<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30758

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMALADADLPPQLDQSWRTSEHNKSLGKLMDRLAQQCYMDLNSTLTQMSELGAPGDGAPQVNGALPHDQTDTSELSLRKKRMFMEFAHDQRDRFTKTLVLSDYSRNEEDMAKLIDIKIWQDKQRWAYAHTLEAIGHTKRRMLDFKVPAPNIESAMELLATGKASWVPDLGYIPPKRLSAKQLLSTLRDMNVALATRLNLHDELPPFMNQYTIANGRATFSVSGEFEVDLSVADEDPASPWYFIDVRFLFSPSSDTLNDQLRAHLEPRANEALGRACLQGCYGFLHNFVLTHKINVLRSQAQDLIRSKWFDCIKIESLRRSLIIQYWAGMPGPKSWFEIGISSGTRKSGSNKKSTPTLCVRWFRKGQEVRDEQLQFDWQNLNLEAALMEVISKHCFGKLAMARDGLHTIKDRTAPGSSALSAVMPNPDTTVHDRALSVNIPSLRTPLRVSLEPISGQFSLAPPSRATASAERVLNREVSVDVPRLLATVVCGMAQDLYQRQSELVGWQPIRNVAVPKEKFGTDLWKHSVFSLPNCGQQWGLGITFGLGGETWWVMELKSVKPQDNPDRVSTEVLQAHKLDVTDIFGVPTEISRASLVRVERRAGATISRLVLSRQLDELKVPYDVKKASALTDVKHRRGPDSNEVSFVQFSALMRDTTDKDWKPWARDAVRISYHGRDGSVHAASDGDERALVRHDLRLSIGKDRLPHLRQHFKPTSGADTVMNDNGGLALRLQTPFGEPLLGQVKTRLRSVERLDGYINVLQKLHYTCTFVSLAKLCFTYSKSPELDAQLSFANDGSLPVRLKLEPADSNPHLRIMIMLERCLNSRITNSFIFFASTLSLTLPLLQAFDRLETAHLARRTATAHARGIVWYEVAYRAPLPVCKFSIKSDTKRRNGKAKVFWHLTQHAPRSESTILPEGFEAALKGLWREKGQGWFGVGNGAIADAAGIAVVVMKLDEVMRRFESIADPVEKSGGETAPIEQSAPGKTATNASQPAAQSTASKTAVKVKEEPDVIMLD
Length1016
PositionTail
OrganismBaudoinia panamericana (strain UAMH 10762) (Angels' share fungus) (Baudoinia compniacensis (strain UAMH 10762))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Baudoinia.
Aromaticity0.07
Grand average of hydropathy-0.348
Instability index41.43
Isoelectric point8.97
Molecular weight113569.44
Publications
PubMed=23236275

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30758
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.07|      23|      25|     657|     680|       1
---------------------------------------------------------------------------
  657-  680 (40.27/30.62)	DKDWKPWARDAVRISYhGRDGSVH
  684-  706 (40.80/25.47)	DGDERALVRHDLRLSI.GKDRLPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.28|      11|      25|     307|     318|       2
---------------------------------------------------------------------------
  307-  318 (17.69/17.29)	WFDcIKIESLRR
  334-  344 (22.59/14.67)	WFE.IGISSGTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.25|      30|     180|     196|     265|       3
---------------------------------------------------------------------------
  202-  234 (45.58/85.34)	LPPFMNQYTIanGrATFSVSGE..FEVDL.SVADED
  530-  562 (50.67/12.07)	LPNCGQQWGL..G.ITFGLGGEtwWVMELkSVKPQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.57|      18|      32|     585|     602|       5
---------------------------------------------------------------------------
  585-  602 (30.54/23.21)	VPTEISRAS.LVRVERRAG
  619-  637 (28.03/20.63)	VPYDVKKASaLTDVKHRRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     170.34|      53|     357|      11|      69|       7
---------------------------------------------------------------------------
   11-   69 (85.47/65.01)	QLDQSWrtseHNKSL.GKLMDRLAQQCYMDL...NSTLTQMSELGAPGDGApqVNGALPHDQT
  371-  427 (84.87/50.01)	QLQFDW....QNLNLeAALMEVISKHCFGKLamaRDGLHTIKDRTAPGSSA..LSAVMPNPDT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30758 with Med14 domain of Kingdom Fungi
Unable to open file!