<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30736
Description |
Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MTTPNDPPLDEIQWRSPQTIASMGGLHSNTVLFYFAESPFFERTSNNAIIMSQAMNNMSMYHYIQTREAFEGRLRTMSGLEFMVGEEPAETGPGMGTGVWVIRKQTRRKQQYQEEDEITVHASFFVVGENIYMAPTLADILASRIMTISSAIAKALPAADSIRKWRPSTGHVYELPTTANQSRPTKAQESKAATPSLPPNGQAATNSTKIEQKTDEAQLERSAEEALLMHMRYGGEYIDENPITGRPGEFHLSTTGRKPVPLPLKKTPETSGIGAMNGPAMGGAKVEGGKKEGRGPKTPKTPKTPKSATTPKLKRKKAKMSAANTPMAS |
Length | 329 |
Position | Head |
Organism | Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Clavicipitaceae> Claviceps.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.633 |
Instability index | 52.57 |
Isoelectric point | 9.46 |
Molecular weight | 35971.56 |
Publications | PubMed=23468653
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP30736
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 90.46| 26| 30| 243| 270| 1
---------------------------------------------------------------------------
243- 270 (43.02/26.96) ITGRPGEFHLSTTGRKPVPLPlkKTPET
276- 301 (47.44/24.65) MNGPAMGGAKVEGGKKEGRGP..KTPKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.17| 17| 128| 176| 195| 2
---------------------------------------------------------------------------
176- 193 (23.74/17.28) PTTANQsRPTKAQESKAA
207- 223 (26.43/ 8.97) STKIEQ.KTDEAQLERSA
---------------------------------------------------------------------------
|