<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30737

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEPSGSNDRRTDHNRDITTNGVNGGEIVESRRAGAVKGGVAAGQTEASDDTSAGAQESLRRHDPDINEATAETQRNRMNDLPDEIVHITQGFVPLSLLFTRLAQVSHNALQDKIVELAKMPLPVTGNNGVSSSYSSSGPDDTSPESLRKKGALLQFAQEWHGKWLKALVIAEWSRQSHQVSKLIDLKFHIDQQAVTYEAAVENIIHVKRDLAFARVPSPDLKTALQVLGTGSAPWMPDLHYIQPPALTPEEQLKWTSELNTLLSLRLNLYDYDKIPPQFRDYEIRSGRVTFKVDGEFEVDLTIADEDFEKQFWYIEFRFAFKPAPSRLSDFLRSYVEGGVNDALGKEGLGACYKFLHEFVLTIKIQELRRQALQLSRTSWTGTLKVEPLNRALAIQYWTSRPATNGLKSWVLIAVNGNRMLNGKYNVNSSSQLVAKWYRDGKAVQDHLTGFDVHELSVQSLLTNVIAQHIEHILGDVHSRLLTAARYKRQEAGMVFRTCKNDPVSSMLTIQVGCSDKISLLLEPKTGVFAIKPQSKFSMQPEHQLNNGSCSPEDGVNCLEQVRCAIMEDEVHRRGPLMGWNVRKAAMTAEELRSLTRIRDWSRVIWLQKEGWDASWCVVIVLSLGGDEWWLIESNRHRKNDKQMPQVRTKIPLNGYPELSYAFWNDLAFFTTGLITRSIDLRELHRQKIKNRSNSKSSSSASPLVLLPSIEIALSAFLPATTFTRDGFESDASASEDGGGHENLDHLSLIQHATGNTVSRVNKAWADDIVNISFKGIKSLAPVDVKNEDASQDTQLICISEAVIRTRISARSALLSNLADGDVSYNSRRGQFLLRIERAVGMPMLDTLKSRIMAIDRFVKFLEAMDSAGGFITTDTVTLRRIAFYYSEFTSRRQQQTEQNHGQGQTRGEESRTDKRWRVVLDLSKQDIEIEIEKGNPHLRVLDLMRQLVNCDDGISRLMSWLPTSLPALQAIDEIASLWIPFIVAGRGYFDFSMKTAAWMNLTYTIGTVQEPQSLKIVSVDVKVKSRRGEAWWHVWRSDTDANSQDDISRALKRVWDSKGEGWIGLATGAAGRPQKGVGAMLLAVDEAVRGSVTDAPAENNEVVVLD
Length1107
PositionTail
OrganismClaviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Claviceps.
Aromaticity0.08
Grand average of hydropathy-0.364
Instability index48.77
Isoelectric point6.45
Molecular weight124094.07
Publications
PubMed=23468653

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP30737
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.09|      42|     261|      79|     210|       3
---------------------------------------------------------------------------
   80-  126 (59.86/132.10)	DLPDEIVHITQGfvpLSLLFTRLaQVSHNALQ..DKIVELaKMPLPVTG
  943-  986 (73.23/11.36)	DLMRQLVNCDDG...ISRLMSWL.PTSLPALQaiDEIASL.WIPFIVAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.27|      36|     450|     573|     612|       7
---------------------------------------------------------------------------
  573-  612 (55.41/45.31)	RRGPLMgWNVRKAAMTAEELRSLTRIrdWSRViWLQK.EGW
 1027- 1063 (66.85/38.52)	RRGEAW.WHVWRSDTDANSQDDISRA..LKRV.WDSKgEGW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30737 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MEPSGSNDRRTDHNRDITTNGVNGGEIVESRRAGAVKGGVAAGQTEASDDTSAGAQESLRRHDPDINEATAETQRNRMNDLPD
1
83










Molecular Recognition Features






MoRF SequenceStartStop




NANANA