<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30754

Description Uncharacterized protein (Fragment)
SequenceMDKRTTLSTLTRPTPPQRAASGSSVYFAKPGVRPSLPSRLSSVRSASQPSHVVDLTAEGLQASRRGSAASFGLNGSVCTSPDIIQVDDEEDGQPPAKRARLTGDGLRAGGDGEESEHGLAYNVVEGEELPAPPKQTTPNAQGALARRRRRVGESTARKATGVVPPPVATKLPPPKNVADFCVWTGNHPEDTLNDAVVKAGYSDTKLSSTNESNSAKPSIWQNLTSKNNTGLQMLSYLFTQVLDKKQALGKCTAPSTFKPPPRVTVTDTKREAWLRDLANPDVPLRKQSRTIPHGIRGKLLLDQCLSKDIPLQRAVWLAKCVGANELRAFRRKGVTGAIAASGESKWVREWTVSVEQFFEGVIASCGEQEWQGRMNYAVKLVTALYAEGLLEVDHYLDWIVSNFAEATIGRLPIWIVLVLIFWKHVIRFVRRGRTLAEATLAHIHGLHEVPRTSNEALRLRLQKLIAVLAVTSRGCLVIPSTWQKYKHLLKPSGPANAESTMKSIVEDIARRNERLVVSSTETLARIRGPLVKLYDILDSVGLDSDIDELTKQCSAQIPDTSHLLAALLDWASTPYRYGDARVYLSATIIQILRRQGHDTDAAVLAWLGDADRRTSAQLELVYRVIGELVRFNAFAVGRYLQFLISTG
Length647
PositionKinase
OrganismBaudoinia panamericana (strain UAMH 10762) (Angels' share fungus) (Baudoinia compniacensis (strain UAMH 10762))
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Teratosphaeriaceae> Baudoinia.
Aromaticity0.06
Grand average of hydropathy-0.265
Instability index38.81
Isoelectric point9.45
Molecular weight71031.23
Publications
PubMed=23236275

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30754
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.05|      33|      36|     559|     594|       1
---------------------------------------------------------------------------
  559-  594 (52.48/41.53)	DTShllAALLDWASTPYRYGDARVYLSATIIQILRR
  598-  630 (55.56/35.61)	DTD...AAVLAWLGDADRRTSAQLELVYRVIGELVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.38|      24|      36|      64|      98|       2
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   64-   95 (36.25/48.47)	RRGSAASFGLNGSVctspdiiqVDDEEDGQPP
  110-  133 (44.13/25.97)	GDGEESEHGLAYNV........VEGEELPAPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.23|      23|     164|      39|      61|       3
---------------------------------------------------------------------------
   39-   61 (39.34/25.93)	RLSSV..RSASQPSHVVDLTAE...GLQ
  205-  232 (30.90/18.82)	KLSSTneSNSAKPSIWQNLTSKnntGLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.87|      21|      42|     269|     290|       4
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  270-  290 (37.40/24.00)	REAWLRDL..ANPDVPLRKQSRT
  313-  335 (29.47/13.09)	RAVWLAKCvgANELRAFRRKGVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.97|      15|      36|     476|     494|       5
---------------------------------------------------------------------------
  476-  494 (22.29/27.75)	LVIPSTwqkyKHLLKPSGP
  515-  529 (25.68/16.43)	LVVSST....ETLARIRGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.49|      22|      35|     349|     381|       6
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  349-  381 (29.23/43.16)	EWTVSveQFFEGVIascgeqewqGRMNYAVKLV
  397-  418 (41.26/25.34)	DWIVS..NFAEATI.........GRLPIWIVLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.46|      22|      85|     157|     179|       7
---------------------------------------------------------------------------
  157-  179 (36.90/25.08)	RKATGVVPPPVATKlPPPK.NVAD
  245-  267 (37.56/21.09)	KQALGKCTAPSTFK.PPPRvTVTD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30754 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LNDAVVKAGYSDTKLSSTNESNSAKPSIWQNLT
2) MDKRTTLSTLTRPTPPQRAASGSSVYFAKPGVRPSLPSRLSSVRSASQPSHVVDLTAEGLQASRRGSAASFGLN
3) VCTSPDIIQVDDEEDGQPPAKRARLTGDGLRAGGDGEESEHGLAYNVVEGEELPAPPKQTTPNAQGALARRRRRVGESTARKATGVVPPPVATKL
192
1
77
224
74
171










Molecular Recognition Features






MoRF SequenceStartStop




1) SSVYFAKPGVRP
23
34