<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP30735

Description Related to SRB8-DNA-directed RNA polymerase II holoenzyme and Srb10 CDK subcomplex subunit
SequenceMTSRNPMSSQARQPQRGPGPMMQLQRPSNLAHRTASSSQQQCHSTPPPKRDLVSAANASMEPADAWSNRHMSIPRRQGSKLRLELSNDFVADEASPATEAPPTLSNPRIVLASSPEAMDIDKMSPTLSGSSRHGSIENNPMPMPRRRLPASSQTVPSTRPIMPATTTPARKDARPKPYTVEIPAVAPRLASSDRKDIVKRDPFSKGLFSGHADFFPWSGAHHEDEWSTEAIQKGTWDRGSRDEVSPARLVIFPPLKQKCGLNALSTIFMGVLSQRRHRGQITSPWTFKPPPRVTLTDTKRESWVRDLANPAISLRRLSRTIPHGIRGRVLLDQCLNKDIPTERALWLAKVVGANDIRAFNRKGSGAPSVSGVDSKWLRDWTVCVEQFIEAVASAFGEPDWKSKVNYAIRLATSLYSEQLLDRDHYLEWIVSSLETSPQSRIPMWILIAQIHWPHLLQLRKCGRRLVSSLLHHLQAIEKDPDRDILIQLSDRLSTLAISLIKENPESFICPPAWQRFGETLRLHLPADDIVAQESYDNIKLRNERLSVTSTSSPTGGLPYLVLLLDSTLQGKRIHDLSSRCWESVEDKMEVVRGTMEWATSLHRPGAAKIYVAVGLIKAWDILQVNTTTVILDVLGCIGPDDNGRKKGMTHLVSELVQSGHFCVSQYMKWLIGRGGLHNAGEIDPVDGPCASRLLVDLPVYCLLREHAYERGNLLRRAGNYSVVDEENDTANAIECVDNSLGLAMYLGNSDISRKPMSRKKLLRRVMNSSGAVQSAIGAHLCDAVTTRLPCDPRFVMTLDTFIPIRTMMETIEDFTKLADIVKSCSAGPDTEVLAACVDTINANLDIFMAMGSAETLFEVFAERLVSISRDQGTPIRALLAALSALAPRLPGRDDVAKQLALDLAQNDRSNALDACSPVSDSMAAQAQTASGEVSEQIDKLLASGNVIDHPTMNRLFRYIAPKLEAGWVKLDDNRRIFASLLSKLRMLDAPHFDRLMADWISHIRTLKKRPPLPALFPLLVSLGCLSVATILHTANVSSVVMAGGATESTMPKSATYLQEVLQMTTMKIVKMPTLDAEEAYRFRIQQQSAKFDHAKALVLLIRNAIIEYAAMRHAPALAEDSWTPPLDSPECYDCLLETMRWVIVADAAMVARVLNVNALPSAARKVAHEMVTRLLLPWLPREASGDQNLSFEEVLRLADDLTKPFCQLKLNFDLSNKQPGAIKHDADGRGDADGPPRFDAFTKAMDKAIQSQNIMWTSMLPCLSEDITQGFSREAHTRFLDLIPTSKSSDTVMTDTSDLSQIRLAENLLGVIEAINSKHSPSSPPPFRQSSPLTDSLIDKLTNLWQVIACPGEDGVALTKRRQVLENWLPILLRFITVNSICESSNSSINSNSSSSISNNTTTVPNSGGNNTTTTSIGSSSTAAAAAAATPTSGPSTTTKPLSTATQEAKARIIIILCGLLLEMDILPHEPVPTTRTLSSQVFDTAILLADSLPDDLRTLCAKALLFLPGSPPSASTTSDWRMYYLLSTLPPTPMENLRLAHREKPSVPHTAAARGMGALYGIGPGSSERLGPFVMRRWETISEPTPTVGENDMSLSMGLFQAIRI
Length1606
PositionKinase
OrganismClaviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Clavicipitaceae> Claviceps.
Aromaticity0.05
Grand average of hydropathy-0.215
Instability index49.54
Isoelectric point8.03
Molecular weight176661.46
Publications
PubMed=23468653

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
DNA-directed 5'-3' RNA polymerase activity	GO:0003899	IEA:UniProtKB-KW
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP30735
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.88|      31|      35|    1377|    1411|       1
---------------------------------------------------------------------------
 1377- 1407 (52.23/37.01)	TVNSICESSNSSINSNSSSSISNNTTTVPNS
 1413- 1443 (50.65/25.49)	TTTSIGSSSTAAAAAAATPTSGPSTTTKPLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.47|      34|      36|     385|     420|       2
---------------------------------------------------------------------------
  385-  420 (47.11/33.71)	EQFIEAVASAFgEPDWKSKVNYAIrLATSLYSEQLL
  423-  456 (63.36/35.99)	DHYLEWIVSSL.ETSPQSRIPMWI.LIAQIHWPHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.32|      30|      36|     655|     686|       3
---------------------------------------------------------------------------
  655-  686 (52.95/44.05)	LVQSGHFCVSQYMKWliGRGG.LHNAGEIDPVD
  694-  724 (49.37/34.17)	LVDLPVYCLLREHAY..ERGNlLRRAGNYSVVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.37|      29|      35|      99|     127|       4
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   99-  127 (48.31/26.49)	EAPPTLSNPRIVLASSPEAMDIDKMSPTL
  137-  160 (37.64/18.81)	ENNP.MPMPRRRLPASSQT..VPSTRP..
  163-  189 (39.42/20.09)	..PATTTPARKDARPKPYTVEIPAVAPRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.13|      13|      35|    1233|    1246|       6
---------------------------------------------------------------------------
 1233- 1246 (20.91/16.33)	DGPPRfDAFTKAMD
 1269- 1281 (24.22/13.38)	QGFSR.EAHTRFLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.88|      45|     187|    1283|    1331|       7
---------------------------------------------------------------------------
 1283- 1331 (71.93/52.33)	IPTSKSSDTVMTDTSdlsqIRLAENLLGVIEAINSK...HSPSSPPPFRQSS
 1472- 1519 (71.95/43.31)	VPTTRTLSSQVFDTA....ILLADSLPDDLRTLCAKallFLPGSPPSASTTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.72|      20|     215|     272|     300|       9
---------------------------------------------------------------------------
  272-  295 (28.99/36.19)	LSQRRHRGQItsPWTFKppPRVTL
  312-  331 (34.72/14.47)	ISLRRLSRTI..PHGIR..GRVLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.11|      30|     219|     787|     831|      11
---------------------------------------------------------------------------
  779-  812 (51.08/49.13)	HLCDAV........TTRL.PCDPRFVMTLDTFIPirtmMETIE
  816-  854 (39.03/38.66)	KLADIVkscsagpdTEVLaACVDTINANLDIFMA....MGSAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.62|      35|     188|     726|     773|      12
---------------------------------------------------------------------------
  726-  763 (53.10/53.32)	ENDTANAIE.C..VDNSLGLA...............MYLGNSdISRKPMSRkkLLR
  905-  957 (44.52/15.94)	QNDRSNALDaCspVSDSMAAQaqtasgevseqidklLASGNV.IDHPTMNR..LFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.74|      34|      40|    1530|    1563|      14
---------------------------------------------------------------------------
 1530- 1563 (60.13/33.78)	LPPTPMENLRLAHREKPSVPHTAAARGMGALYGI
 1571- 1604 (60.61/34.11)	LGPFVMRRWETISEPTPTVGENDMSLSMGLFQAI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP30735 with Med12 domain of Kingdom Fungi
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