<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30764

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFFKSCKTNVQRIDELWKTTFTKYNWAGEQQNLEELVLELHEQGVLCAAVSLELWLFGLPGAQRTNSARNEGLQFHEFGTLEDSPGLCAADGSSVRGVLLAAIEVAIAARLARTQLTLRVGPWTWLLRHRSDAEFAEGCCLVLRIETRLTDLGSLYITTTTRPTRLATLSGRDPVNAALLIAPGGQIVSLTSAASASATLLDGARWHEIVTAGLRRDGLSVASGERWVRVQTAPLEDTFTWPESLCFVMLNSPSQAPELTPHDWRHYFDRFEEDDGFKHPLAVAEDWFNAAEDQGVPGVDNPPQTTTGVEGAAALNENLIAENALVTSPPFNQRTADQQAAMSGIYPTPPDGFLPGQASQQPVSDPVTANISHGDMEAVATDLQMTSVEQQHERRQQTSSTDLSSVHRHASDDLFGDMGGEMDFGGDEVGDADFDFFNEDGNDADDRQAGSETHAEGVPVEHMREDTSPIAANPNFPMDAESYALNVEQPSTDTEASAAGSGATPGGNVEAHSFTAEPVQPHAGRDALVGRPLSPFGIKERLLPPPVPASMQFNTPLQRSGLRRSGIFDPMPFKESLELGGPFASQYGRVASGRDYVIKQRSQFDITLPPRRKRSDLNLRAEAATDSSDEYSDSDSENDLYESASSVSDENLPPKAPWSTKKRKREDYEAVLSDGTVTAGLDWTLRQAGPAAASGEVMRSMLDRLVGARAGADVWLSSSRMDSTVPDDMLPPIQDVLQLTKMDLIYTAQLVSEQAVSCSPSIVRSLDILPTDHKRELAVQSAVREVTEETIRDLVTGIAPCEIAEIALIREPLNKNMPAASNPRPGQPRPPQRANTTELGPDIAAILPPYVRVQRGNDAYEMLPPALDFWETLSLAPVNGQKDVRAYCIFPLNEDLQRLAEGFIADLGTAYEGCKLGTHAHIRNVSEENELDDYEDGLAPVELTDDDTLVGAIKAYAAVSVNLGKFLASVASLETDRTIVVYLINPFQHPRAARYICACFWLLCKAYRDNVPKNQRSQQQSDVAFQLLPIELIACPDGMVMLDAKQLANIAREVYDRCPPTTNSGAEAKAALPNYAAPFVELACPPPKRIGFQLVAEPPGDLLHEGSALHLAYAVSADGKWMTVAWTDSSGRNQSNSSFCLCGRTFANVLVDIWERTRGIMAAREATWRVFVVTDGPIDDSISRCWRQTVQSPRKQAFSVTLLSAKLDMGLQLTPHFLTTGDTTGTVAATTTGFLTPGSTPQAALTTVSPEAATHAAPPTPAPSDAAVASAEPDPDAHFVDLADETWAVVFSQPNFLPSSPVSTTPTPSVNGLAQGALFKRGEAGLDGVGVPGDHLPSLGVTLLWTVQVRPSGSVDEGGAKQAEMALREMLKLYRHLSVLTRARGLGDDGVGGSGDGNGNADACVPFHLVAARRGAAALDGLYG
Length1425
PositionKinase
OrganismBaudoinia panamericana (strain UAMH 10762) (Angels' share fungus) (Baudoinia compniacensis (strain UAMH 10762))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Baudoinia.
Aromaticity0.07
Grand average of hydropathy-0.276
Instability index45.70
Isoelectric point4.73
Molecular weight153714.19
Publications
PubMed=23236275

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30764
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.48|      10|      15|    1215|    1224|       1
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 1215- 1224 (20.65/12.30)	TPHFLTTGDT
 1232- 1241 (19.83/11.48)	TTGFLTPGST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.06|      12|      20|     204|     220|       2
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  204-  215 (23.43/18.89)	GARWHEIVTAGL
  225-  236 (23.63/ 6.79)	GERWVRVQTAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.10|      16|      20|     258|     277|       4
---------------------------------------------------------------------------
  258-  277 (23.71/28.80)	PELTPHDWrhyFDRfEEDDG
  281-  296 (30.40/18.24)	PLAVAEDW...FNA.AEDQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.70|      17|      19|     690|     707|       6
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  687-  704 (24.54/18.07)	RQAGpAAASGEVM..RSMLD
  705-  723 (26.16/13.58)	RLVG.ARAGADVWlsSSRMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.52|      23|      23|    1044|    1066|       7
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 1044- 1066 (42.48/22.72)	DAK.QLANIAREVYD.RCPPTTNSG
 1068- 1092 (35.03/17.49)	EAKaALPNYAAPFVElACPPPKRIG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.73|      11|      19|     414|     424|       8
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  414-  424 (21.67/12.82)	DLFGDMGGEMD
  436-  446 (21.07/12.25)	DFFNEDGNDAD
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.01|      29|     111|     789|     817|      10
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  789-  817 (48.75/33.63)	EETIRDLVTGIAPCEIAEIALIREPLNKN
  902-  930 (49.26/34.07)	EGFIADLGTAYEGCKLGTHAHIRNVSEEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.27|      29|      49|     450|     481|      11
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  450-  481 (44.56/37.87)	AGSEThAEGVPVEHMREDTSPIaaNPNFPMDA
  500-  528 (52.71/32.75)	AGSGA.TPGGNVEAHSFTAEPV..QPHAGRDA
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.86|      15|     114|     535|     551|      13
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  535-  549 (28.53/18.62)	SPF...GIKERLLPPPVP
  556-  573 (23.33/ 7.39)	TPLqrsGLRRSGIFDPMP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.93|       9|      17|     382|     392|      16
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  382-  392 (10.96/12.22)	TDLqmTSVEQQ
  402-  410 (16.98/ 9.48)	TDL..SSVHRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.01|      34|      39|      16|      50|      17
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   16-   50 (56.84/37.29)	ELWKTTFTKYNWAGEQQNlEELVLE....LHEQGVLCAA
   54-   91 (56.17/32.60)	ELWLFGLPGAQRTNSARN.EGLQFHefgtLEDSPGLCAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.87|      24|      41|     588|     611|      18
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  588-  611 (43.16/25.25)	YGRVASGRDYVIKQRSQFDITLPP
  632-  655 (41.72/24.18)	YSDSDSENDLYESASSVSDENLPP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.33|      14|      26|     852|     865|      19
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  852-  865 (25.59/16.40)	VRVQRGNDAYEMLP
  879-  892 (26.74/17.47)	VNGQKDVRAYCIFP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.02|      20|     957|     348|     367|      21
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  348-  367 (40.97/24.37)	PTPP.DG......FLPGQASQQPVSDP
 1307- 1333 (28.05/13.98)	PTPSvNGlaqgalFKRGEAGLDGVGVP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30764 with Med13 domain of Kingdom Fungi
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