<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30738

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMTSDKMPLMLDHSMPMDLNNVDDLFGDGVSLQLSMRSQGKQLQQRLDELRNRGCCQAVTWSKLGTIASLTPDGQNIELRFPRCHPEDGTWDLSEATICDLVKGSPAIPLVHLEWSPTHIQELAVIDAVGRVTIVPFGTSLNHLFPPRKWEADTVDHIHGISGCYWLPVPPPPQQKSLNVMYGPANKQGNGYQYESSFYHALGPCHPNPNKSAFFCIGMNGTLKMYWAQNNGRIEETTMELESVSATDELVTHASFSSDSKCLLAALVTSSNQLKLLKIEIQWAGPGSSSEKNSMPQNARLNPALVETHLASVNSLCAGRHEAMQDASDVEVSFVQVLPAIMDNMGSRAATPLVLTVRSRAASDSGFQLAQSILDRWEVVETRHSLDPAFEEMGRSNSVPSEPPSSIRLRRLDPVVIHKVVIGVQVIYFGKTLLLTMSDGSMEYRDRFTFEEAYANQDLTDIMSLRQAGWSFSDTGLCLHAAVSPSCCSMAQIGEDGKVRWNKLQYALEDIGNSVQDPHYLATIASISIATASAMCHQSSYDDLLAVLQPITSKKKFVPDWVGEIIRVLKIPVDYSDETHHDALMRNQPLQFCLGIMNSLGFKGESKKRSFQSKFSMINLNMRNVVLLITLSSNSHPSIRDKSNPLDDHDVVDALAGCAQWTVDLLSWLMDSLLELQNDVEFRQRCCQQRFGEMNMFLHSRNDVSLHLLLSSSSRSFLSAICRRVELLHVMSNDAMAFYKTHASGNVPSGDKPLNPQLQRAYYKIQKITSTSIIKVAEFEKLLNVLSQDIKQAYALYLPLLVKKQPSMSGAPAKQLDLAVKNTRSQYEMSMLLSGPPPPVFLPVIKKFFGQDLPAFRSKHLDPARLFFADFDLLAVQDDPVSLAARASNPVYVDTFKKRNNASVLVGAIGGSFPGGS
Length916
PositionTail
OrganismClaviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Claviceps.
Aromaticity0.07
Grand average of hydropathy-0.179
Instability index50.29
Isoelectric point6.18
Molecular weight101512.95
Publications
PubMed=23468653

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30738
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     126.56|      43|      54|     789|     840|       1
---------------------------------------------------------------------------
  789-  840 (60.19/58.35)	IKQAYALYLPLLVKKQPSmsgaPAK....QLDL.AVKNTrsqyEMSmLLSGPPPPVF
  844-  891 (66.37/39.22)	IKKFFGQDLPAFRSKHLD....PARlffaDFDLlAVQDD....PVS.LAARASNPVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.77|      34|      54|     226|     261|       2
---------------------------------------------------------------------------
  226-  261 (50.21/43.10)	WAQNNGRIEETTMElESVSATDELV.THASfSSDSKC
  282-  316 (56.56/38.00)	WAGPGSSSEKNSMP.QNARLNPALVeTHLA.SVNSLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.91|      52|      55|      94|     146|       4
---------------------------------------------------------------------------
   71-  125 (49.45/30.37)	.........PDGQNIELRFPrchPedgtwdlsEATICDLVKGSPAIPLVHLEwSPTHIQELAVI
  126-  180 (89.82/51.25)	DAVGRVTIVPFGTSLNHLFP...P.....rkwEADTVDHIHGISGCYWLPVP.PPPQQKSLNVM
  183-  215 (24.64/ 8.73)	PANKQGNGYQYESSFYHALG...P.chpnpnkSAFFC...........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.65|      53|     630|       1|      56|       5
---------------------------------------------------------------------------
    1-   56 (88.97/67.71)	MTSDKMPLMLDHSMPMDLNNVDDLFGD....GVSLQLSMRSQGKQLQQrlD.ELRNRgCCQ
  630-  687 (85.68/54.52)	LSSNSHPSIRDKSNPLDDHDVVDALAGcaqwTVDLLSWLMDSLLELQN..DvEFRQR.CCQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.47|      56|     119|     335|     399|       6
---------------------------------------------------------------------------
  335-  399 (88.81/77.82)	QVLPAIMD..NMG.SRAATPLVLTVrsrAASDSGFQLAQSILD...RWEvvetrhSLDPAFEEMGRSNSVP
  456-  517 (90.66/58.90)	QDLTDIMSlrQAGwSFSDTGLCLHA...AVSPSCCSMAQIGEDgkvRWN......KLQYALEDIGNSVQDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30738 with Med16 domain of Kingdom Fungi
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