<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30765

Description Mediator of RNA polymerase II transcription subunit 19 (Fragment)
SequenceMSSTDDERSPKRQRRSFSPPSPIPADDTKAAFVQPPQTPPASVHMSPSWQSSLSQQVGGGSFPTPPSTAGFQSQQRVGGSESGEPTPVPEEEQVREAYGVADTPDKQDELQREPHLGKRKREADDDDEENTAGAKHRRTDHERQDDTNGGDGAESLQPPPPPPPRLFKLSAKPIAPTRPLPSENILSLYSLTVVQASVARKDAAGNKINKLRKSYENKVKALGLMGRTKPQEGKNELLGLLDPGWDMDIGQGRTMFEAHAAECLLGDRASEQDLTSKLNVALRLAPGHMPRTEHEKWKNLLALDEPRVGTPVQAATKPVGLQMNPALAKTAPGQPGPQFAVPRSPLAVNGVARPERSGKKRRYDESSYAGYHEGYEDDGYSTGGGDETGARRGSASKRLR
Length400
PositionHead
OrganismBaudoinia panamericana (strain UAMH 10762) (Angels' share fungus) (Baudoinia compniacensis (strain UAMH 10762))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Baudoinia.
Aromaticity0.04
Grand average of hydropathy-0.980
Instability index68.49
Isoelectric point7.12
Molecular weight43346.58
Publications
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30765
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.61|      15|      18|      47|      61|       1
---------------------------------------------------------------------------
   47-   61 (29.85/19.33)	PSWQSSLSQQVGGGS
   66-   80 (28.76/18.35)	PSTAGFQSQQRVGGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     330.08|      92|     150|     113|     215|       2
---------------------------------------------------------------------------
    5-   46 (33.42/ 6.47)	.............DDERS......PKR.QRRSFSPPspipaDDTK....AAFVQPP.QTPPASVHMS.........................................
  113-  207 (156.84/74.69)	EPHLGKRKREADDDDEENTA...GAKH.RRTDHERQ.....DDTNGGDGAESLQPPPPPPPRLFKLSAKP....IAPTRPLPSENIlSLYSLTVvqASVARKDAAGNK
  262-  360 (139.82/51.71)	ECLLGDRASEQDLTSKLNVAlrlAPGHmPRTEHEKW.....KNLLALDE.PRVGTPVQAATKPVGLQMNPalakTAPGQPGPQFAV.PRSPLAV..NGVARPERSGKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30765 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EHEKWKNLLALDEPRVGTPVQAATKPVGLQMNPALAKTAPGQPGPQFAVPRSPLAVNGVARPERSGKKRRYDESSYAGYHEGYEDDGYSTGGGDETGARRGSASKRLR
2) MSSTDDERSPKRQRRSFSPPSPIPADDTKAAFVQPPQTPPASVHMSPSWQSSLSQQVGGGSFPTPPSTAGFQSQQRVGGSESGEPTPVPEEEQVREAYGVADTPDKQDELQREPHLGKRKREADDDDEENTAGAKHRRTDHERQDDTNGGDGAESLQPPPPPPPRLFKLSAKPIAPTRPLPSE
293
1
400
183










Molecular Recognition Features






MoRF SequenceStartStop




1) DTKAAFV
2) FKLSAKPIAP
3) GKKRRYDE
4) RRSFS
5) SYAGYHEGYEDDGYSTG
27
167
358
14
367
33
176
365
18
383