADPYIMEPSWMPSSGGFMDNMDYSMSFPMNIDSIGSEPGAGGMTSRYNVEDDFNVFTDDDFSFFDGPATSSRGTALAPLPEVQPVPLSTGFSISSAVTPLNLPPLITGEGIHGSGPGPPSQASPWATTSMAEGFTPHGLDVPFGDDIPPPPDLLPPSPGRTPSSHSAPATPGVHLADAFELSVCKAREPRAGLGIFDPIPFASSHKLADGKYAVGKFAMPSPPDEEDRAEVFLPSSSPARSDGWFSRYTAATDPRFGMVRKLIGVKRKGVVQGPRITRTPSSWQREHEEWASSRLSAPPEDSRSEAESEEEEPWVQEEEETAAPRSSTPPPSYLPLGPTLLQTYFHHRYLLPLSTPLRPPGSAVSNPPASIAATSVPTPVSPAAAVGAASEKSKSLEAAAQMLVREVVENAAWAEAWRANAIASLTAGSLPTEVWQTDVKWVSDLLGTVETTETPMTLRSLYGFSEEESADGNARSDNHVELLEPPMLALGKSEAIVHVLPTALRFWEKLGLGPRAGAKDLVAYMLFEDTTEERQEQLSQWMARVSSAYSAKGYGTHALGIPPKSPTSGLLPVQFDTLRKTLVSLVEQLNPSQWQSTVVFYIAAPASVTSLTSQVLRYLFSAIKRVTKALPDAQLFFHFVPEALASGLLSDPRTTHAGLDAFVDNVYDRILQPVDRAMSRKLFMHSAPTRAYLHAPAMTLARALPSGHPDQSRGYKQSARTSFLLEAHPTSLDVLERHTLLHVGYHTTPDNRWLLAACVDERGEGHEVTAWLLPTESTEDFITSQVWNFVHTFARRASVEWRIVISKLGAMRNLEAQVWISHLDRTVATSSDIPPMHVTLLSVDIDNSWMFVAPDSSDVSFTKRSRSPTTSQSPVRPARVPPNAVFLDVSCSTYAISPAVARTCVPAFGSRQGAQSLVGYDDIPIIPDSEDEEPIMQRTPCLHARLRSALAHVPTGADFASIDMVQLAQLHTISSPKSSRVKTRTISAREQGMEDLRDITSNFHDLAVLARLRWKLPDTGLPFHLAALKVMCMALVGDSVDVNG
Length1692
PositionKinase
OrganismCeriporiopsis subvermispora (strain B) (White-rot fungus) (Gelatoporia subvermispora)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Polyporales> Gelatoporiaceae> Gelatoporia.
Aromaticity0.07
Grand average of hydropathy-0.270
Instability index59.81
Isoelectric point5.54
Molecular weight183132.17
Publications
PubMed=22434909

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30770
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     858.62|     327|     395|     266|     658|       1
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  266-  536 (276.79/161.40)	.....................................................................................................................................................PSyylplynmlplpSGTPMALLPYGV..PAFYLSTYSGPST.ALTTQF..EDSLVGLGAGDW.........KRPCAISE.QRLKPEHARSGCQNSS...PTFVIAWLAvqnkqGEekGIPLIWPArlcityHPASPSPHARNSLS..YIPE.LSAQL..QASPP....PPAPA.IPSTLSS.ISSGIALsSDVAGPSVTTiAPEPQTPehkalpcaLGrriraltssptsdslrAFRTMSL.SSHPYTRNIHKVaGKVSgyVDSIAKERERERERLKRERESREAAAAVRFIPASTSNVVM
  538-  906 (513.82/203.72)	TATPSDQPRETTSQSSVQLPGLPsnELPPKRAESPPvPQP.VQQMENDAGiEEPSSSPP..........QDAAESLF........SPPEETIDLPPSddphvfeDVPMDSARHPYDPP....EESSDSQSVHFSADPYIME....PSWmPS............SGGFMDNMDYSMsfPMNIDSIGSEPGAgGMTSRYnvEDDFNVFTDDDFsffdgpatsSRGTALAPlPEVQPVPLSTGFSISSavtPLNLPPLIT.....GE..GIHGSGPG......PPSQASPWATTSMAegFTPHgLDVPFgdDIPPPpdllPPSPGrTPSSHSApATPGVHL.ADAFELSVCK.AREPRAG........LG................IFDPIPFaSSHKLADGKYAV.GKFA..MPSPPDEEDRAEVFLPSSSPARSDGWFSRYTAATDPRFGM
  925- 1061 (68.01/10.16)	TRTPSSWQREHEEWASSRLSAPP..EDSRSEAESEE.EEPwVQEEEETAA.PRSSTPPPsylplgptllQTYFHHRYllplstplRPPGSAVSNPPA.......SIAATSVPTPVSPAaavgAASEKSKSLEAAAQMLVREvvenAAW..............................................................................................................................................................................................................................................................................................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     196.07|      62|    1373|     130|     195|       3
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  130-  195 (103.25/63.04)	FFTPSS......LYPCSAACSELP.SPCSNCPDIVSAD..CTTASSSgPPLLRkpLRLPFFQFLQAVRDrLVG..DI
 1499- 1571 (92.82/44.59)	FVAPDSsdvsftKRSRSPTTSQSPvRPARVPPNAVFLDvsCSTYAIS.PAVAR..TCVPAFGSRQGAQS.LVGydDI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.22|      19|      30|    1091|    1114|       4
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 1091- 1114 (21.56/29.77)	SDllGTVETTETPMTlrSLyGFSE
 1124- 1142 (35.66/22.13)	SD..NHVELLEPPML..AL.GKSE
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.70|      15|     383|    1273|    1287|       6
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 1273- 1287 (28.27/15.83)	RVTKALPDAQLFFHF
 1659- 1673 (30.43/17.64)	RLRWKLPDTGLPFHL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.88|      18|     397|    1065|    1083|       7
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 1065- 1083 (29.45/23.56)	WRAnAIASLTA.GSLPTEVW
 1449- 1467 (29.43/17.97)	WRI.VISKLGAmRNLEAQVW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.30|      14|    1135|     450|     465|      10
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  450-  465 (22.67/12.82)	PCAlgRRIR.ALTSSPT
 1588- 1603 (18.64/ 9.04)	PCL.hARLRsALAHVPT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30770 with Med13 domain of Kingdom Fungi
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